Expression and Targeted Application of Claudins Family in Hepatobiliary and Pancreatic Diseases DOI Creative Commons

Fangqian Du,

Yuwei Xie,

Shengze Wu

et al.

Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 1801 - 1821

Published: Sept. 1, 2024

Hepatobiliary and pancreatic diseases are becoming increasingly common worldwide associated cancers prone to recurrence metastasis. For a more accurate treatment, new therapeutic strategies urgently needed. The claudins (CLDN) family comprises class of membrane proteins that the main components tight junctions, essential for forming intercellular barriers maintaining cellular polarity. In mammals, claudin contains at least 27 transmembrane plays major role in mediating cell adhesion paracellular permeability. Multiple altered various cancers, including gastric cancer (GC), esophageal (EC), hepatocellular carcinoma (HCC), (PC), colorectal (CRC) breast (BC). An increasing number studies have shown closely with occurrence development hepatobiliary diseases. Interestingly, exhibit different effects on progression tumor tissues, suppression promotion. addition, currently being studied as potential diagnostic targets, claudin-3, claudin-4, claudin-18.2, etc. this article, functional phenotype, molecular mechanism, targeted application reviewed, an emphasis claudin-1, claudin-7 current situation future prospects proposed.

Language: Английский

LncRNA LINC01128 promotes prostate cancer cell proliferation, metastasis, and epithelial-mesenchymal transition by modulating miR-27b-3p DOI Creative Commons
Yuhui Zhao, Zhigang Zhang, Yi Zheng

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(3)

Published: March 4, 2025

Language: Английский

Citations

1
Current Insights on Salivary Gland Adenoid Cystic Carcinoma: Related Genes and Molecular Pathways DOI Open Access
Vasileios Zisis,

Konstantinos Poulopoulos,

Nikolaos Shinas

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 370 - 370

Published: March 24, 2025

Background/Objectives: Salivary adenoid cystic carcinoma (ACC) is a rare but aggressive neoplasm that predominantly arises from the salivary glands, accounting for significant proportion of gland cancers. The aim this literature review to illustrate current insights on ACC with regards related genes and molecular pathways by analyzing original research articles period 2015–2025. Methods: An electronic search was performed between January February 2025 identify all investigating its pathways. conducted using MEDLINE (National Library Medicine)-PubMed restrictions concerning date publication. In particular, we focused 2015–2025 following keywords: AND This followed manual search, references were used relevant articles. Results: total, 41 identified through keywords. After implementation time frame 2015–2025, 31 remained. Subsequently, reading titles abstracts thereby excluding non-original written in language other than English, 23 Conclusions: These studies or whose analysis yielded most recent data regarding their function. classification multifaceted, encompassing distinct histological subtypes are crucial determining prognosis treatment approaches. Current oncological practices classify based these features alongside emerging genetic markers promise enhance our understanding disease’s biology. Diagnostic strategies have evolved, leveraging techniques such as biopsy diagnostics, which significantly improved detection characterization ACC. Regarding treatment, management remains challenge due propensity local invasion metastasis, surgery, radiation, chemotherapy being mainstays therapy. development targeted therapies ACC’s profile will allow better an enhanced quality life patients.

Language: Английский

Citations

0
Polyphenols: Potential Applications in Cancer Therapy DOI Open Access
María Oriol‐Caballo, Paz Moreno-Murciano, Rafael López‐Blanch

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Polyphenols (PFs) are compounds found in fruits and vegetables, known for their health-related benefits, mainly including antioxidant, antiinflammatory, anticancer properties. However, efficacy is limited by poor bioavailability due to issues like low solubility, rapid metabolism, extensive excretion. Thus, research has focused on improving delivery systems, such as, example, nanoparticles, hydrogels, cocrystals, or conjugation with carrier molecules, which may protect PFs from degradation, improve and/or facilitate targeted cancer cells. promising modulating cancer-related pathways cell proliferation death, metastatic invasion, though translation patients hindered complex mechanisms. This review analyzes factors that affect PF bioavailability, evidences of vivo effects animal models mechanisms, results clinical trials, strategies enhance bioavailability. The idea need directly interact the challenged. Future aims optimize combine standard treatments, explore epigenetic effects, modulation tumor microenvironment, interactions gut microbiota. Advances personalized medicine structural modifications stability absorption could further potential. Despite challenges, remain a avenue complementary oncotherapy solutions.

Language: Английский

Citations

0
Unveiling the potency of ZnO and CuO nanocomposites in combating hepatocellular carcinoma by inducing cell death and suppressing migration DOI Creative Commons
Rasha Mahmoud Allam,

Nesma M. E. Abo El-Nasr,

Marawan A. Elbaset

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 3, 2025

Abstract Human hepatocellular carcinoma (HCC) is recognized as one of the leading causes death globally and resistant to several anticancer drugs. As a result, it critical identify more effective druggable therapies. Metal oxide nanoparticles (MO-NPs), especially nanocomposites, have recently received much attention owing their potential applications in cancer therapy. In this study, we synthesized zinc (ZnO) copper (CuO) nanocomposites different ratios (N1, N2, N3). We evaluated cytotoxicity against two HCC cell lines (HepG2 HuH-7) normal liver (BNL), compared with Sorafenib standard Then, investigated underlying mechanisms action employing flow cytometry, migration assay, western blot. The results showed that nanocomposite an equal ratio both ZnO CuO-NPs (N1) exhibited highest cytotoxic activity on HuH7 line while exerting no detrimental impact rat epithelial cells. Further investigation into toxicity N1 revealed three modalities induced (apoptotic, necrotic, autophagic) along S- G2/M cycle arrest, suggesting mitotic catastrophe. Furthermore, displayed potent anti-migratory activity, surpassing sorafenib, upregulated protein level autophagy marker beclin-1, downregulated EMT-marker vimentin. Overall, our findings combining ZnO-NPs intriguing combating HCC, providing prospective guidance for evolving therapy bimetallic NPs.

Language: Английский

Citations

0
The Molecular Basis of Pediatric Brain Tumors: A Review with Clinical Implications DOI Open Access
Elias Antoniades, Nikolaos Keffes, Stamatia C. Vorri

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1566 - 1566

Published: May 4, 2025

Central nervous system (CNS) tumors are the most common solid malignancy in pediatric population. These lesions result of aberrant cell signaling step proteins, which normally regulate proliferation. Mitogen-activated protein kinase (MAPK) pathways and tyrosine receptors involved tumorigenesis low-grade gliomas. High-grade gliomas may carry similar mutations, but loss epigenetic control is dominant molecular event; it can occur either due to histone mutations or inappropriate binding unbinding DNA on histones. Therefore, despite absence genetic alteration classic oncogenes tumor suppressor genes, uncontrolled transcription results tumorigenesis. Isocitric dehydrogenase (IDH) do not predominate compared their adult counterpart. Embryonic include medulloblastomas, bear transcription-regulating pathways, such as wingless-related integration sites sonic hedgehog pathways. They also relate high expression Myc family genes. Atypical teratoid rhabdoid harbor alterations molecules that contribute ATP hydrolysis chromatin. with multilayered rosettes associated microRNA impaired translation. Ependymomas exhibit great variability. As far supratentorial concerned, major events NFkB Hippo Posterior fossa further divided into two types different prognoses. Type A group damage repair molecules. Lastly, germ a heterogeneous group. Among them, germinomas manifest KIT receptor subgroup family.

Language: Английский

Citations

0
Expression and Targeted Application of Claudins Family in Hepatobiliary and Pancreatic Diseases DOI Creative Commons

Fangqian Du,

Yuwei Xie,

Shengze Wu

et al.

Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 1801 - 1821

Published: Sept. 1, 2024

Hepatobiliary and pancreatic diseases are becoming increasingly common worldwide associated cancers prone to recurrence metastasis. For a more accurate treatment, new therapeutic strategies urgently needed. The claudins (CLDN) family comprises class of membrane proteins that the main components tight junctions, essential for forming intercellular barriers maintaining cellular polarity. In mammals, claudin contains at least 27 transmembrane plays major role in mediating cell adhesion paracellular permeability. Multiple altered various cancers, including gastric cancer (GC), esophageal (EC), hepatocellular carcinoma (HCC), (PC), colorectal (CRC) breast (BC). An increasing number studies have shown closely with occurrence development hepatobiliary diseases. Interestingly, exhibit different effects on progression tumor tissues, suppression promotion. addition, currently being studied as potential diagnostic targets, claudin-3, claudin-4, claudin-18.2, etc. this article, functional phenotype, molecular mechanism, targeted application reviewed, an emphasis claudin-1, claudin-7 current situation future prospects proposed.

Language: Английский

Citations

0