Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis

Current Research in Food Science, Journal Year: 2025, Volume and Issue: 10, P. 100972 - 100972

Published: Jan. 1, 2025

Resveratrol (RES), a natural polyphenolic compound, has shown promise in enhancing skeletal muscle regeneration and metabolic function. This study aims to explore the impact of RES on after injury through regulation antioxidant capacity mitochondrial biogenesis. treatment significantly increased ratio tibialis anterior mass body weight, alongside reduced fasting glucose levels. Following cardiotoxin-induced injury, improved regeneration, characterized by greater formation new fibers better structural repair compared control. Notably, gene expression analyses demonstrated that RES-treated mice exhibited elevated levels myogenic markers, such as paired box 7 (Pax7), factor 5 (Myf5), myoblast determination protein (MyoD), Myogenin (MyoG). Concurrently, yes-associated (YAP) increased, underscoring its role regulating satellite cell activity. Transcriptomic analysis identified enriched pathways related biogenesis, with transcription factors higher DNA content mice. Furthermore, enhanced via Kelch-like ECH-associated 1 (KEAP-1)/nuclear erythroid 2-related 2 (NRF2)/heme oxygenase-1 (HO-1) signaling pathway, indicated activities total capacity, Glutathione peroxidase (GSH-PX), superoxidase dismutase (SOD). Collectively, these findings suggest not only promotes but also supports function defenses, positioning it food-derived pharmaceutical for targeting injury.

Language: Английский

Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

Preparation of Rutin–Whey Protein Pickering Emulsion and Its Effect on Zebrafish Skeletal Muscle Movement Ability

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3050 - 3050

Published: Sept. 10, 2024

Nutritional supplementation enriched with protein and antioxidants has been demonstrated to effectively strengthen skeletal muscle function mitigate the risk of sarcopenia. Dietary also a common carrier establish bioactive delivery system. Therefore, in this study, Pickering emulsion system for rutin was constructed whey protein, its structural characteristics, bioaccessibility, molecular interactions were investigated. In vivo zebrafish (n = 10 each group), which have high genetic homology humans, treated dexamethasone induce sarcopenia symptoms administered rutin, emulsion, respectively, movement ability evaluation, or without used as model control groups, respectively. Results showed that homogeneous particle size encapsulation rate 71.16 ± 0.15% loading efficiency 44.48 0.11%. Rutin exhibited significantly higher bioaccessibility than free form. The interaction forces between two components proteins (α-LA β-LG) mainly van der Waals hydrogen bonds. After treatment 96 h, Picking groups increased high-speed time frequency, an level ATP, prolonged peripheral motor nerve length, normalized muscular histological structure compared those group (p < 0.05). results study developed new strategy utilization provide scientific evidence prevention food-derived resource.

Language: Английский