The Janus Face of Oxidative Stress and Hydrogen Sulfide: Insights into Neurodegenerative Disease Pathogenesis

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 360 - 360

Published: March 19, 2025

Oxidative stress plays an essential role in neurodegenerative pathophysiology, acting as both a critical signaling mediator and driver of neuronal damage. Hydrogen sulfide (H2S), versatile gasotransmitter, exhibits similarly “Janus-faced” nature, potent antioxidant cytoprotective molecule at physiological concentrations, but becoming detrimental when dysregulated. This review explores the dual roles oxidative H2S normal cellular physiology focusing on disease progression. We highlight potential therapeutic opportunities for targeting redox sulfur-based systems diseases by elucidating intricate balance between these opposing forces.

Language: Английский

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The Effect of High Fat Diet and H2S Donor GYY-4137 on Vascular Function in Spontaneously Hypertensive Rats

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Metabolic syndrome is a growing global health burden, resulting in an urgent need for new therapeutic strategies. We evaluated the effects of 3 weeks treatment with slow-releasing H₂S donor GYY-4137 on adiposity, systolic blood pressure (sBP), plasma biochemical indices, vascular function and nitric oxide (NO) hydrogen sulfide (H₂S) pathways isolated thoracic aortas (TAs) mesenteric arteries (MAs) from spontaneously hypertensive rats (SHRs) fed high-fat diet (HFD) 8 weeks. Although HFD increased TAs relaxation, it induced cardiac remodeling, decreased adrenergic contraction, reduced NO participation vasoactive responses, NO-synthase (NOS) activity, altered expression endothelial NOS (reduced), inducible NOS, tumor necrosis factor alpha (TNFα) (both increased) proteins adiposity chemerin levels. Treatment sBP, improved relaxation MA, partially restored contractility TA, generally signaling, TNFα chemerin. Thus, slow H₂S-releasing could ameliorate metabolic changes by fat intake during essential hypertension trigger beneficial associated restoration signaling suppression inflammation.

Language: Английский

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Hydrogen Sulfide (H2S)-Donor Molecules: Chemical, Biological, and Therapeutical Tools

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7932 - 7932

Published: July 20, 2024

This Special Issue aims to gather new research on hydrogen sulfide (H2S)-releasing compounds (Figure 1) as cutting-edge pharmacological tools and advance the understanding of critical role that H2S plays in physiological pathological processes [...].

Language: Английский

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