Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 1, 2025

Photodynamic therapy (PDT) holds considerable promise as a tumor treatment modality, characterized by its targeted action, compatibility with other therapeutic approaches, and non - invasive features. PDT can achieve remarkable spatiotemporal precision in ablation through the generation of reactive oxygen species (ROS). Nevertheless, despite potential treatment, encounters multiple challenges practical applications. is highly dependent, thus effectiveness be markedly influenced hypoxia. The co-existence abnormal vasculature metabolic deregulation gives rise to hypoxic microenvironment, which not only sustains survival but also undermines efficacy PDT. Consequently, targeting angiogenesis metabolism essential for revitalizing This review emphasizes mechanisms strategies predominantly concentrating on interfering reprogramming cell metabolism. Lastly, outlining future perspectives current limitations are summarized. could provide new insights methodologies overcoming associated ultimately advancing field

Language: Английский