Intensive vs. Standard Systolic Blood Pressure Control in Type 2 Diabetes: A Retrospective Study

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(1), P. 50 - 57

Published: Jan. 16, 2025

Background: Systolic blood pressure (SBP) control is a critical aspect of managing Type 2 diabetes, which associated with an increased risk cardiovascular events. This retrospective study compares the effects intensive SBP (targeting < 120 mmHg) versus standard 140 on outcomes, mortality, and adverse in diabetes patients. Methods: A total 500 patients were included, 250 group group. Cardiovascular outcomes (heart attacks, strokes, mortality), (hypotension, hyperkalemia), medication adherence assessed. Cox proportional hazards regression was performed to evaluate effect risk. Results: The showed significantly lower incidence heart attacks (4.8% vs. 7.2%, p=0.03), strokes (3.2% 5.6%, p=0.02), mortality (2.4% 4.8%, p=0.04) compared However, had higher hyperkalemia (3.6% 1.2%, symptomatic hypotension (5.6% 3.2%, p=0.09). analysis revealed 21% reduced major events (HR = 0.79, 95% CI: 0.62-0.99, p=0.04). Conclusion: Intensive reduces diabetes. suggests that careful monitoring individualized treatment strategies are essential. Further prospective trials needed confirm these findings refine management guidelines for

Language: Английский

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Heart failure subphenotypes based on mean arterial pressure trajectory identify patients at increased risk of acute kidney injury

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: Jan. 19, 2025

Acute kidney injury (AKI) is a common complication in heart failure (HF) patients. Patients with who experience renal tend to have poor prognosis. The objective of this study examine the correlation between occurrence AKI patients and different mean arterial pressure (MAP) trajectories, goal improving early identification intervention for AKI. A retrospective was conducted on using data from Medical Information Mart Intensive Care IV (MIMIC-IV). We utilized group-based trajectory modeling (GBTM) method classify 24-hour MAP change trajectories within first 7 days intensive care unit (ICU) admission considered outcome. impact analyzed Cox proportional hazards models, competing risk doubly robust estimation methods. cohort 8,502 HF analyzed, their categorized into five groups: Low group (Class 1), Medium 2), Low-medium 3), High-to-low 4), High 5). results analysis revealed that Class 4 exhibited significantly increased than 3 (HR 1.284, 95% CI 1.085-1.521, p = 0.003; HR 1.271, 1.074-1.505, 0.005). Conversely, risks 2 were lower those 0.846, 0.745-0.960, 0.009; 0.879, 0.774-0.998, 0.047). influences rapid decrease 4) associated higher risk, while maintaining at moderate level 2) reduces risk. Therefore, closely monitoring changes crucial preventing HF.

Language: Английский

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Exploring the Link Between Cheese Consumption and Heart Failure Risk: A Mendelian Randomization Approach with Biomarker Analysis

Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Multiomics insight into the role of glucagon‐like peptide‐1 receptor agonists in heart failure

ESC Heart Failure, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Aims Cardiovascular diseases, such as atrial fibrillation, coronary artery disease, heart failure (HF) and ischaemic stroke, are leading causes of death globally exert major global health burden. Recent studies suggest that glucagon‐like peptide‐1 receptor agonists (GLP1Ra), a novel class antidiabetic drugs, may not only help manage blood glucose but also reduce the risks cardiovascular diseases. However, mechanisms through which GLP1Ra protects against remain incompletely understood. Methods results Genome‐wide association study dates were used to investigate impact on including fibrillation (1,202,168 European 28,612 East Asian), disease (501,756 183,134 (1,350,497 203,040 Asian) stroke (689,168 192,383 Asian). Genetic instruments selected from GLP1R gene region, two‐sample Mendelian randomization (MR) analyses conducted assess causal effects diseases in Asian populations. Summary‐data‐based MR performed for further validation using expression quantitative trait loci data. Mediation analysis evaluates role circulating inflammatory proteins metabolites mediating GLP1Ra. Meantime, we series sensitivity confirm robustness results. The result demonstrated significant between HF populations (odds ratio: 0.60, 95% CI 0.51–0.72, P = 2.76 × 10 −8 ), this was confirmed by SMR analyses. No associations found or all influence 27 146 metabolites. Among them, 4 17 associated with HF. indicated protective effect mediated fibroblast growth factor 5 (FGF5) N‐acetylglycine (NAC), proportion 4.37% 8% total effect, respectively. Conclusions This provides multiomics insight into especially underlying pathway. anti‐HF reducing concentration FGF5 increasing levels NAC, enriches potential alleviates

Language: Английский

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Renal Denervation in Heart Failure Treatment: Data for a Self-Fulfilling Prophecy

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6656 - 6656

Published: Nov. 6, 2024

Renal denervation (RDN), a transcatheter renal sympathetic nerve ablation procedure, is relatively novel established procedure for the treatment of hypertension, with it being recognized as third option hypertension management in most recent European guidelines, together pharmacotherapy, achieving blood pressure targets. Given relationship between both and overdrive development heart failure (HF), even studies at dawn research on RDN explored to overcome diuretic resistance those patients. As now that does not only have organ-specific but also systemic effects, several investigators aimed delineate whether could alter prognosis, symptoms, adverse events HF Data are available patients reduced preserved ejection fraction. significance neuromodulation gaining grounds therapeutic arsenal, this review, we aim provide rationale using an up-to-date overview data phenotypes, well discuss future neuromodulatory therapy management.

Language: Английский

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The Impact of Chemotherapy on Arterial Stiffness and Ventricular–Arterial Coupling in Women with Breast Cancer

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1115 - 1115

Published: Aug. 23, 2024

Background: The cardiac toxicity of chemotherapy for breast cancer is not uncommon and has been associated with elevated morbidity mortality. In the present study, we assessed impact on cardiovascular function by assessing cardio–ankle vascular index (CAVI), global longitudinal strain (GLS) ventricular–arterial coupling (VAC: CAVI/GLS ratio) in chemotherapy-treated women. Methods: This prospective study enrolled 78 women who were receiving anthracycline-based +/− anti-HER2 therapy (trastuzumab pertuzumab). Forty-one age-matched healthy served as controls. We comparatively evaluated left ventricular ejection fraction (LVEF), CAVI, GLS VAC, between control groups. also their changes over time (baseline, 3-month 6-month point) independent association incidence therapy-related dysfunction (CTRCD) group. Results: comparison to controls, presented significantly higher (from −21.02 ± 2.09% −19.01 2.81%, p < 0.001) VAC (−0.36 0.06 −0.41 0.11, 0.001). presence CTRCD was a further increase CAVI significant decline LVEF compared CTRCD-free (p Baseline, independently development during follow-up. Conclusion: Women undergoing displayed abnormal levels GLS, individuals. Those effects more exaggerated among CTRCD, implicating potential use refine screening therapeutic strategies this specific population.

Language: Английский

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