International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 285, P. 138287 - 138287
Published: Dec. 2, 2024
Language: Английский
Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 640 - 640
Published: Oct. 7, 2024
Hydrogels have garnered significant interest in the biomedical field owing to their tissue-like properties and capability incorporate various fillers. Among these, injectable hydrogels been highlighted for unique advantages, especially minimally invasive administration mode implantable use. These can be utilized pristine forms or as composites by integrating them with therapeutic filler materials. Given primary application platforms, enzymatically crosslinked actively explored due excellent biocompatibility easily controllable mechanical desired This review introduces crosslinking mechanisms of such hydrogels, focusing on those mediated horseradish peroxidase (HRP), transglutaminase (TG), tyrosinase. Furthermore, several parameters relationships intrinsic are investigated. Subsequently, representative applications crosslinked-injectable presented, including wound healing, preventing post-operative adhesion (POA), hemostasis. hydrogel containing materials, cells, proteins, drugs, analyzed. In conclusion, we examine scientific challenges directions future developments material selection, properties, integration.
Language: Английский
Citations
3
Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 842 - 842
Published: Dec. 20, 2024
This paper provides a solid foundation for understanding the synthesis, properties, and applications of cellulose-based gels. It effectively showcases potential these gels in diverse applications, particularly biomedicine, highlights key synthesis methods properties. However, to push field forward, future research should address gaps environmental impact, mechanical stability, scalability gels, while also considering how overcome barriers their industrial use. will ultimately allow realization large-scale, sustainable applications.
Language: Английский
Citations
2
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
Current wound dressings are insufficient in simultaneously addressing bacterial infections and oxidative stress, which severely affects healing outcomes. To solve this problem, we introduced poly(ionic liquid) (PIL) with strong antibacterial properties cerium oxide nanoparticles (CeO
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1531 - 1531
Published: Nov. 29, 2024
Background: Phyllanthus emblica is a medicinal and edible plant from the Euphorbiaceae family, notable for its rich content of polyphenols flavonoids, which provide significant antioxidant properties. To exploit full potential emblica, this study developed hydrogel system incorporating polyvinyl alcohol (PVA) carboxymethyl cellulose sodium (CMC-Na), integrated with extract, purpose wound healing. Methods: The extraction process active ingredients was optimized assessed composition activity extract. A series performance evaluations were performed on extract-loaded PVA/CMC-Na (AEPE composite hydrogel). Additionally, healing efficacy evaluated through cell culture experiments assays using BALB/C mice. Results: findings indicated that 95% ethanol yielded an extract in polyphenols, primarily gallic acid ellagic acid, demonstrating high free radical scavenging capacity robust activity. matrix containing 12% PVA 1% CMC-Na exhibited excellent physicochemical AEPE enabled sustained drug release over 24 h period, low cytotoxicity promoted migration. In mouse dorsal model, showed pronounced anti-inflammatory antioxidation effects, enhanced collagen deposition, ultimately accelerated Conclusions: demonstrated strong characteristics potential. Thus, could broaden application prospects
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 285, P. 138287 - 138287
Published: Dec. 2, 2024
Language: Английский
Citations
0