PCAT19: the role in cancer pathogenesis and beyond DOI Creative Commons

Haijun Hu,

Hongliang Luo, Ziqing Deng

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 18, 2024

PCAT19, a long non-coding RNA, has attracted considerable attention due to its diverse roles in various malignancies. This work compiles current research on PCAT19’s involvement cancer pathogenesis and progression. Abnormal expression of PCAT19 been observed cancers, correlation with clinical features prognosis positions it as promising prognostic biomarker. Additionally, ability effectively differentiate between tumor normal tissues suggests significant diagnostic value. exhibits dual nature, functioning either an oncogene or suppressor, depending the type. It is implicated range tumor-related activities, including cell proliferation, apoptosis, invasion, migration, metabolism, well growth metastasis. acts competing endogenous RNA (ceRNA) interacts proteins regulate critical cancer-related pathways, such MELK signaling, p53 cycle pathways. Furthermore, emerging evidence that plays role modulation neuropathic pain, adding complexity functional repertoire. By exploring molecular mechanisms pathways associated we aim provide comprehensive understanding multifaceted human health disease, highlighting potential therapeutic target for pain management.

Language: Английский

Ferroptosis in Endometriosis: Traditional Chinese Medicine Interventions and Mechanistic Insights DOI

Dazhi Lan,

Shuping Huang, Jing Li

et al.

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 27, 2025

Endometriosis (EMS) is a chronic, estrogen-dependent inflammatory disease affecting 5–10% of women reproductive age, characterized by the growth endometrial tissue on outside uterus. The dysregulation iron metabolism leads to accumulation ions at lesion sites, resulting in oxidative stress and pro-inflammatory responses that promote progression EMS. mechanisms underlying ferroptosis EMS primarily involve accumulation, lipid peroxidation, loss glutathione peroxidase 4 activity. These confer resistance within ectopic tissues facilitate cell survival proliferation. Traditional Chinese medicine (TCM) has demonstrated therapeutic potential for modulating ferroptosis. Studies have shown TCM monomers may regulate transport proteins anti-oxidant defense mechanisms. formulas employ distinct treatment strategies depending stage EMS: early stages, they control growth, whereas later inhibit reduce inflammation order improve health slow progression. This study provides new perspective management summarizing role its pathological reviewing findings use regulating

Language: Английский

Citations

0
Preoperative inflammatory pain exacerbates postoperative pain and neurocognitive impairment DOI Creative Commons
Hui Yuan, Daofan Sun, Bo Lu

et al.

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Many studies have shown that postoperative pain aggravates perioperative neurocognitive disorder (PND). In this study we aimed to clarify the effect of preoperative inflammatory on and cognitive function. We established model by injected complete freund adjuvant (CFA) PND tibial fracture surgery in 14- month-old C57BL/6 mice. The paw withdrawal threshold body weight mice were measured 7 days before 3 after surgery. On third day, subjected behavioral testing or sacrificed collect brain tissue. result shows CFA exacerbated dysfunction mice, enhanced surgery-induced activation microglia astrocytes hippocampus, increased overexpression IL-1β, IL-6, TNF-α, as well aggravated decreased expression α7nAChR HMGB1 hippocampus induced Our further aged rats, mechanism may be related neuroinflammation caused α7nAChR-mediated CAP high release HMGB1.

Language: Английский

Citations

0
Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus DOI Creative Commons
Juozas Rimantas Lazutka, Kristina Daniūnaitė,

Veronika Dedonytė

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1538 - 1538

Published: Nov. 16, 2024

Diabetes mellitus (DM) is a complex and heterogenous disease classified as group of metabolic disorders characterized by chronic hyperglycemia resulting from defects in insulin secretion, action, or both. It leads to various complications, some which are macrovascular microvascular like diabetic polyneuropathy (DPN), having profound impact on patients' quality life. Oxidative stress (OS) one the significant mechanisms development progression DPN. Thus, targeting OS pathways antioxidants, such α-lipoic acid (ALA), could represent promising therapeutic strategy for alleviating neuropathic symptoms. The aim our study was evaluate whether short-term (from 4 9 days) intravenous administration ALA cause any measurable improvement subjects with DM.

Language: Английский

Citations

0
PCAT19: the role in cancer pathogenesis and beyond DOI Creative Commons

Haijun Hu,

Hongliang Luo, Ziqing Deng

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 18, 2024

PCAT19, a long non-coding RNA, has attracted considerable attention due to its diverse roles in various malignancies. This work compiles current research on PCAT19’s involvement cancer pathogenesis and progression. Abnormal expression of PCAT19 been observed cancers, correlation with clinical features prognosis positions it as promising prognostic biomarker. Additionally, ability effectively differentiate between tumor normal tissues suggests significant diagnostic value. exhibits dual nature, functioning either an oncogene or suppressor, depending the type. It is implicated range tumor-related activities, including cell proliferation, apoptosis, invasion, migration, metabolism, well growth metastasis. acts competing endogenous RNA (ceRNA) interacts proteins regulate critical cancer-related pathways, such MELK signaling, p53 cycle pathways. Furthermore, emerging evidence that plays role modulation neuropathic pain, adding complexity functional repertoire. By exploring molecular mechanisms pathways associated we aim provide comprehensive understanding multifaceted human health disease, highlighting potential therapeutic target for pain management.

Language: Английский

Citations

0