REDD1-dependent GSK3β signaling in podocytes promotes canonical NF-κB activation in diabetic nephropathy

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108244 - 108244

Published: Jan. 1, 2025

Language: Английский

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Lipopolysaccharide-Induced Inflammatory Response and Its Prominent Suppression by Paspalum thunbergii Extract

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1611 - 1611

Published: Feb. 13, 2025

The extract of Paspalum thunbergii, a native perennial herb in Korea belonging to the rice family, was investigated for its anti-inflammatory activity and underlying mechanisms driving effects. Fifteen chemical components P. thunbergii extract, including rosmarinic acid isoquercitrin, were identified using LC-MS. showed antioxidative through DPPH ABTS cation radical scavenging activity. significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production macrophage RAW 264.7 cells. expression lipopolysaccharide-induced iNOS COX-2, which are inflammation-related enzymes. To explore mechanism, levels signal proteins related MAPK, NF-κB, JAK/STAT, Wnt/β-catenin signaling measured. As result, p-p38, p-JNK increased by LPS Additionally, it decreased LPS-induced p-IKKβ p-NF-κB p65 prevented migration into nucleus caused LPS. Notably, p-JAK1, p-STAT3, Wnt 3α, β-catenin, p-GSK-3β protein expressions also inhibited. Therefore, prominent may be via pathway.

Language: Английский

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GSK-3β dysregulation in aging: Implications for tau pathology and Alzheimer's disease progression

Molecular and Cellular Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 104005 - 104005

Published: March 1, 2025

Language: Английский

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Neuroprotective Effect of Perillyl alcohol in Sporadic Alzheimer’s disease in Rats

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177558 - 177558

Published: April 1, 2025

Language: Английский

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