The role of non-coding RNAs (ncRNAs) and their potential connection with cancer DOI Creative Commons

Safura Absalan,

Hamidreza Vaziri

Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 22, 2025

Abstract Cancer remains a significant global health challenge, claiming numerous lives annually and posing complex hurdles in management. The disease's multifaceted nature, combined with disparities healthcare infrastructure socioeconomic factors worldwide, complicates effective treatment. With alarming mortality rates, there is an urgent need to enhance prevention early detection strategies. Early not only enables less invasive treatments but also improves the chances of successful recovery, highlighting importance proactive approaches. Lung cancer ranks highest followed by breast, prostate, colon cancers. often seen as both "genetic disease," involving gene mutations, "environmental influenced various environmental affecting expression. Metabolic alterations are hallmark cancer, disruptions cellular stability function significantly contribute its progression. Non-coding RNAs (ncRNAs) play crucial regulatory roles across cancers, diverse structures functions. They act oncogenes or tumor suppressors depending on type, intricately modulating genetic epigenetic processes. Recent studies challenge perception ncRNAs' insignificance, revealing their substantial impact mechanisms. Indeed, ncRNAs connect networks, influencing vital protein effectors that dictate responses fate. Consequently, dysregulated pivotal role disease pathogenesis, acting either oncogenic drivers through aberrant expression

Language: Английский

Impact of Metabolites from Foodborne Pathogens on Cancer DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886

Published: Dec. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Language: Английский

Citations

12
Extrachromosomal circular DNA: a double-edged sword in cancer progression and age-related diseases DOI

Shadira Anindieta Irdianto,

Astari Dwiranti, Anom Bowolaksono

et al.

Human Cell, Journal Year: 2025, Volume and Issue: 38(2)

Published: Feb. 19, 2025

Language: Английский

Citations

0
The role of non-coding RNAs (ncRNAs) and their potential connection with cancer DOI Creative Commons

Safura Absalan,

Hamidreza Vaziri

Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 22, 2025

Abstract Cancer remains a significant global health challenge, claiming numerous lives annually and posing complex hurdles in management. The disease's multifaceted nature, combined with disparities healthcare infrastructure socioeconomic factors worldwide, complicates effective treatment. With alarming mortality rates, there is an urgent need to enhance prevention early detection strategies. Early not only enables less invasive treatments but also improves the chances of successful recovery, highlighting importance proactive approaches. Lung cancer ranks highest followed by breast, prostate, colon cancers. often seen as both "genetic disease," involving gene mutations, "environmental influenced various environmental affecting expression. Metabolic alterations are hallmark cancer, disruptions cellular stability function significantly contribute its progression. Non-coding RNAs (ncRNAs) play crucial regulatory roles across cancers, diverse structures functions. They act oncogenes or tumor suppressors depending on type, intricately modulating genetic epigenetic processes. Recent studies challenge perception ncRNAs' insignificance, revealing their substantial impact mechanisms. Indeed, ncRNAs connect networks, influencing vital protein effectors that dictate responses fate. Consequently, dysregulated pivotal role disease pathogenesis, acting either oncogenic drivers through aberrant expression

Language: Английский

Citations

0