The potential of novel arsenic nanoparticles containing metformin (MTF@As NPs): a study on their antioxidant and cytotoxic properties DOI Creative Commons
Mohammad Reza Shakibaie, Seyed Soheil Hosseininasab,

Soudabe Riahi-Madvar

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 28, 2025

In the present research, arsenic nanoparticles containing metformin (MTF@As NPs) were synthesized by subjecting a mixture of As2O3 and sodium borohydride solution to microwave irradiation in presence metformin. The physicochemical properties prepared analyzed using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray (EDS), scanning electron microscopy (SEM). assessed for their antioxidant potential, hemocompatibility, cytotoxic effects. Based on study's findings, it was found that MTF@As NPs have size range 14–38 nm. DPPH scavenging iron-reducing assays demonstrated exhibited significantly higher activity than As (80–1280 µg/mL). study also revealed compatible materials did not induce significant hemolysis RBCs. According study, concentration required death half cells (IC50) treated with after 24 h be 33.5 ± 2.6 µg/mL 5.7 0.3 MCF-7, NIH3T3 cells, respectively. Notably, toxicity against MCF-7 at concentrations (40–1280 This provides insights into NPs, additional investigation is necessary fully understand these nanoparticles' underlying biological mechanisms.

Language: Английский

The potential of novel arsenic nanoparticles containing metformin (MTF@As NPs): a study on their antioxidant and cytotoxic properties DOI Creative Commons
Mohammad Reza Shakibaie, Seyed Soheil Hosseininasab,

Soudabe Riahi-Madvar

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 28, 2025

In the present research, arsenic nanoparticles containing metformin (MTF@As NPs) were synthesized by subjecting a mixture of As2O3 and sodium borohydride solution to microwave irradiation in presence metformin. The physicochemical properties prepared analyzed using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray (EDS), scanning electron microscopy (SEM). assessed for their antioxidant potential, hemocompatibility, cytotoxic effects. Based on study's findings, it was found that MTF@As NPs have size range 14–38 nm. DPPH scavenging iron-reducing assays demonstrated exhibited significantly higher activity than As (80–1280 µg/mL). study also revealed compatible materials did not induce significant hemolysis RBCs. According study, concentration required death half cells (IC50) treated with after 24 h be 33.5 ± 2.6 µg/mL 5.7 0.3 MCF-7, NIH3T3 cells, respectively. Notably, toxicity against MCF-7 at concentrations (40–1280 This provides insights into NPs, additional investigation is necessary fully understand these nanoparticles' underlying biological mechanisms.

Language: Английский

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