3D Models Currently Proposed to Investigate Human Skin Aging and Explore Preventive and Reparative Approaches: A Descriptive Review DOI Creative Commons
Francesca Lombardi, Francesca Rosaria Augello, Alessia Ciafarone

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1066 - 1066

Published: Aug. 26, 2024

Skin aging is influenced by intrinsic and extrinsic factors that progressively impair skin functionality over time. Investigating the process requires thorough research using innovative technologies. This review explores use of in vitro human 3D culture models, serving as valuable alternatives to animal ones, research. The aim highlight benefits necessity improving methodology analyzing molecular mechanisms underlying aging. Traditional 2D including monolayers keratinocytes, fibroblasts, or melanocytes, even if providing cost-effective straightforward methods study critical processes such extracellular matrix degradation, pigmentation, effects secretome on cells, fail replicate complex tissue architecture with its intricated interactions. Advanced models (organoid cultures, “skin-on-chip” technologies, reconstructed skin, bioprinting) considerably enhance physiological relevance, enabling a more accurate representation peculiar features. By reporting advantages limitations this highlights importance advanced systems develop practical anti-aging preventive reparative approaches improve translational field. Further exploration these technologies will provide new opportunities for previously unexplored knowledge

Language: Английский

3D Models Currently Proposed to Investigate Human Skin Aging and Explore Preventive and Reparative Approaches: A Descriptive Review DOI Creative Commons
Francesca Lombardi, Francesca Rosaria Augello, Alessia Ciafarone

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1066 - 1066

Published: Aug. 26, 2024

Skin aging is influenced by intrinsic and extrinsic factors that progressively impair skin functionality over time. Investigating the process requires thorough research using innovative technologies. This review explores use of in vitro human 3D culture models, serving as valuable alternatives to animal ones, research. The aim highlight benefits necessity improving methodology analyzing molecular mechanisms underlying aging. Traditional 2D including monolayers keratinocytes, fibroblasts, or melanocytes, even if providing cost-effective straightforward methods study critical processes such extracellular matrix degradation, pigmentation, effects secretome on cells, fail replicate complex tissue architecture with its intricated interactions. Advanced models (organoid cultures, “skin-on-chip” technologies, reconstructed skin, bioprinting) considerably enhance physiological relevance, enabling a more accurate representation peculiar features. By reporting advantages limitations this highlights importance advanced systems develop practical anti-aging preventive reparative approaches improve translational field. Further exploration these technologies will provide new opportunities for previously unexplored knowledge

Language: Английский

Citations

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