Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs DOI
Gurinderdeep Singh,

Ronald Darwin,

Krishna Chandra Panda

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 36

Published: Dec. 27, 2024

Osteoporosis is well noted to be a universal ailment that realization impaired bone mass and micro architectural deterioration thus enhancing the probability of fracture. Despite its high incidence, management remains highly demanding because multifactorial pathophysiology disease. This review highlights recent findings in osteoporosis particularly, gene expression hormonal control. Some newest approaches regarding subject are described, including single-cell RNA sequencing long non-coding RNAs. Also, reflects new on signaling estrogen parathyroid hormone; patient-specific due genetic variation. Potential biomarkers AI comprised as factors for improving ability anticipate manage fractures. These hold great potential drugs, combination therapies based future. Further studies cooperation scientists clinicians will help apply such novelties into practical uses sphere medicine order enhance treatment patients with osteoporosis.

Language: Английский

Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs DOI
Gurinderdeep Singh,

Ronald Darwin,

Krishna Chandra Panda

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 36

Published: Dec. 27, 2024

Osteoporosis is well noted to be a universal ailment that realization impaired bone mass and micro architectural deterioration thus enhancing the probability of fracture. Despite its high incidence, management remains highly demanding because multifactorial pathophysiology disease. This review highlights recent findings in osteoporosis particularly, gene expression hormonal control. Some newest approaches regarding subject are described, including single-cell RNA sequencing long non-coding RNAs. Also, reflects new on signaling estrogen parathyroid hormone; patient-specific due genetic variation. Potential biomarkers AI comprised as factors for improving ability anticipate manage fractures. These hold great potential drugs, combination therapies based future. Further studies cooperation scientists clinicians will help apply such novelties into practical uses sphere medicine order enhance treatment patients with osteoporosis.

Language: Английский

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