The Functional Interaction Between Epstein–Barr Virus and MYC in the Pathogenesis of Burkitt Lymphoma DOI Open Access

Sandra Solares,

Javier León, Lucía García-Gutiérrez

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4212 - 4212

Published: Dec. 18, 2024

The Epstein–Barr virus (EBV) is associated with a wide range of diseases, malignant and non-malignant. EBV was, in fact, the first described cell transformation capacity, discovered by Epstein 1964 lymphoma samples from African children. Since then, has been several human tumors including nasopharyngeal carcinoma, gastric T-cell lymphoma, Hodgkin diffuse large B Burkitt among others. molecular hallmark (BL) chromosomal translocation that involves MYC gene immunoglobulin loci, resulting deregulated expression MYC, an oncogenic transcription factor appears about half tumors. role well established, as overexpression drives proliferation through multiple mechanisms, foremost, stimulation cycle. Indeed, found overexpressed or non-Hodgkin lymphomas. Most endemic many sporadic BLs are infection. While some mechanisms which can contribute to BL have reported, mechanism links infection still under debate. Here, we review main EBV-associated special focus on BL, discuss interaction during BL.

Language: Английский

Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders DOI
Azhagu Madhavan Sivalingam

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 11, 2025

Language: Английский

Citations

0
Revealing the viral culprits: the hidden role of the oral virome in head and neck cancers DOI Creative Commons
Abdelhakim Salem

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(4)

Published: Feb. 28, 2025

Abstract The oral viral microbiome (or virome), encompassing a diverse community of viruses within the cavity, has emerged as significant yet underexplored factor in head and neck cancers (HNCs). This review synthesizes recent evidence linking virome to carcinogenesis, particularly oropharyngeal nasopharyngeal carcinomas—the most common virus-associated subtypes HNCs. Beyond pathogenesis, diagnostic therapeutic implications are explored, including non-invasive salivary detection biomarkers for early cancer diagnosis, development targeted antiviral therapies, preventive vaccination strategies—exemplified by success HPV vaccines reducing incidence cancers. Despite these advancements, challenges persist, technical limitations, need longitudinal studies, integration multi-omics approaches. A comprehensive understanding could revolutionize diagnostics, therapeutics, prevention. Moving forward, collaborative interdisciplinary efforts will be essential fully leverage research improving HNC outcomes.

Language: Английский

Citations

0
Metachronous Occurrence of Epstein-Barr Virus-Positive Mucocutaneous Ulcers Suspected to be Related to Periodontitis: A Case Report DOI
Yukiko Kusuyama,

Rie Irie,

Atsuko Niki-Yonekawa

et al.

Journal of Oral and Maxillofacial Surgery Medicine and Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Reactivation of Latent Tuberculosis Following COVID-19 and Epstein-Barr Virus Coinfection: A Case Report DOI Creative Commons
Iryna Halabitska, Pavlo Petakh, Valentyn Oksenych

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(5), P. 488 - 488

Published: May 16, 2025

Background: This case is unique in demonstrating the reactivation of latent tuberculosis (TB) following co-infection with SARS-CoV-2 and Epstein–Barr virus (EBV) an otherwise healthy young adult. It highlights a rare clinical scenario which viral immune dysregulation likely facilitated TB progression. To date, few reports have explored complex interplay between COVID-19, EBV reactivation, single patient, particularly isolated extrapulmonary involvement. Case Presentation: A 24-year-old woman presented persistent low-grade fever, fatigue, night sweats, unintentional weight loss, progressive cervical supraclavicular lymphadenopathy. These symptoms emerged shortly after moderate COVID-19 infection. Laboratory studies revealed elevated inflammatory markers pronounced lymphopenia. was confirmed via serology PCR. Despite antiviral therapy, persisted, imaging necrotic Tuberculous lymphadenitis diagnosed through fine-needle aspiration cytology PCR detection Mycobacterium tuberculosis. The patient treated standard anti-tuberculosis regimen, resulting clinical, radiological, immunological improvement. Conclusions: underscores importance considering patients lymphadenopathy recent infections, regions high prevalence. also emphasizes need for thorough microbiological assessment post-viral syndromes. main takeaway that may create permissive environment system compromise.

Language: Английский

Citations

0
Insights into the complexities of Citrullination: From immune regulation to autoimmune disease DOI
Jiawei Wang,

Jinlin Miao,

Ping Zhu

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 103734 - 103734

Published: Dec. 1, 2024

Language: Английский

Citations

1
The Functional Interaction Between Epstein–Barr Virus and MYC in the Pathogenesis of Burkitt Lymphoma DOI Open Access

Sandra Solares,

Javier León, Lucía García-Gutiérrez

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4212 - 4212

Published: Dec. 18, 2024

The Epstein–Barr virus (EBV) is associated with a wide range of diseases, malignant and non-malignant. EBV was, in fact, the first described cell transformation capacity, discovered by Epstein 1964 lymphoma samples from African children. Since then, has been several human tumors including nasopharyngeal carcinoma, gastric T-cell lymphoma, Hodgkin diffuse large B Burkitt among others. molecular hallmark (BL) chromosomal translocation that involves MYC gene immunoglobulin loci, resulting deregulated expression MYC, an oncogenic transcription factor appears about half tumors. role well established, as overexpression drives proliferation through multiple mechanisms, foremost, stimulation cycle. Indeed, found overexpressed or non-Hodgkin lymphomas. Most endemic many sporadic BLs are infection. While some mechanisms which can contribute to BL have reported, mechanism links infection still under debate. Here, we review main EBV-associated special focus on BL, discuss interaction during BL.

Language: Английский

Citations

0