Mechanistic and Therapeutic Insights into Flavonoid-Based Inhibition of Acetylcholinesterase: Implications for Neurodegenerative Diseases DOI Open Access
Natalia Cichoń, Weronika Grabowska, Leslaw Gorniak

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 78 - 78

Published: Dec. 28, 2024

Flavonoids are naturally occurring polyphenolic compounds known for their extensive range of biological activities. This review focuses on the inhibitory effects flavonoids acetylcholinesterase (AChE) and potential as therapeutic agents cognitive dysfunction. AChE, a serine hydrolase that plays crucial role in cholinergic neurotransmission, is key target treatment impairments due to its function acetylcholine hydrolysis. Natural compounds, particularly flavonoids, have demonstrated significant inhibition positioning them promising alternatives or adjuncts neuropharmacology. study specifically examines such quercetin, apigenin, kaempferol, naringenin, investigating efficacy, binding mechanisms, additional neuroprotective properties, including antioxidant anti-inflammatory effects. In vitro, vivo, silico analyses reveal these effectively interact with both active peripheral anionic sites resulting increased levels stabilization signaling. Their mechanisms action extend beyond mere enzymatic inhibition, they also exhibit anti-amyloidogenic thereby offering multifaceted approach neuroprotection. Given findings, hold considerable modulators implications enhancing treating neurodegenerative diseases. Future studies should prioritize enhancement flavonoid bioavailability, evaluate efficacy clinical settings, explore synergistic when combined established therapies fully harness neurotherapeutic agents.

Language: Английский

Multifunctional Roles and Phytopharmacological Potential of Ursolic Acid: an Invaluable Natural Nutraceutical Agent DOI
Pranay Wal,

Shubhi Kaushal,

Jyotsana Dwivedi

et al.

Russian Journal of Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 51(1), P. 1 - 34

Published: Feb. 1, 2025

Language: Английский

Citations

0
Resource utilization of tea waste in biochar and other areas: Current status, challenges and future prospects DOI

Liting Hao,

Ziheng Zhao,

Hongliang Zhou

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 377, P. 124569 - 124569

Published: Feb. 20, 2025

Language: Английский

Citations

0
Cancer prevention: past challenges and future directions DOI Creative Commons

HeeKyung Seong,

Runa Izutsu,

Mitsuhiko Osaki

et al.

Genes and Environment, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 27, 2025

Abstract Almost 70 years have passed since the molecular mechanism of carcinogenesis was hypothesized to involve multiple gene mutations. More than 1,000 cancer-related genes, including oncogenes and tumor suppressor accelerate by altering functions expression through mutations epigenetic changes been shown cause multistep in several organ cancers. The elucidation abnormalities has led development molecular-targeted therapies that focus on driver molecules, known as precision medicine, addition conventional treatments such surgery, radiotherapy, chemotherapy. Now cancer largely elucidated, options for treatment its outcomes improved, research is moving next stage: prevention. Cancer prevention using chemicals first proposed approximately 50 ago. It concept stabilizing, arresting, or reverting precancerous lesions normal tissues synthetic vitamin A analogs (retinoids). chemoprevention now considered consist three elements: “primary prevention,” which prevents tumors benign converting into more malignant ones; “secondary aims early detection screening treatment; “tertiary reduces risk recurrence extends time until death from treatment. Consequently, there no clear boundary between strategies. Therefore, targets entire process, cells lesions, progression tumors, cancer. Basic clinical revealed influenced race, regional, national differences, well individual differences genetic factors, environmental lifestyle habits. This review provides an overview progress made summarizes future directions.

Language: Английский

Citations

0
Dietary Triterpenoids in Functional Food and Drug Ingredients: a review of structure-activity relationships, biosynthesis, applications, and AI-driven strategies DOI
Chao Fang, Haixia Yang, Daidi Fan

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104961 - 104961

Published: March 1, 2025

Language: Английский

Citations

0
Phytochemicals Modulate Biosynthesis and Function of Serotonin, Dopamine, and Norepinephrine for Treatment of Monoamine Neurotransmission-Related Psychiatric Diseases DOI Open Access
Makoto Naoi,

Yuqiu Wu,

Wakako Maruyama

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2916 - 2916

Published: March 23, 2025

Serotonin (5-HT), dopamine (DA), and norepinephrine (NE) are key monoamine neurotransmitters regulating behaviors, mood, cognition. 5-HT affects early brain development, its dysfunction induces vulnerability to stress, raising the risk of depression, anxiety, autism in adulthood. These synthesized from tryptophan tyrosine via hydroxylation decarboxylation, metabolized by oxidase (MAO). This review aims summarize current findings on role dietary phytochemicals modulating neurotransmitter biosynthesis, metabolism, function, with an emphasis their potential therapeutic applications neuropsychiatric disorders. Phytochemicals exert antioxidant, neurotrophic, neurohormonal activities, regulate gene expression, induce epigenetic modifications. Phytoestrogens activate estrogen receptors or estrogen-responsive elements promoter target genes, enhance transcription hydroxylase hydroxylase, while inhibiting that MAO. compounds also influence interaction between genetic environmental factors, potentially reversing dysregulated neurotransmission architecture associated conditions. Despite promising preclinical findings, clinical remain challenging. Advances nanotechnology targeted delivery systems offer solutions efficacy. discusses mechanisms, challenges, strategies, underscoring need for further research advance phytochemical-based interventions diseases.

Language: Английский

Citations

0
Aptamers as Diagnostic and Therapeutic Agents for Aging and Age-Related Diseases DOI Creative Commons
Tae-In Park, A. Yang,

Bashistha Kumar Kanth

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(4), P. 232 - 232

Published: April 5, 2025

In the 21st century, demographic shift toward an aging population has posed a significant challenge, particularly with respect to age-related diseases, which constitute major threat human health. Accordingly, detection, prevention, and treatment of diseases have become critical issues, introduction novel molecular recognition elements, called aptamers, been considered. Aptamers, class oligonucleotides, can bind target molecules high specificity. addition, aptamers exhibit superior stability, biocompatibility, applicability, rendering them promising tools for diagnosis diseases. this paper, we present comprehensive overview systematic evolution ligands by exponential enrichment (SELEX), biomarkers associated aging, as well aptamer-based diagnostic therapeutic platforms. Finally, limitations predicting preventing conditions are discussed, along potential solutions based on advanced technologies theoretical approaches.

Language: Английский

Citations

0
Marine-Derived Bioactive Ingredients in Functional Foods for Aging: Nutritional and Therapeutic Perspectives DOI Creative Commons
Youngji Han, Dong Hyun Kim, Seung Pil Pack

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(11), P. 496 - 496

Published: Nov. 4, 2024

Aging is closely linked to various health challenges, including cardiovascular disease, metabolic disorders, and neurodegenerative conditions. This study emphasizes the critical role of bioactive compounds derived from marine sources, such as antioxidants, omega-3 fatty acids, vitamins, minerals, polysaccharides, in addressing oxidative stress, inflammation, disorders related aging. Incorporating these materials into functional foods not only provides essential nutrients but also delivers therapeutic effects, thereby promoting healthy aging mitigating age-related diseases. The growth global anti-aging market, particularly North America, Europe, Asia, underscores significance this study. review systematically analyzes current research, identifying key compounds, their mechanisms action, potential benefits, thus highlighting broad applicability marine-derived enhancing improving quality life populations.

Language: Английский

Citations

1
Mechanistic and Therapeutic Insights into Flavonoid-Based Inhibition of Acetylcholinesterase: Implications for Neurodegenerative Diseases DOI Open Access
Natalia Cichoń, Weronika Grabowska, Leslaw Gorniak

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 78 - 78

Published: Dec. 28, 2024

Flavonoids are naturally occurring polyphenolic compounds known for their extensive range of biological activities. This review focuses on the inhibitory effects flavonoids acetylcholinesterase (AChE) and potential as therapeutic agents cognitive dysfunction. AChE, a serine hydrolase that plays crucial role in cholinergic neurotransmission, is key target treatment impairments due to its function acetylcholine hydrolysis. Natural compounds, particularly flavonoids, have demonstrated significant inhibition positioning them promising alternatives or adjuncts neuropharmacology. study specifically examines such quercetin, apigenin, kaempferol, naringenin, investigating efficacy, binding mechanisms, additional neuroprotective properties, including antioxidant anti-inflammatory effects. In vitro, vivo, silico analyses reveal these effectively interact with both active peripheral anionic sites resulting increased levels stabilization signaling. Their mechanisms action extend beyond mere enzymatic inhibition, they also exhibit anti-amyloidogenic thereby offering multifaceted approach neuroprotection. Given findings, hold considerable modulators implications enhancing treating neurodegenerative diseases. Future studies should prioritize enhancement flavonoid bioavailability, evaluate efficacy clinical settings, explore synergistic when combined established therapies fully harness neurotherapeutic agents.

Language: Английский

Citations

0