Journal of Biochemicals and Phytomedicine,
Journal Year:
2024,
Volume and Issue:
3(2), P. 1 - 3
Published: Dec. 31, 2024
This
editorial
highlights
the
critical
significance
of
integrating
traditional
and
modern
methodologies
in
drug
discovery,
emphasizing
role
herbal
substances
phytomedicines
advancing
global
health
scientific
progress.
By
examining
latest
research
innovations,
it
underscores
how
fusion
plant-based
therapies
with
contemporary
techniques
can
enhance
therapeutic
efficacy
determine
novel
approaches
for
treatment
various
ailments.
comprehensive
approach
offers
unique
opportunities
to
develop
effective
sustainable
therapies,
thereby
pharmaceutical
science
improving
outcomes.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
AbstractDatura
metel
L.,
a
plant
belonging
to
the
solanaceae
family,
is
renowned
for
its
medicinal,
agrochemical
and
poisonous
properties.
This
research
assessed
chemical
makeup,
antioxidant
properties,
phytochemical
content
of
D.
metel
leaf
extracts
by
employing
different
solvents:
ethanol
(EtOH),
ethyl
acetate
(EA),
dichloromethane
(DCM),
n-hexane
(n-Hx),
distilled
water
(DW).
Chemical
profile
was
Gas
Chromatography-Mass
Spectrometry
(GC-MS)
assay
whereas;
activity
determined
using
1,
1-diphenyl-2-picrylhydrazyl
(DPPH)
assay.
While,
Insecticidal
against
Brevicoryne
brassicae
evaluated
via
aphid
dip
method.
On
other
hand,
quantitative
qualitative
analysis
carried
out
Folin–Ciocalteu
reagent
method
aluminum
chloride
colorimetric
method,
respectively.
GC-MS
identified
four
major
compounds
as:
11H-Pyrido
[3’,2’:4,5]
imidazo
[2,1-b]
[1,3]
benzothiazin-11-one
(29.76%),
1,3-dimethyl
Benzene
(18.35%),
Didodecyl
phthalate
(11.73%),
1,3,5-Trimethylbenzene
(10.09%),
along
with
six
minor
compounds.
Qualitative
extract
discovered
alkaloids,
flavonoids,
phenols,
glycosides,
substances.
Whereas,
tests
revealed
high
concentration
phenols
(75.03
GAEg−
1)
in
increased
levels
flavonoids
(99.33
QEg−
1).
All
samples
showed
significant
DPPH
inhibition
ranging
from
63.91–81.59%.
Similarly,
displayed
mortality
81.66%
73.33%
at
48
h
exposure
200
mgmL−
1
assay,
These
findings
underline
potential
utilizing
leaves
as
valuable
source
bioactive
medicinal
advantages.
