Burden of colorectal cancer attributable to high body-mass index in 204 countries and territories, 1990–2021: Results from the Global Burden of Disease Study 2021

Public Health, Journal Year: 2025, Volume and Issue: 242, P. 388 - 398

Published: April 8, 2025

Language: Английский

Clinical Significance of Blood Cell-Derived Inflammation Markers in Assessing Potential Early and Late Postoperative Complications in Patients with Colorectal Cancer: A Systematic Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2529 - 2529

Published: April 7, 2025

Background/Objectives: Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Despite advancements in surgical techniques and oncological treatments, postoperative complications remain a significant challenge, affecting both immediate recovery long-term survival. Systemic inflammation has been identified as critical factor influencing progression outcomes. This systematic review evaluates clinical significance blood cell-derived inflammatory markers predicting early late CRC patients. Methods: We included studies involving adult patients (≥18 years) with histologically confirmed colorectal cancer, for whom elective radical surgery was performed, well at least considered blood-based biomarkers (NLR, PLR, SII, or LMR) documented relation to Results: After removing duplicates, 19 published between 2016 2025 were qualitative analysis. A total 7023 who underwent curative analyzed, mean age varying widely 47.3 74.6 years. Preoperative NLR values significantly correlated severe complications, IAI, AL, overall 13 out (68.4%), cutoff value 2.21 4, while predictive AL. Late such recurrence survival, also associated elevated preoperative PLR values. However, variability study designs, patient populations, these indices contributed inconsistent findings. Conclusions: Blood offer valuable, non-invasive tool assessing risks CRC. New design nomograms risk scores that include, beside markers, other relevant data, could ensure an optimal be easily used practice personalized management cancer.

Language: Английский

Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(11)

Published: Nov. 15, 2024

Colorectal cancer (CRC) exhibits a substantial morbidity and mortality rate, with its aetiology pathogenesis remain elusive. It holds significant importance within the tumour microenvironment (TME) exerts crucial regulatory influence on tumorigenesis, progression, metastasis. TAMs possess capability to foster CRC pathogenesis, proliferation, invasion, metastasis, as well angiogenesis, immune evasion, resistance. Furthermore, can mediate prognosis of CRC. In this paper, we review mechanisms by which natural compounds target exert anti-CRC effects from perspective promotional CRC, mainly regulating polarization TAMs, reducing infiltration recruitment enhancing phagocytosis macrophages, signalling pathways cytokines, discuss potential value therapeutic strategies compounds-targeting pathway in clinical treatment.

Language: Английский