Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2848 - 2848
Published: Dec. 14, 2024
Background/Objectives:
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
characterized
by
the
accumulation
of
triglycerides
within
hepatocytes,
which
can
progress
to
more
severe
conditions,
such
as
metabolic
steatohepatitis
(MASH),
may
include
progressive
fibrosis,
leading
cirrhosis,
cancer,
and
death.
This
goal
this
review
highlight
recent
research
showing
potential
mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
in
reducing
key
pathogenic
pathways
MASLD
or
MASH.
Methods:
Relevant
published
studies
were
identified
using
PubMed
with
one
following
search
terms:
MASLD,
MASH,
NAFLD,
NASH,
exosome,
vesicle
(EV),
therapy,
and/or
cells
(MSC).
The
primary
literature
subsequently
downloaded
summarized.
Results:
Using
vitro
vivo
models,
MSC-EVs
have
been
found
counteract
oxidative
stress,
a
significant
contributor
injury
suppress
progression,
including
steatosis,
inflammation,
and,
few
instances,
fibrosis.
Some
these
outcomes
attributed
specific
EV
cargo
components
microRNAs
proteins.
Thus,
enriched
types
molecules
improved
therapeutic
efficacy
for
MASLD/MASH
represent
novel
approach
potentially
halt
reverse
process.
Conclusions:
are
attractive
agents
treating
MASLD/MASH.
Further
necessary
validate
clinical
applicability
human
MASH
patients,
focusing
on
optimizing
delivery
strategies
identifying
that
targeted
components.
Frontiers in Psychiatry,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 7, 2025
In
this
review,
it
is
evaluated
the
progress
in
application
of
stem
cell
therapy
to
ameliorate
symptoms
bipolar
disorder,
major
depression,
schizophrenia,
and
autism.
These
disorders
are
highly
prevalent
clinical
medicine
responsible
for
high
levels
psychosocial
disability
among
patients.
All
them
share
common
biomedical
features,
such
as
complex
variable
genetic
substrates,
significant
susceptibility
environmental
changes,
insufficient
knowledge
their
pathogenesis.
addition,
responsiveness
patients
pharmacological
treatment
heterogeneous,
some
cases,
no
available.
Therefore,
development
cell-based
regenerative
its
possible
combination
with
emerging
therapeutic
approaches
that
promote
neural
plasticity
expected
advance
neuropsychiatry
next
few
decades.
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 23, 2025
Interest
in
prostate
cancer
as
a
research
topic
has
gradually
increased.
As
result,
series
of
innovative
treatment
strategies
have
emerged
with
an
in-depth
understanding
the
disease.
Owing
to
their
unique
biological
characteristics,
mesenchymal
stromal
cell
exosomes
(MSC-Exos)
garnered
significant
attention
for
potential
deliver
targeted
drugs
and
enable
precise
treatment.
Herein,
MSC-Exos
drug-delivery
systems
is
reviewed.
This
review
provides
comprehensive
introduction
advantages
these
systems,
current
trends
progress,
well
analysis
challenges
future
directions.
Moreover,
this
lays
solid
foundation
continued
development
application
MSC-Exos.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Advanced
prostate
cancer
is
distinguished
by
substantial
heterogeneity
and
intricacy,
which
present
challenges
in
devising
effective
treatment
strategies.
The
genetic
landscape
of
frequently
altered,
contributing
to
the
development
resistance
conventional
therapies
exacerbating
systemic
toxicity.
These
necessitate
more
targeted
efficacious
therapeutic
modalities.
Mesenchymal
stem
cells
(MSCs)
have
been
demonstrated
possess
unique
properties
tumor-homing
potential.
MSC-derived
exosomes
reflect
molecular
composition
biological
capabilities
their
parent
cells.
nanovesicles
emerged
as
a
promising
platform
for
drug
delivery
systems
due
biocompatibility
inherent
ability
traffic
bioactive
molecules.
Modification
loading
them
with
agent
or
incorporating
surface
modifications
further
enhances
precision
therapy,
enabling
direct
while
minimizing
off-target
effects.
Herein,
we
review
effects
naïve
cancer.
Furthermore,
explore
cancer-specific
exosome
modifications,
emphasizing
cargo-loading
strategies,
particular
focus
on
emerging
roles
gene
sonodynamic
vaccine-based
therapeutics,
potential
clinical
applications.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 13
Published: April 10, 2025
This
review
aims
to
explore
the
research
progress
and
application
prospects
of
mesenchymal
stem
cells
(MSCs)
in
treatment
ischemic
cardiomyopathy
(ICM).
ICM
is
a
severe
heart
disease
characterized
by
death
myocardial
due
long-term
ischemia,
leading
impaired
function.
MSCs
have
become
one
promising
therapeutic
methods
for
treating
their
unique
anti-inflammatory,
anti-apoptotic,
immunomodulatory,
pro-angiogenic
properties.
Studies
shown
that
can
improve
function
promoting
neovascularization,
reducing
cell
apoptosis,
inhibiting
inflammatory
responses,
regulating
immune
reactions.
Additionally,
be
sourced
from
various
tissues,
including
bone
marrow,
adipose
tissue,
umbilical
cord/placenta,
with
different
sources
possessing
distinct
characteristics
effects.
Clinical
studies
indicated
MSC
therapy
physical
capacity
left
ventricular
ejection
fraction
(LVEF)
patients
intractable
angina,
enhance
perfusion
overall
infarction.
However,
issues
such
as
mechanisms
MSCs,
optimal
source,
infusion
routes,
dose
optimization
still
require
further
research.
Future
need
address
these
transform
clinical
trials
routine
practice,
thereby
revolutionizing
management
prognosis
ICM.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: April 24, 2025
ABSTRACT
Modern
advancements
in
medicine
include
developing
targeted
drug
delivery
systems
the
medical
field,
which
are
designed
to
unravel
potential
of
therapeutic
products
and
overcome
barriers
effectiveness
current
approaches.
Various
nanopolymer
carrier
have
been
introduced
this
regard,
simple
characteristics
extracellular
vesicles
drawn
special
attention
their
application
as
an
effective
tool.
Exosomes
very
similar
transport
a
lipid‐biomembrane
covering
aqueous
core.
They
also
contain
both
hydrophilic
lipophilic
substances
deliver
cargo
desired
targets.
These
properties
enable
exosomes
some
limitations
liposomes.
can
easily
diffuse
into
body
fluids
remain
bloodstream
for
long
time,
crossing
physiological
entering
cells.
Exosomes,
large
volume
biomolecules,
do
not
stimulate
immune
responses
accumulate
liver
or
lungs
instead
target
tissues.
Recent
regenerative
enabled
scientists
utilize
extracted
from
mesenchymal
stem
cells
(MSCs),
possess
significant
abilities,
treating
various
diseases.
The
contents
these
crucial
diagnosis
treatment,
they
influence
disease
progression.
Numerous
vitro
studies
confirmed
safety,
effectiveness,
promise
conditions
such
cancer,
neurodegenerative
disorders,
cardiovascular
issues,
orthopedic
ailments.
This
article
explores
MSC‐derived
outlines
essential
procedures
preparation.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1354 - 1354
Published: Oct. 24, 2024
Mesenchymal
stem
cells
(MSCs)
are
capable
of
differentiating
into
various
cell
types
and
play
a
crucial
role
in
repairing
aging
tissues
diseased
organs.
Aging
manifests
as
gradual
loss
cellular,
tissue,
organ
function,
leading
to
the
progression
pathologies.
Exosomes
(Exos)
extracellular
vesicles
secreted
by
cells,
which
maintain
cellular
homeostasis,
clear
debris,
facilitate
communication
between
This
review
provides
comprehensive
summary
mechanisms
for
synthesis
sorting
MSC-Exo
miRNAs
summarizes
current
research
status
MSCs-Exos
mitigating
age-related
diseases.
It
delves
underlying
molecular
mechanisms,
encompass
antioxidative
stress,
anti-inflammatory
response,
promotion
angiogenesis.
Additionally,
this
also
discusses
potential
challenges
future
strategies
advancing
miRNA-based
therapies
treatment
