Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration DOI Creative Commons
Jiaxiang Zhang,

Liangrui Chen,

Jialu Yu

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 3, 2024

Periodontitis is one of the most prevalent oral diseases leading to tooth loss in adults, and characterized by destruction periodontal supporting structures. Traditional therapies for periodontitis cannot achieve ideal regeneration tissue. Mesenchymal stem cells (MSCs) represent a promising approach tissue regeneration. Recently, prominent role MSCs this context has been attributed microRNAs (miRNAs), which participate post-transcriptional regulation are crucial various physiological pathological processes. Additionally, they function as indispensable elements extracellular vesicles, protect them from degradation. In periodontitis, MSCs-derived miRNAs play pivotal cellular proliferation differentiation, angiogenesis tissues, regulating autophagy, providing anti-apoptotic effects, mediating inflammatory microenvironment. As cell-free strategy, their small size ability target related sets genes regulate signaling networks predispose become candidates This review aims introduce summarize potential functions mechanisms repair

Language: Английский

Frontier progress and translational challenges of pluripotent differentiation of stem cells DOI Creative Commons

Zhengbing Su,

Hui Dong, Xiang Fang

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Stem cell research has significantly transformed regenerative medicine, with pluripotent stem cells (PSCs) serving as the cornerstone for disease modeling, drug screening, and therapeutic applications. Embryonic (ESCs) exhibit unparalleled self-renewal tri-lineage differentiation, while induced (iPSCs) bypass ethical constraints through somatic reprogramming. Clinical trials highlight potential of mesenchymal (MSCs) in osteoarthritis graft-versus-host disease, which leverage their immunomodulatory paracrine effects. Despite advancements, challenges persist: iPSCs face epigenetic instability tumorigenic risks, adult struggle inefficient differentiation. This paper systematically reviews source classification, differentiation regulatory mechanisms, cutting-edge technologies such CRISPR/Cas9, explores field-specific controversies (e.g., stability iPSCs) future directions integration organoids biomaterials). By analyzing current progress challenges, it provides a multidimensional perspective research.

Language: Английский

Citations

0
Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration DOI Creative Commons
Jiaxiang Zhang,

Liangrui Chen,

Jialu Yu

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 3, 2024

Periodontitis is one of the most prevalent oral diseases leading to tooth loss in adults, and characterized by destruction periodontal supporting structures. Traditional therapies for periodontitis cannot achieve ideal regeneration tissue. Mesenchymal stem cells (MSCs) represent a promising approach tissue regeneration. Recently, prominent role MSCs this context has been attributed microRNAs (miRNAs), which participate post-transcriptional regulation are crucial various physiological pathological processes. Additionally, they function as indispensable elements extracellular vesicles, protect them from degradation. In periodontitis, MSCs-derived miRNAs play pivotal cellular proliferation differentiation, angiogenesis tissues, regulating autophagy, providing anti-apoptotic effects, mediating inflammatory microenvironment. As cell-free strategy, their small size ability target related sets genes regulate signaling networks predispose become candidates This review aims introduce summarize potential functions mechanisms repair

Language: Английский

Citations

1