Improving the Push-Out Bond Strength of Fiber Posts in Diabetic Dentin: The Role of Chlorexidine Irrigation and Resin Cements DOI Creative Commons
Beyza Arslandaş Dinçtürk, Arzu Şahin Mantı, Cemile Kedıcı

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 16(1), P. 4 - 4

Published: Dec. 25, 2024

This study evaluated the effect of resin cements and post-space irrigation solutions on push-out bond strength diabetic non-diabetic dentin. A total 160 human central teeth (80 diabetic, 80 non-diabetic) were prepared using X5 files obturated with AH Plus sealer gutta-percha. Post spaces prepared, divided into eight groups based (Variolink N, Panavia SA Universal) protocols (saline, saline + 2% CHX). 1 mm slice from each tooth's middle third was tested for strength. Statistical analysis performed three-way ANOVA Tukey HSD tests. In dentin, CHX Variolink N achieved highest Universal resulted in lowest (p < 0.05). The dentin type, cement, solution significantly impacted fiber post strength, improved it.

Language: Английский

Multifaceted Roles of Vitamin D for Diabetes: From Immunomodulatory Functions to Metabolic Regulations DOI Open Access
Chan Yoon Park, Sunhye Shin, Sung Nim Han

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3185 - 3185

Published: Sept. 20, 2024

Numerous studies have established associations between vitamin D and diabetes. The receptor is widely distributed throughout the human body, including in pancreatic beta cells (β-cells), hepatocytes, immune cells. Therefore, D’s effect on risk, progression, or complications of diabetes may be mediated through various mechanisms. These include regulation insulin secretion sensitivity modulation β-cell function its immunomodulatory anti-inflammatory effects. This review extensively explores relationship status diabetes, as well preventive therapeutic effects supplementation from studies. Additionally, it examines detail impact inflammatory responses diabetic milieux to better understand underlying mechanisms which influences

Language: Английский

Citations

6
Causal relationship between immune cells, metabolites and polycystic ovary syndrome identified by Mendelian randomization and mediation analyses DOI Open Access
Lan Li, Mo Yang,

Ximing Yu

et al.

Immunology and Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Immune cells and blood metabolites play essential roles in the development of polycystic ovary syndrome (PCOS); however, it remains unclear whether mediate causal relationship between immune PCOS. This study aimed to delineate relationships among cells, PCOS potential through Mendelian randomization (MR). A two-sample MR analysis was conducted using inverse variance weighting as primary method determine causation risk. supplemented by a two-step assess mediating role In addition, series sensitivity methods were employed test robustness results. We also performed reverse evaluate possibility relationships. Our findings identified 22 cell phenotypes causally linked PCOS, with 12 acting risk factors 10 protective for Furthermore, 45 or ratios related Mediation revealed that X-25519 levels mediated 9.2% absolute count CD28-CD25++ CD8br N-acetylglucosamine/n-acetylgalactosamine adenosine 5'-monophosphate 6.7% -11.1%, respectively, naive DN(CD4- CD8-) %T The aspartate-to-citrate ratio 8.6% CD20- CD38- %B Finally, studies did not identify any elucidates links highlighting four interaction thus providing new targets research therapeutic interventions.

Language: Английский

Citations

0
Identification of antibiotic resistance profiles in diabetic foot infections: A machine learning proof-of-concept analysis DOI
Rodrigo M. Carrillo‐Larco,

Edmundo de Elvira Mori Orrillo,

Manuel Castillo-Cara

et al.

International Journal of Diabetes in Developing Countries, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

0
Astragaloside IV Relieves Mitochondrial Oxidative Stress Damage and Dysfunction in Diabetic Mice Endothelial Progenitor Cells by Regulating the GSK-3β/Nrf2 Axis DOI

Xiaoling Zou,

Xiangnan Liu,

Wenjing Qu

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Prophylactic vaccination strategies for adult patients with diabetes: a narrative review of safety profiles and clinical effectiveness DOI Creative Commons
Olivia Cicilia Walewangko,

Jonathan Suciono Purnomo,

Pranasha Amabella Jo

et al.

Clinical and Experimental Vaccine Research, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 1, 2025

This narrative review analyzed roles of several prophylactic vaccinations in adult patients with diabetes, focusing on their safety profiles and clinical effectiveness. Individuals diabetes mellitus are at increased risk for infections, making vaccination a critical component healthcare. The assessed various vaccines that particularly relevant this population, i.e., pneumococcus, meningococcus, severe acute respiratory syndrome coronavirus 2, influenza, herpes zoster, human papillomavirus, dengue. It highlighted the effectiveness these preventing serious infections improving long-term health outcomes diabetic patients. Taken together, emphasized importance reducing infection-related morbidity mortality as well encouraged fostering greater adoption advocacy immunization programs among adults.

Language: Английский

Citations

0
Glycemic control and vaccine response: the role of mucosal immunity after vaccination in diabetic patients DOI Creative Commons
Moaz Mojaddidi, Moutasem Salih Aboonq, Saeed Awad M. Alqahtani

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

This review explores the critical interplay between glycemic control, mucosal immunity, and vaccine response in diabetic patients. Diabetes mellitus, characterized by impaired glucose regulation, significantly impacts immune function, particularly at surfaces. Poor control diminishes vaccine-induced antibody responses compromises defenses, such as secretory IgA production, increasing susceptibility to infections. We synthesize evidence highlighting importance of optimizing management prior vaccination enhance immunogenicity. Furthermore, we examine potential personalized strategies, tailored individual status, age, BMI, kidney improve efficacy this vulnerable population. Additionally, discuss role adjunct therapies, including probiotics, nutritional interventions, lifestyle modifications, modulating gut microbiota reinforcing barrier integrity. underscores necessity for an interdisciplinary approach, integrating metabolic with innovative designs, maximize protection against infectious diseases Future research should prioritize longitudinal studies assessing both systemic immunity refine strategies ensure robust durable protection.

Language: Английский

Citations

0
Clinical and Microbiological Periodontal Biofilm Evaluation of Patients with Type I Diabetes DOI Open Access

Mihaela Mariş,

Maria-Alexandra Mârțu, Marius Mariş

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6724 - 6724

Published: Nov. 8, 2024

The purpose of this study was to assess the microbial composition and density subgingival plaque samples for periodontal pathogens while correlating values with glycemic control levels via glycated hemoglobin (HbA1c), a type that has chemically linked glucose, in I diabetes individuals who will undergo complex oral rehabilitation through orthodontic treatment implant surgery.

Language: Английский

Citations

1
Diabetic Mice Spleen Vulnerability Contributes to Decreased Persistence of Antibody Production after SARS-CoV-2 Vaccine DOI Open Access

Yara Atef,

T. Ito, Akitsu Masuda

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10379 - 10379

Published: Sept. 26, 2024

During the COVID-19 pandemic, diabetic and obese patients experienced higher rates of hospital admissions, severe illness, mortality. However, vaccinations failed to provide those vulnerable populations same level protection against severity as without phenotypes. Our study aimed investigate how diabetes mellitus (DM) impacts immune response following vaccination including artificially designed trimeric SARS-CoV-2 spike (S)-protein. By using two mouse models, ob/ob mice (obese, hyperglycemic, insulin-resistant) STZ-treated (insulin-deficient hyperglycemic), we observed a significant reduction in S-protein-specific IgG antibody titer post-vaccination both models compared wild-type (WT) mice. Both exhibited abnormalities spleen tissue, marked reductions splenic weight size white pulp regions. Furthermore, T-cell B-cell zones were notably diminished, suggesting an underlying dysfunction that could contribute impaired production. Notably, with S-protein, when paired optimal adjuvant, did not exacerbate cardiomyopathy, blood glucose levels, or liver function, providing reassurance about vaccine′s safety. These findings offer valuable insights into potential mechanisms responsible for decreased persistence production patients.

Language: Английский

Citations

0
Focal Segmental Glomerulosclerosis With Superimposed Infection‐Related Glomerulonephritis in a Diabetic Patient: A Case of Rapid Renal Decline DOI Creative Commons
Mahyar Toofantabrizi,

S. Armağan,

Suchitra Shrestha

et al.

Clinical Case Reports, Journal Year: 2024, Volume and Issue: 12(11)

Published: Nov. 1, 2024

Language: Английский

Citations

0
Improving the Push-Out Bond Strength of Fiber Posts in Diabetic Dentin: The Role of Chlorexidine Irrigation and Resin Cements DOI Creative Commons
Beyza Arslandaş Dinçtürk, Arzu Şahin Mantı, Cemile Kedıcı

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 16(1), P. 4 - 4

Published: Dec. 25, 2024

This study evaluated the effect of resin cements and post-space irrigation solutions on push-out bond strength diabetic non-diabetic dentin. A total 160 human central teeth (80 diabetic, 80 non-diabetic) were prepared using X5 files obturated with AH Plus sealer gutta-percha. Post spaces prepared, divided into eight groups based (Variolink N, Panavia SA Universal) protocols (saline, saline + 2% CHX). 1 mm slice from each tooth's middle third was tested for strength. Statistical analysis performed three-way ANOVA Tukey HSD tests. In dentin, CHX Variolink N achieved highest Universal resulted in lowest (p < 0.05). The dentin type, cement, solution significantly impacted fiber post strength, improved it.

Language: Английский

Citations

0