The Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension DOI Open Access
Dmitri Atiakshin, A. A. Kostin,

А. В. Алехнович

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11010 - 11010

Published: Oct. 13, 2024

Molecular hydrogen (H2) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced hypertension (MPH), we had previously explored the impact of inhaled H2 on lung inflammation blood pressure. this study, further focused biological effects mast cells (MCs) parameters phenotype local tissue microenvironment. MPH resulted in significantly increased number MCs both pneumatic respiratory parts lungs, an tryptase-positive with expression TGF-β, activated interaction immunocompetent (macrophages plasma cells) fibroblasts, MC colocalization fibrous component extracellular matrix connective tissue. The alteration properties population occurred together intensified collagen fibrillogenesis increase integral volume elastic fibers exposure monocrotaline (MCT), despite individual differences between animals, tended to decrease intrapulmonary severity microenvironment compared animals exposed MCT effect alone. addition, activity associated TGF-β tryptase decreased, accompanied reduction absolute relative content reticular stroma. Thus, exposure, antifibrotic involving lungs rats. This reveals unknown development mechanisms remodeling features under inflammatory background conditions

Language: Английский

Signaling Paradigms of H2S-Induced Vasodilation: A Comprehensive Review DOI Creative Commons
Constantin Munteanu, Cristina Raluca Gh. Popescu, Andreea-Iulia Vlădulescu-Trandafir

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1158 - 1158

Published: Sept. 25, 2024

Hydrogen sulfide (H

Language: Английский

Citations

10
Theoretical evaluation of the biological activity of hydrogen DOI Creative Commons
G. Russell

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(2), P. 266 - 275

Published: Jan. 18, 2025

Hydrogen (H 2 ), the simplest and most ubiquitous molecule in universe, has garnered significant scientific interest over past two decades because of its potential as an effective antioxidant anti-inflammatory agent. Traditionally considered inert, H is now being re-evaluated for unique bioactive properties. selectively neutralizes reactive oxygen nitrogen species, mitigating oxidative stress without disrupting essential cellular functions. This review therefore aims to provide a theoretical evaluation biological activity , focusing on pharmacokinetics, including absorption, distribution, retention within systems. The pharmacokinetic profile crucial understanding therapeutic applications. interaction with protein pockets particular interest, these sites may serve reservoirs or active influencing time. Additionally, impact signaling pathways, those regulating glucose metabolism responses, will be explored, offering insights into modulator metabolic redox homeostasis. Finally, interactions ferromagnetic molecules environments, well effects mechanisms, add another layer complexity role . By synthesizing current research, this seeks elucidate underlying mechanisms by which exert while also identifying critical areas further investigation. Understanding aspects fully characterizing pharmacodynamic assessing clinical treatment stress–related disorders.

Language: Английский

Citations

0
Molecular mechanisms for pathophysiology and therapy of cardiac dysfunction in heart failure DOI Creative Commons
Naranjan S. Dhalla, Vijayan Elimban, Adriana Adameová

et al.

SCRIPTA MEDICA, Journal Year: 2025, Volume and Issue: 56(1), P. 117 - 136

Published: Jan. 1, 2025

Extensive work over the past 6 decades in field of cardiovascular medicine has revealed that haemodynamic, hormonal, metabolic, cellular and molecular mechanisms heart failure are not only complex but also dependent upon type stage disease. Although various agents such as b-adrenoreceptor blockers, angiotensin converting enzyme inhibitors, II receptor antagonists vasodilators available for treatment failure, these interventions delay progression without reducing mortality morbidity. In this article, literature on pathophysiology due to myocardial infarction haemodynamic overload identify targets future drug development is reviewed. Particularly, objective was focus involving pathways generation oxidative stress, inflammation Ca2+-handling abnormalities. It evident elevated levels plasma vasoactive hormones growth factors well increased preload afterload play critical roles stimulating signal transduction occurrence ventricular wall cardiac remodelling subsequent dysfunction. These alterations associated with inflammation, endothelial dysfunction, metabolic defects, intracellular abnormalities, apoptosis, fibrosis changes extracellular matrix. view pathogenic abnormalities failing hearts, it suggested parameters may serve excellent therapy failure. addition, there occurs activation proteases phospholipases depression gene expression induction subcellular hearts thus affecting be considered exert beneficial effects There an urgent need develop some existing newer antioxidants sodium-glucose cotransporter-2 inhibitors RNA based therapies

Language: Английский

Citations

0
Involvement of Oxidative Stress and Antioxidants in Modification of Cardiac Dysfunction Due to Ischemia–Reperfusion Injury DOI Creative Commons

Naranjan S. Dhalla,

Petr Ošťádal, Paramjit S. Tappia

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 340 - 340

Published: March 14, 2025

Delayed reperfusion of the ischemic heart (I/R) is known to impair recovery cardiac function and produce a wide variety myocardial defects, including ultrastructural damage, metabolic alterations, subcellular Ca2+-handling abnormalities, activation proteases, changes in gene expression. Although I/R injury has been reported induce formation reactive oxygen species (ROS), inflammation, intracellular Ca2+ overload, generation oxidative stress considered play critical role development dysfunction. Increases production superoxide, hydroxyl radicals, oxidants, such as hydrogen peroxide hypochlorous acid, occur hearts subjected injury. In fact, mitochondria are major source excessive ROS due impairment electron transport system well xanthine oxidase NADPH oxidase. Nitric oxide synthase, mainly present endothelium, also activated injury, leading nitric oxide, which, upon combination with superoxide generates nitrosative stress. Alterations function, sarcolemma, sarcoplasmic reticulum activities, mitochondrial phosphorylation, protease simulated exposing oxyradical-generating (xanthine plus oxidase) or H2O2. On other hand, endogenous antioxidants dismutase, catalase, glutathione peroxidase, concentration transcription factor (Nrf2), which modulates expression various antioxidants, depressed hearts. Furthermore, pretreatment catalase N-acetylcysteine, mercaptopropionylglycerine observed attenuate I/R-induced handling Ca2+-regulatory activities; additionally, it found depress improve function. These observations indicate that intimately involved pathological effects different alterations Thus, we faced task developing safe effective agents for upregulating therapy

Language: Английский

Citations

0
Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer DOI

Meena Sahu,

Utkarsh Jain

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(5), P. 167764 - 167764

Published: March 14, 2025

Language: Английский

Citations

0
Tree-inspired magnesium hybrid column for preventing hip collapse in steroid-associated osteonecrosis in bipedal emus DOI Creative Commons
Haiyue Zu, Lizhen Zheng, Mengke Huo

et al.

Materials Today, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

2
Synergistic Antioxidant Effects of Molecular Hydrogen and Cold Atmospheric Plasma in Enhancing Mesenchymal Stem Cell Therapy DOI Creative Commons
Mikhail Yu. Artamonov,

Felix A. Pyatakovich,

Inessa А. Minenko

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1584 - 1584

Published: Dec. 23, 2024

In regenerative medicine, mesenchymal stem cells (MSCs) have shown their importance and potential in tissue reconstruction immune system modification. However, such cells’ is often diminished by factors as oxidative stress, rejection, inadequate engraftment. This review highlights the role of molecular hydrogen (H2) cold atmospheric plasma (CAP) adjunct therapies to improve effectiveness MSC therapy. H2 has strong antioxidative anti-inflammatory actions it quenches reactive oxygen species positively stimulates Nrf2 pathway that promotes survival life. CAP, being a modulated source ROS RNS, also assists MSCs altering cellular redox balance, thus facilitating adaptation, migration, differentiation. CAP conjunction with each other assist establishing an ambience favorable for promoting MSCs’ growth abilities, reduce healing time various pathways wound, neuroprotection, ischemia. Besides these concerns, this covers best administration routes doses together study informs on novel dual method aimed at improving outcome therapy while adding several targets relevant clinical uses concerning therapies. Research future deal bettering protocols so therapeutic benefits can be maximized without long-term implications applications.

Language: Английский

Citations

1
The Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension DOI Open Access
Dmitri Atiakshin, A. A. Kostin,

А. В. Алехнович

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11010 - 11010

Published: Oct. 13, 2024

Molecular hydrogen (H2) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced hypertension (MPH), we had previously explored the impact of inhaled H2 on lung inflammation blood pressure. this study, further focused biological effects mast cells (MCs) parameters phenotype local tissue microenvironment. MPH resulted in significantly increased number MCs both pneumatic respiratory parts lungs, an tryptase-positive with expression TGF-β, activated interaction immunocompetent (macrophages plasma cells) fibroblasts, MC colocalization fibrous component extracellular matrix connective tissue. The alteration properties population occurred together intensified collagen fibrillogenesis increase integral volume elastic fibers exposure monocrotaline (MCT), despite individual differences between animals, tended to decrease intrapulmonary severity microenvironment compared animals exposed MCT effect alone. addition, activity associated TGF-β tryptase decreased, accompanied reduction absolute relative content reticular stroma. Thus, exposure, antifibrotic involving lungs rats. This reveals unknown development mechanisms remodeling features under inflammatory background conditions

Language: Английский

Citations

0