The Association Between Periodontal Inflamed Surface Area (PISA), Inflammatory Biomarkers, and Mitochondrial DNA Copy Number DOI Open Access

Romana Mance Kristan,

Staša Jurgec, Uroš Potočnik

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 24 - 24

Published: Dec. 25, 2024

Background/Objectives: Periodontitis is an inflammatory disease induced by bacteria in dental plaque that can activate the host’s immune-inflammatory response and invade bloodstream. We hypothesized a higher periodontal inflamed surface area (PISA) associated with levels of biomarkers, lower antioxidants, mitochondrial DNA copy number (mtDNAcn). Methods: Using parameters, we calculated PISA score, measured biomarkers antioxidants serum, took buccal swabs for mtDNA nuclear (nDNA) extraction. Results: Higher was CRP levels, leukocyte, neutrophil, erythrocyte counts, magnesium-to-calcium ratio, but not mtDNAcn. A deep pockets leukocytes neutrophil counts uric acid levels. Conclusions: The score might be appropriate parameter to assess burden periodontitis, dysfunction after isolation from swabs.

Language: Английский

The Association Between Periodontal Inflamed Surface Area (PISA), Inflammatory Biomarkers, and Mitochondrial DNA Copy Number DOI Open Access

Romana Mance Kristan,

Staša Jurgec, Uroš Potočnik

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 24 - 24

Published: Dec. 25, 2024

Background/Objectives: Periodontitis is an inflammatory disease induced by bacteria in dental plaque that can activate the host’s immune-inflammatory response and invade bloodstream. We hypothesized a higher periodontal inflamed surface area (PISA) associated with levels of biomarkers, lower antioxidants, mitochondrial DNA copy number (mtDNAcn). Methods: Using parameters, we calculated PISA score, measured biomarkers antioxidants serum, took buccal swabs for mtDNA nuclear (nDNA) extraction. Results: Higher was CRP levels, leukocyte, neutrophil, erythrocyte counts, magnesium-to-calcium ratio, but not mtDNAcn. A deep pockets leukocytes neutrophil counts uric acid levels. Conclusions: The score might be appropriate parameter to assess burden periodontitis, dysfunction after isolation from swabs.

Language: Английский

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