Different Therapeutic Approaches for Dry and Wet AMD

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13053 - 13053

Published: Dec. 4, 2024

Age-related macular degeneration (AMD) is the most common cause of irreversible loss central vision in elderly subjects, affecting men and women equally. It a degenerative pathology that causes progressive damage to macula, vital part retina. There are two forms AMD depending on how macula damaged, dry wet or neovascular AMD. Dry form; waste materials accumulate under retina as old cells die, not being replaced. Wet less common, but can lead much more quickly. characterized by new abnormal blood vessels developing where they do normally grow. This frequently occurs patients who already have AMD, developed try solve problem. known what develop; however, certain risk factors (i.e., age, smoking, genetic factors) increase currently no treatments for evidence exercising regularly, eating nutritious food, taking supplements reduce acquiring slow its development. The main treatment inhibitors VEGF (vascular endothelial growth factor), protein stimulates vessels. stop vessels, preventing further loss. In patients, improve if diagnosed early treated accordingly. However, cannot repair has occurred. Current research trying find other options review provides summary current regarding different aimed at both with particular greater attention form.

Language: Английский

Phlorizin Protects Against Oxidative Stress and Inflammation in Age-Related Macular Degeneration Model

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 523 - 523

Published: April 3, 2025

Sweet Tea (Lithocarpus polystachyus Rehd.), a traditional ethnobotanical medicine, contains phlorizin, dihydrochalcone compound with antioxidative and anti-inflammatory properties. Given the critical role of oxidative stress inflammation in age-related macular degeneration (AMD), this study tested hypothesis that phlorizin mitigates damage AMD models, thereby offering therapeutic potential. Adult retinal pigmented epithelial cells (ARPE-19) were pre-treated (0.01-0.1 μM) subjected to induced by ultraviolet A (UVA) radiation or sodium iodate (NaIO3). Cell viability, reactive oxygen species (ROS) production, MAPK/NF-κB signaling, level pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) pro-angiogenic factors (VEGF, MMP2, MMP9) expression assessed using MTT assays, fluorescence imaging, Western blotting, RT-qPCR. In vivo, laser-induced choroidal neovascularization (CNV) mouse model was used evaluate phlorizin's effects on CNV formation vascular leakage via fundus photography angiography. Phlorizin significantly enhanced cell reduced ROS inhibited activation, downregulated inflammatory angiogenic mediators. vivo studies confirmed following treatment. demonstrated significant protective against inflammation, highlighting its potential for treating AMD.

Language: Английский

Machine learning model for age-related macular degeneration based on heavy metals: The National Health and Nutrition Examination Survey 2005 to 2008

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 6, 2024

Age-related macular degeneration (AMD) is the leading cause of blindness in older people developed countries. It has been suggested that heavy metal exposure may be associated with development AMD, but most studies have focused on effects a single traditional methods. In this study, we analyzed relationship between 13 urinary concentrations and AMD using NHANES data 2005 2008. We constructed compared 11 machine learning models to identify best model for predicting risk. further interpreted by Permutation Feature Importance (PFI), Partial Dependence Plot (PDP) analysis, SHapley Additive exPlanations (SHAP) analysis. 216 patients out 2380 participants. The random forest (RF) performed optimally risk an AUC value 0.970. PFI analyses revealed age cadmium (Cd) were main factors influencing AMD. SHAP confirmed significance Cd concentration significant interaction race. Our study firstly explored levels based techniques, found had greatest impact superior predictive performance Furthermore, our provided new perspective early screening intervention

Language: Английский