Pathological and Inflammatory Consequences of Aging

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 404 - 404

Published: March 12, 2025

Aging is a complex, progressive, and irreversible biological process that entails numerous structural functional changes in the organism. These affect all bodily systems, reducing their ability to respond adapt environment. Chronic inflammation one of key factors driving development age-related diseases, ultimately causing substantial decline abilities older individuals. This persistent inflammatory state (commonly known as “inflammaging”) characterized by elevated levels pro-inflammatory cytokines, an increase oxidative stress, perturbation immune homeostasis. Several factors, including cellular senescence, contribute this milieu, thereby amplifying conditions such cardiovascular disease, neurodegeneration, metabolic disorders. Exploring mechanisms chronic aging essential for developing targeted interventions aimed at promoting healthy aging. review explains strong connection between inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, lifestyle changes.

Language: Английский

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Linagliptin Mitigates DMH‐Induced Colorectal Cancer in Rats: Crosstalk Between NFAT and IL‐6/JAK2/STAT3/NF‐κB Signaling Hubs

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)

Published: March 1, 2025

ABSTRACT Colorectal cancer (CRC) is a multicomponent disease and the second most frequent root of cancer‐related deaths globally. Linagliptin dipeptidyl peptidase‐4 (DPP‐4) inhibitor. It has been repurposed in recent experimental studies due to its marked anti‐inflammatory activities. This study aimed evaluate ameliorative role linagliptin 1,2‐dimethylhydrazine (DMH)‐induced CRC via modulation NFAT‐mediated IL‐6 JAK2/STAT3/NF‐κB signaling pathways. model successfully established dose equal 40 mg/kg two times week DMH for 8‐week duration. Twenty‐four Wistar rats were segregated into three groups eight each; normal control, DMH‐induced + (10 mg/kg; p.o). attenuated oxidative stress by restoring declined levels some antioxidant enzymes. suppressed elevated nuclear factor kappa B (NF‐κB) induced which highlighted using immunohistochemistry analysis. The fortified decline activated T‐cells (NFAT) mRNA expression level along with reduction vascular endothelial growth (VEGF), interlukin‐6 (IL‐6) cyclooxygenase‐2 (COX‐2) levels. mitigate protein DMH‐activated oncogenic janus‐activated kinase/signal transducers activators transcription (JAK2/STAT3). exerted proapoptotic effect tumor cells manifested remarkable B‐cell lymphoma 2 (Bcl‐2) significant elevation Bcl‐2‐associated X (Bax) histopathological analysis revealed that inhibitory potential against dysplastic aberrant crypt foci (ACF) adenocarcinoma. ameliorated modulating cascades.

Language: Английский

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The role of inflammation in colorectal Cancer and the preventive potential of natural compounds

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106857 - 106857

Published: May 15, 2025

Language: Английский

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Targeting inflammation in cancer therapy: from mechanistic insights to emerging therapeutic approaches

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 26, 2025

Abstract Inflammation is a complex and finely tuned component of the host defense mechanism, responding sensitively to range physical, chemical, biological stressors. Current research advancing our grasp both cellular molecular mechanisms that initiate regulate interactions within inflammatory pathways. Substantial evidence now indicates profound link between inflammation, innate immunity, cancer. Dysregulation pathways known be pivotal factor in induction, growth, metastasis tumors through multiple mechanistic Basically, tumor microenvironment (TME), characterized by dynamic interplay cancerous cells surrounding stromal cells, plays central role these processes. Increasingly, controlled acute inflammation being explored as promising therapeutic tool certain types However, TME exhibit remarkable plasticity, with shifting phenotypic functional roles facilitate cancer cell survival, proliferation, migration, especially under chronic conditions. Additionally, signaling molecules associated immune system, like chemokines, are co-opted malignant support invasion, metastasis. These findings underscore need for deeper insights into connecting pathology, which could pave way innovative diagnostic approaches targeted anti-inflammatory therapies counter development. The current review underlines critical involvement development, examining connection key mediators, biomarkers, their We also discuss impact inflammation-targeted on anticancer Furthermore, we major drugs potential applications oncology, assessing how modulated management. Lastly, outline an overview ongoing discoveries field, highlighting challenges promise targeting therapy.

Language: Английский

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Weaving the gates of life: Pioneering a new era in oral gene delivery with metal-organic frameworks

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158522 - 158522

Published: Dec. 10, 2024

Language: Английский

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