Exploring Aquaporins in Human Studies: Mechanisms and Therapeutic Potential in Critical Illness DOI Creative Commons
Charikleia S. Vrettou, Vasileios Issaris, Stelios Kokkoris

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1688 - 1688

Published: Dec. 20, 2024

Aquaporins (AQPs) are membrane proteins facilitating water and other small solutes to be transported across cell membranes. They crucial in maintaining cellular homeostasis by regulating permeability various tissues. Moreover, they regulate migration, signaling pathways, inflammation, tumor growth, metastasis. In critically ill patients, such as trauma, sepsis, patients with acute respiratory distress syndrome (ARDS), which frequently encountered intensive care units (ICUs), transport regulation is for homeostasis, dysregulation can lead edema or dehydration, the latter also implicating hemodynamic compromise. Indeed, AQPs involved fluid organs, including lungs, kidneys, brain, where their dysfunction exacerbate conditions like ARDS, kidney injury (AKI), cerebral edema. this review, we discuss implication of clinical entities ICUs, systemic inflammation AKI, brain due different types primary from a perspective. Current possible future therapeutic implications considered.

Language: Английский

Insights into the Role of the Glymphatic System in the Pathogenesis of Post-hemorrhagic Hydrocephalus DOI

A Massoud,

Dillon A. Noltensmeyer, Jenifer Juranek

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

Citations

2
Role of aquaporins in brain water transport and edema DOI Creative Commons
Yuyuan Li, Yanfang Wang, Xiao Huang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 29, 2025

Water serves as the primary substance in all living cells and is an essential molecule involved numerous biological processes critical for maintaining homeostasis central nervous system (CNS). Disruptions water balance can occur conditions such cerebral edema, where fluid accumulation results increased intracranial pressure (ICP). Aquaporins (AQPs) are transmembrane proteins that play a vital role rapid transport of across cell membranes. Various subtypes AQPs (AQP1, AQP3, AQP4, AQP5, AQP6, AQP7, AQP8, AQP9, AQP11) have been identified brain tissue. This review summarizes latest advancements our understanding regulating edema. Abundant evidence indicates most prevalent AQP CNS, regulates contributes to both cytotoxic vasogenic suggesting AQP4 may serve potential therapeutic target Additionally, some studies indicated AQP1 plays significant formation cerebrospinal (CSF) maintenance steady-state ICP. However, date, these findings not translated into clinical practice. There urgent need develop specific inhibitors activators explore benefits modulating functions context

Language: Английский

Citations

0
Near-Infrared Imaging of Glymphatic Clearance in a Pre-Clinical Model of Repetitive Closed Head Traumatic Brain Injury DOI Creative Commons
Eleftheria Michalaki, Alexis N. Pulliam,

Pooja M. Datta Roy

et al.

Neurotrauma Reports, Journal Year: 2025, Volume and Issue: 6(1), P. 115 - 128

Published: Jan. 1, 2025

Traumatic brain injury (TBI) is a major health disorder for which there are few treatments. The glymphatic system the brain's inbuilt lymphatic-like that thought to be responsible clearing waste products from lymph nodes. Although evidence drainage crucial homeostasis, its role in TBI pathogenesis remains elusive. Here, we investigated how clearance altered following rats using real-time non-invasive imaging. Twenty-four hours repetitive closed-head or sham conditions, injected infrared dye intraventricularly and used near-infrared (NIR) imaging quantify signal intensity, intensity over time, appearance time of NIR different regions. yielded lower rate change lateral ventricle surrounding parietal cortex compared with indicating reduced cerebrospinal fluid perfusion. took significantly longer reach anterior regions brain, while perfusion posterior was faster animals. Aquaporin-4 (AQP4) expression 24 h after across all cortical examined ventral at coronal levels, suggesting complex relationship between AQP4 glymph function. Furthermore, revealed detectable cervical nodes (CLNs) animals but not animals, yet blood accumulation CLNs TBI-related extravascular removed through system. These data indicate disrupts normal efflux kinetics reduces CLNs, demonstrating restoring function may promising therapeutic target.

Language: Английский

Citations

0
Repetitive Low-Level Blast Exposure Alters Circulating Myeloperoxidase, Matrix Metalloproteinases, and Neurovascular Endothelial Molecules in Experienced Military Breachers DOI Open Access
Shawn G. Rhind, Maria Y. Shiu,

Catherine Tenn

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1808 - 1808

Published: Feb. 20, 2025

Repeated exposure to low-level blast overpressure, frequently experienced during explosive breaching and heavy weapons use in training operations, is increasingly recognised as a serious risk the neurological health of military personnel. Although research on underlying pathobiological mechanisms humans remains limited, this study investigated effects such circulating molecular biomarkers associated with inflammation, neurovascular damage, endothelial injury. Blood samples from breachers were analysed for myeloperoxidase (MPO), matrix metalloproteinases (MMPs), junctional proteins indicative blood-brain barrier (BBB) disruption including occludin (OCLN), zonula occludens-1 (ZO-1), aquaporin-4 (AQP4), syndecan-1 (SD-1). The results revealed significantly elevated levels MPO, MMP-3, MMP-9, MMP-10 compared unexposed controls, suggesting heightened oxidative stress, vascular Increased OCLN SD-1 further indicated BBB glycocalyx degradation breachers. These findings highlight potential chronic unit damage/dysfunction repeated underscore importance early targeted interventions-such reducing reinforcing integrity, managing inflammation-that could be essential mitigating long-term impairment exposure.

Language: Английский

Citations

0
Exploring the Shared Diagnostic Genes in IBD and Psoriasis through Bioinformatics and Experimental Assays DOI Creative Commons

Lichun Han,

Guangfu Lin,

Xiaodan Lv

et al.

International Journal of Medical Sciences, Journal Year: 2025, Volume and Issue: 22(7), P. 1680 - 1697

Published: March 3, 2025

Background: Inflammatory bowel disease (IBD) is a persistent, non-specific inflammation affecting the intestines. Psoriasis long-lasting inflammatory disorder of skin. There comorbidity correlation between IBD and psoriasis, but specific pathogenesis unclear. Materials methods: In this study, we analyzed datasets sourced from Gene Expression Omnibus (GEO) database, identified shared genes psoriasis through differential expression analysis weighted gene co-expression network (WGCNA). Then three machine learning algorithms were applied to identify diagnostic genes. Next, validation was evaluated with ROC curves, AUC determined. Subsequently, single sample set enrichment (ssGSEA) immune infiltration conducted. Furthermore, obtained potential drugs such as securinine in Drug Signature Database (DsigDB) 7 traditional Chinese medicines Coremine which might have therapeutic effects on psoriasis. Finally, confirmed colitis mice tissues RT-PCR, Western blot immunohistochemistry (IHC) methods. Results: The results showed that AQP9 had highest value for two diseases. values 93.681% UC, 89.629% CD,and 78.689% internal datasets. external datasets, 90.394% 93.909% 82.906% Immune ssGSEA revealed impact process by participating NF-kappaB signaling pathway, modulating cell differentiation. levels consistently validated, showing upregulation downregulation compared control group. Conclusions: This study mechanisms providing new directions future research exploring treatment targets.

Language: Английский

Citations

0
Exploring Aquaporins in Human Studies: Mechanisms and Therapeutic Potential in Critical Illness DOI Creative Commons
Charikleia S. Vrettou, Vasileios Issaris, Stelios Kokkoris

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1688 - 1688

Published: Dec. 20, 2024

Aquaporins (AQPs) are membrane proteins facilitating water and other small solutes to be transported across cell membranes. They crucial in maintaining cellular homeostasis by regulating permeability various tissues. Moreover, they regulate migration, signaling pathways, inflammation, tumor growth, metastasis. In critically ill patients, such as trauma, sepsis, patients with acute respiratory distress syndrome (ARDS), which frequently encountered intensive care units (ICUs), transport regulation is for homeostasis, dysregulation can lead edema or dehydration, the latter also implicating hemodynamic compromise. Indeed, AQPs involved fluid organs, including lungs, kidneys, brain, where their dysfunction exacerbate conditions like ARDS, kidney injury (AKI), cerebral edema. this review, we discuss implication of clinical entities ICUs, systemic inflammation AKI, brain due different types primary from a perspective. Current possible future therapeutic implications considered.

Language: Английский

Citations

0