Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321078 - e0321078

Published: April 3, 2025

Objective To investigate whether time-restricted feeding (TRF) can reduce blood pressure (BP) and improve cardiac structure function in spontaneously hypertensive rats (SHRs) by regulating the renin-angiotensin system (RAS). Methods Wistar Kyoto SHR underwent 16 weeks of TRF intervention, with daily restricted to 9 am–5 pm. The effects on systolic BP, diastolic mean body weight (BW), heart (HW), HW/BW ratio, function, RAS activity circulating left ventricular (LV) tissues were investigated. Results effectively reduced BW; improved hypertension-induced structural functional damage; inhibited ACE-Ang-II-AT1 axis LV tissues. Conclusion inhibits both tissues, thereby lowering BP mitigating damage associated hypertension.

Language: Английский

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Special Issue: “New Trends in Diabetes, Hypertension, and Cardiovascular Diseases—2nd Edition”

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 449 - 449

Published: Jan. 7, 2025

Cardiovascular diseases (CVDs) encompass a range of conditions affecting both the heart (e.g., coronary disease and failure [1]) blood vessels cerebrovascular [2] peripheral artery [3]) [...].

Language: Английский

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SEMA6D modulates extracellular matrix metabolism in osteoarthritis by inhibiting the AGT/AGTR1a/IL‐1β axis

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(7)

Published: April 4, 2025

Abstract The tissue‐localized renin‐angiotensin system (tRAS) plays a pivotal role in the crosstalk between cardiovascular factors and osteoarthritis (OA). Semaphorin 6D (SEMA6D), neuroeffector, may contribute to chondrocyte homeostasis; however, its cartilage‐specific functions remain unclear. Chondrocytes with altered SEMA6D expression were established via gene transfection. RNA sequencing was performed identify SEMA6D‐related genes pathways, preliminary validation human OA samples. Furthermore, biochemical methods employed investigate of AGT/AGTR1a/IL‐1β axis mediating SEMA6D‐associated extracellular matrix metabolism (ECM). An AAV5‐based lentiviral vector used generate rat models overexpressing SEMA6D, followed by radiological histological analyses. overexpression significantly enhanced ECM homeostasis, marked increased Aggrecan, COL2A1 decreased COL10A1, MMP13, Runx2 expression. These SEMA6D‐induced enriched tRAS pathway, AGT, AGTR1a, IL‐1β identified as critical targets. activated degradation chondrocytes, while effectively suppressed this signaling. In model, elevated reduced cartilage degradation. confers chondroprotective effects modulating likely through inhibition axis, thereby regulating hypertrophy. findings enhance our understanding influences on health reveal tissue‐specific regulatory mechanisms OA.

Language: Английский

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Prognostic value of nomogram model based on clinical risk factors and CT radiohistological features in hypertensive intracerebral hemorrhage

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

To construct a nomogram model based on clinical risk factors and CT radiohistological features to predict the prognosis of hypertensive intracerebral hemorrhage (HICH).

Language: Английский

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