LncRNA LINC01128 promotes prostate cancer cell proliferation, metastasis, and epithelial-mesenchymal transition by modulating miR-27b-3p
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2025,
Volume and Issue:
151(3)
Published: March 4, 2025
Language: Английский
Current Insights on Salivary Gland Adenoid Cystic Carcinoma: Related Genes and Molecular Pathways
Vasileios Zisis,
No information about this author
Konstantinos Poulopoulos,
No information about this author
Nikolaos Shinas
No information about this author
et al.
Genes,
Journal Year:
2025,
Volume and Issue:
16(4), P. 370 - 370
Published: March 24, 2025
Background/Objectives:
Salivary
adenoid
cystic
carcinoma
(ACC)
is
a
rare
but
aggressive
neoplasm
that
predominantly
arises
from
the
salivary
glands,
accounting
for
significant
proportion
of
gland
cancers.
The
aim
this
literature
review
to
illustrate
current
insights
on
ACC
with
regards
related
genes
and
molecular
pathways
by
analyzing
original
research
articles
period
2015–2025.
Methods:
An
electronic
search
was
performed
between
January
February
2025
identify
all
investigating
its
pathways.
conducted
using
MEDLINE
(National
Library
Medicine)-PubMed
restrictions
concerning
date
publication.
In
particular,
we
focused
2015–2025
following
keywords:
AND
This
followed
manual
search,
references
were
used
relevant
articles.
Results:
total,
41
identified
through
keywords.
After
implementation
time
frame
2015–2025,
31
remained.
Subsequently,
reading
titles
abstracts
thereby
excluding
non-original
written
in
language
other
than
English,
23
Conclusions:
These
studies
or
whose
analysis
yielded
most
recent
data
regarding
their
function.
classification
multifaceted,
encompassing
distinct
histological
subtypes
are
crucial
determining
prognosis
treatment
approaches.
Current
oncological
practices
classify
based
these
features
alongside
emerging
genetic
markers
promise
enhance
our
understanding
disease’s
biology.
Diagnostic
strategies
have
evolved,
leveraging
techniques
such
as
biopsy
diagnostics,
which
significantly
improved
detection
characterization
ACC.
Regarding
treatment,
management
remains
challenge
due
propensity
local
invasion
metastasis,
surgery,
radiation,
chemotherapy
being
mainstays
therapy.
development
targeted
therapies
ACC’s
profile
will
allow
better
an
enhanced
quality
life
patients.
Language: Английский
Polyphenols: Potential Applications in Cancer Therapy
Molecular Nutrition & Food Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Polyphenols
(PFs)
are
compounds
found
in
fruits
and
vegetables,
known
for
their
health-related
benefits,
mainly
including
antioxidant,
antiinflammatory,
anticancer
properties.
However,
efficacy
is
limited
by
poor
bioavailability
due
to
issues
like
low
solubility,
rapid
metabolism,
extensive
excretion.
Thus,
research
has
focused
on
improving
delivery
systems,
such
as,
example,
nanoparticles,
hydrogels,
cocrystals,
or
conjugation
with
carrier
molecules,
which
may
protect
PFs
from
degradation,
improve
and/or
facilitate
targeted
cancer
cells.
promising
modulating
cancer-related
pathways
cell
proliferation
death,
metastatic
invasion,
though
translation
patients
hindered
complex
mechanisms.
This
review
analyzes
factors
that
affect
PF
bioavailability,
evidences
of
vivo
effects
animal
models
mechanisms,
results
clinical
trials,
strategies
enhance
bioavailability.
The
idea
need
directly
interact
the
challenged.
Future
aims
optimize
combine
standard
treatments,
explore
epigenetic
effects,
modulation
tumor
microenvironment,
interactions
gut
microbiota.
Advances
personalized
medicine
structural
modifications
stability
absorption
could
further
potential.
Despite
challenges,
remain
a
avenue
complementary
oncotherapy
solutions.
Language: Английский
Unveiling the potency of ZnO and CuO nanocomposites in combating hepatocellular carcinoma by inducing cell death and suppressing migration
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 3, 2025
Abstract
Human
hepatocellular
carcinoma
(HCC)
is
recognized
as
one
of
the
leading
causes
death
globally
and
resistant
to
several
anticancer
drugs.
As
a
result,
it
critical
identify
more
effective
druggable
therapies.
Metal
oxide
nanoparticles
(MO-NPs),
especially
nanocomposites,
have
recently
received
much
attention
owing
their
potential
applications
in
cancer
therapy.
In
this
study,
we
synthesized
zinc
(ZnO)
copper
(CuO)
nanocomposites
different
ratios
(N1,
N2,
N3).
We
evaluated
cytotoxicity
against
two
HCC
cell
lines
(HepG2
HuH-7)
normal
liver
(BNL),
compared
with
Sorafenib
standard
Then,
investigated
underlying
mechanisms
action
employing
flow
cytometry,
migration
assay,
western
blot.
The
results
showed
that
nanocomposite
an
equal
ratio
both
ZnO
CuO-NPs
(N1)
exhibited
highest
cytotoxic
activity
on
HuH7
line
while
exerting
no
detrimental
impact
rat
epithelial
cells.
Further
investigation
into
toxicity
N1
revealed
three
modalities
induced
(apoptotic,
necrotic,
autophagic)
along
S-
G2/M
cycle
arrest,
suggesting
mitotic
catastrophe.
Furthermore,
displayed
potent
anti-migratory
activity,
surpassing
sorafenib,
upregulated
protein
level
autophagy
marker
beclin-1,
downregulated
EMT-marker
vimentin.
Overall,
our
findings
combining
ZnO-NPs
intriguing
combating
HCC,
providing
prospective
guidance
for
evolving
therapy
bimetallic
NPs.
Language: Английский
The Molecular Basis of Pediatric Brain Tumors: A Review with Clinical Implications
Cancers,
Journal Year:
2025,
Volume and Issue:
17(9), P. 1566 - 1566
Published: May 4, 2025
Central
nervous
system
(CNS)
tumors
are
the
most
common
solid
malignancy
in
pediatric
population.
These
lesions
result
of
aberrant
cell
signaling
step
proteins,
which
normally
regulate
proliferation.
Mitogen-activated
protein
kinase
(MAPK)
pathways
and
tyrosine
receptors
involved
tumorigenesis
low-grade
gliomas.
High-grade
gliomas
may
carry
similar
mutations,
but
loss
epigenetic
control
is
dominant
molecular
event;
it
can
occur
either
due
to
histone
mutations
or
inappropriate
binding
unbinding
DNA
on
histones.
Therefore,
despite
absence
genetic
alteration
classic
oncogenes
tumor
suppressor
genes,
uncontrolled
transcription
results
tumorigenesis.
Isocitric
dehydrogenase
(IDH)
do
not
predominate
compared
their
adult
counterpart.
Embryonic
include
medulloblastomas,
bear
transcription-regulating
pathways,
such
as
wingless-related
integration
sites
sonic
hedgehog
pathways.
They
also
relate
high
expression
Myc
family
genes.
Atypical
teratoid
rhabdoid
harbor
alterations
molecules
that
contribute
ATP
hydrolysis
chromatin.
with
multilayered
rosettes
associated
microRNA
impaired
translation.
Ependymomas
exhibit
great
variability.
As
far
supratentorial
concerned,
major
events
NFkB
Hippo
Posterior
fossa
further
divided
into
two
types
different
prognoses.
Type
A
group
damage
repair
molecules.
Lastly,
germ
a
heterogeneous
group.
Among
them,
germinomas
manifest
KIT
receptor
subgroup
family.
Language: Английский
Expression and Targeted Application of Claudins Family in Hepatobiliary and Pancreatic Diseases
Fangqian Du,
No information about this author
Yuwei Xie,
No information about this author
Shengze Wu
No information about this author
et al.
Journal of Hepatocellular Carcinoma,
Journal Year:
2024,
Volume and Issue:
Volume 11, P. 1801 - 1821
Published: Sept. 1, 2024
Hepatobiliary
and
pancreatic
diseases
are
becoming
increasingly
common
worldwide
associated
cancers
prone
to
recurrence
metastasis.
For
a
more
accurate
treatment,
new
therapeutic
strategies
urgently
needed.
The
claudins
(CLDN)
family
comprises
class
of
membrane
proteins
that
the
main
components
tight
junctions,
essential
for
forming
intercellular
barriers
maintaining
cellular
polarity.
In
mammals,
claudin
contains
at
least
27
transmembrane
plays
major
role
in
mediating
cell
adhesion
paracellular
permeability.
Multiple
altered
various
cancers,
including
gastric
cancer
(GC),
esophageal
(EC),
hepatocellular
carcinoma
(HCC),
(PC),
colorectal
(CRC)
breast
(BC).
An
increasing
number
studies
have
shown
closely
with
occurrence
development
hepatobiliary
diseases.
Interestingly,
exhibit
different
effects
on
progression
tumor
tissues,
suppression
promotion.
addition,
currently
being
studied
as
potential
diagnostic
targets,
claudin-3,
claudin-4,
claudin-18.2,
etc.
this
article,
functional
phenotype,
molecular
mechanism,
targeted
application
reviewed,
an
emphasis
claudin-1,
claudin-7
current
situation
future
prospects
proposed.
Language: Английский