Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review DOI Creative Commons
Weichen Yuan,

Jiexiang Zhang,

Haibin Chen

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(11)

Published: Nov. 15, 2024

Colorectal cancer (CRC) exhibits a substantial morbidity and mortality rate, with its aetiology pathogenesis remain elusive. It holds significant importance within the tumour microenvironment (TME) exerts crucial regulatory influence on tumorigenesis, progression, metastasis. TAMs possess capability to foster CRC pathogenesis, proliferation, invasion, metastasis, as well angiogenesis, immune evasion, resistance. Furthermore, can mediate prognosis of CRC. In this paper, we review mechanisms by which natural compounds target exert anti-CRC effects from perspective promotional CRC, mainly regulating polarization TAMs, reducing infiltration recruitment enhancing phagocytosis macrophages, signalling pathways cytokines, discuss potential value therapeutic strategies compounds-targeting pathway in clinical treatment.

Language: Английский

Clinical Significance of Blood Cell-Derived Inflammation Markers in Assessing Potential Early and Late Postoperative Complications in Patients with Colorectal Cancer: A Systematic Review DOI Open Access
И В Шевченко, Dragoș Șerban, Laurenţiu Simion

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2529 - 2529

Published: April 7, 2025

Background/Objectives: Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Despite advancements in surgical techniques and oncological treatments, postoperative complications remain a significant challenge, affecting both immediate recovery long-term survival. Systemic inflammation has been identified as critical factor influencing progression outcomes. This systematic review evaluates clinical significance blood cell-derived inflammatory markers predicting early late CRC patients. Methods: We included studies involving adult patients (≥18 years) with histologically confirmed colorectal cancer, for whom elective radical surgery was performed, well at least considered blood-based biomarkers (NLR, PLR, SII, or LMR) documented relation to Results: After removing duplicates, 19 published between 2016 2025 were qualitative analysis. A total 7023 who underwent curative analyzed, mean age varying widely 47.3 74.6 years. Preoperative NLR values significantly correlated severe complications, IAI, AL, overall 13 out (68.4%), cutoff value 2.21 4, while predictive AL. Late such recurrence survival, also associated elevated preoperative PLR values. However, variability study designs, patient populations, these indices contributed inconsistent findings. Conclusions: Blood offer valuable, non-invasive tool assessing risks CRC. New design nomograms risk scores that include, beside markers, other relevant data, could ensure an optimal be easily used practice personalized management cancer.

Language: Английский

Citations

1
Recent advances in the development and application of colorectal cancer mouse models DOI Creative Commons
Ting Wang, Zhen Chen, Yuli Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Colorectal cancer (CRC) remains a significant global health challenge, necessitating the development of reliable preclinical models to advance mechanistic understanding and therapeutic innovation. This review comprehensively examines diverse spectrum rodent employed in CRC research, focusing on their unique characteristics, applications, translational relevance. We systematically evaluate conventional models, including carcinogen-induced genetically engineered mouse (GEMMs), which have been instrumental elucidating tumorigenic pathways genetic drivers. Furthermore, we highlight emergence patient-derived xenografts (PDX) as transformative tool for recapitulating tumor heterogeneity predicting clinical responses. The also explores metastatic are critical studying advanced disease, spontaneous that mimic natural progression. Additionally, discuss growing utility composite animal integrate multiple methodologies better reflect complexity human CRC. By comparing strengths limitations each model system, this provides framework selecting appropriate based specific research objectives. Collectively, these platforms significantly our biology continue drive targeted therapies personalized treatment strategies.

Language: Английский

Citations

0
The Impact and Molecular Mechanisms of Exercise in Cancer Therapy DOI Creative Commons

Yingjie Sun,

Yixiao Ma, Lei Shi

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 374 - 374

Published: May 20, 2025

Cancer is a major global health issue, and exercise has become key supportive treatment. It contributes to reducing cancer risk, enhancing prognosis, aiding recovery, especially for survivors. However, the exact mechanisms, such as how reduces risk or enhances treatment, are still unclear. Current research often focuses on specific types, ignoring diverse needs of patients. This limits development personalized plans. Additionally, there insufficient comparison types—like aerobic, resistance, high-intensity interval training—regarding their adverse effects long-term benefits. The best combination exercises strategies remains unknown. review underscores contribution physical prevention emphasizing its positive fatigue, improving strength, mental health. also explores molecular mechanisms regulating tumor immunity energy metabolism. article covers criteria selecting types intensities, Finally, it provides guidelines prescriptions suggests future directions improve interventions

Language: Английский

Citations

0
Burden of colorectal cancer attributable to high body-mass index in 204 countries and territories, 1990–2021: Results from the Global Burden of Disease Study 2021 DOI
Qiuxia Zhang, Jia Feng, Zhijie Xu

et al.

Public Health, Journal Year: 2025, Volume and Issue: 242, P. 388 - 398

Published: April 8, 2025

Language: Английский

Citations

0
Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review DOI Creative Commons
Weichen Yuan,

Jiexiang Zhang,

Haibin Chen

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(11)

Published: Nov. 15, 2024

Colorectal cancer (CRC) exhibits a substantial morbidity and mortality rate, with its aetiology pathogenesis remain elusive. It holds significant importance within the tumour microenvironment (TME) exerts crucial regulatory influence on tumorigenesis, progression, metastasis. TAMs possess capability to foster CRC pathogenesis, proliferation, invasion, metastasis, as well angiogenesis, immune evasion, resistance. Furthermore, can mediate prognosis of CRC. In this paper, we review mechanisms by which natural compounds target exert anti-CRC effects from perspective promotional CRC, mainly regulating polarization TAMs, reducing infiltration recruitment enhancing phagocytosis macrophages, signalling pathways cytokines, discuss potential value therapeutic strategies compounds-targeting pathway in clinical treatment.

Language: Английский

Citations

1