Evaluation of the Use of Cell Lines in Studies of Selenium-Dependent Glutathione Peroxidase 2 (GPX2) Involvement in Colorectal Cancer DOI Creative Commons
R. Steven Esworthy

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 207 - 207

Published: Sept. 10, 2024

Hydroperoxides (ROOHs) are known as damaging agents capable of mediating mutation, while a role signaling through oxidation protein sulfhydryls that can alter cancer-related pathways has gained traction. Glutathione peroxidase 2 (GPX2) is an antioxidant enzyme reduces ROOHs at the expense glutathione (GSH). GPX2 noted for tendency large increases or decreases in expression levels during tumorigenesis leads to investigators focusing on its cancer. However, only one component multiple families metabolize ROOH, and often very low context these other ROOH-reducing activities. Colorectal cancer (CRC) was selected case study examining function, colorectal tissues cancers sites where

Language: Английский

Mechanisms of ferroptosis sensitization and resistance DOI
Weaverly Colleen Lee, Scott J. Dixon

Developmental Cell, Journal Year: 2025, Volume and Issue: 60(7), P. 982 - 993

Published: April 1, 2025

Language: Английский

Citations

1
Understanding Selenoproteins: Structural insights, biological functions and transformative applications in therapeutics DOI

Bhairav Prasad,

Akanksha Akanksha,

Palki Sahib Kaur

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Understanding the role of tRNA modifications in UGA recoding as selenocysteine in eukaryotes DOI
Laurent Chavatte,

L F De Lange,

Ulrich Schweizer

et al.

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169017 - 169017

Published: Feb. 1, 2025

Language: Английский

Citations

0
Enzymatic Oxidants, Antioxidants, and Inflammatory Bowel Disease DOI Creative Commons
R. Steven Esworthy

Applied Biosciences, Journal Year: 2025, Volume and Issue: 4(2), P. 19 - 19

Published: April 1, 2025

The role of oxidants and antioxidants in inflammatory bowel disease (IBD) has been actively explored since the early 1980s, starting with respiratory burst neutrophils ischemia pathology. Since that time, enzymatic components contributing to pool reactive oxygen species, including superoxide, H2O2, lipid hydroperoxides, counteracting antioxidants—catalase, glutathione peroxidases (Gpx), peroxiredoxins (PRDX), superoxide dismutases, others—have fleshed out. My perspective on IBD is from balance or imbalance oxidant sources process. I will present evidence involvement antioxidant processes based, as much possible, my experiences Gpxs. This be discussed terms both immune system local systems. As Gpxs are generally selenium-dependent, possible deficiencies selenium uptake active impact Gpx expression explored. more recently introduced ferroptosis, an iron-dependent peroxidation-based pathological process, reviewed for its IBD.

Language: Английский

Citations

0
Evaluation of the Use of Cell Lines in Studies of Selenium‐Dependent Glutathione Peroxidase 2 (GPX2) Involvement in Colorectal Cancer DOI Open Access
R. Steven Esworthy

Published: Sept. 2, 2024

Hydroperoxides (ROOH) are known as damaging agents capable of mediating mutation, while a role signaling through oxidation protein sulfhydryls that can alter cancer-related pathways has gained traction. Glutathione peroxidase 2 (GPX2) is an antioxidant enzyme reduces ROOH at the expense glutathione (GSH). GPX2 noted for tendency large in-creases or decreases in expression levels during tumorigenesis leads to investigators focusing on its cancer. However, only one component multiple families metabolize and often very low context these other reducing activities. Colorectal cancer (CRC) was selected case study examining function colorectal tissues cancers sites where highly expressed. A be made significant impact changes levels. There also link between NADPH oxidase 1 (NOX1) from earlier studies seldom addressed discussed, presenting data unique association colon CRC. Tumor-derived cell lines quite commonly used pre-clinical involving Generally, selection this type work limited identifying based high with standard re-search scheme overexpression expressing suppression identify impacted pathways. This overlooks CRC subtypes among wide range gene profiles variety driver mutation differences along difference trend segregate into different subclasses, indicated report, suggests choices solely may provide misleading conflicting results by disregarding properties failing factor potential targets ROOH. line classification schemes presented here were intended assist workers performing but largely unnoted Studies initiated premise transition normal associated up-regulation GPX2. probably correct. source cells could almost any type, some These factors study.

Language: Английский

Citations

0
Evaluation of the Use of Cell Lines in Studies of Selenium-Dependent Glutathione Peroxidase 2 (GPX2) Involvement in Colorectal Cancer DOI Creative Commons
R. Steven Esworthy

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 207 - 207

Published: Sept. 10, 2024

Hydroperoxides (ROOHs) are known as damaging agents capable of mediating mutation, while a role signaling through oxidation protein sulfhydryls that can alter cancer-related pathways has gained traction. Glutathione peroxidase 2 (GPX2) is an antioxidant enzyme reduces ROOHs at the expense glutathione (GSH). GPX2 noted for tendency large increases or decreases in expression levels during tumorigenesis leads to investigators focusing on its cancer. However, only one component multiple families metabolize ROOH, and often very low context these other ROOH-reducing activities. Colorectal cancer (CRC) was selected case study examining function, colorectal tissues cancers sites where

Language: Английский

Citations

0