NLRP3 inflammasome in cardiovascular diseases: an update DOI Creative Commons
Binhai Mo,

Y. Ding,

Qingwei Ji

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Cardiovascular disease (CVD) continues to be the leading cause of mortality worldwide. The nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is involved in numerous types CVD. As part innate immunity, NLRP3 plays a vital role, requiring priming activation signals trigger inflammation. leads both release IL-1 family cytokines distinct form programmed cell death called pyroptosis. Inflammation related CVD has been extensively investigated relation inflammasome. In this review, we describe pathways triggering discuss its pathogenic effects on This study also provides an overview potential therapeutic approaches targeting

Language: Английский

Recent advances in the role of gasotransmitters in necroptosis DOI Creative Commons
Marlene M. Hao, Kai Li,

Hang-Shen Han

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

0
NLRP3 inflammasome in cardiovascular diseases: an update DOI Creative Commons
Binhai Mo,

Y. Ding,

Qingwei Ji

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Cardiovascular disease (CVD) continues to be the leading cause of mortality worldwide. The nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is involved in numerous types CVD. As part innate immunity, NLRP3 plays a vital role, requiring priming activation signals trigger inflammation. leads both release IL-1 family cytokines distinct form programmed cell death called pyroptosis. Inflammation related CVD has been extensively investigated relation inflammasome. In this review, we describe pathways triggering discuss its pathogenic effects on This study also provides an overview potential therapeutic approaches targeting

Language: Английский

Citations

0