Role of Decidual Natural Killer Cells in the Pathogenesis of Preeclampsia DOI Open Access

Shuang Yue,

Jinlai Meng

American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 93(1)

Published: Dec. 30, 2024

Preeclampsia is one of the most severe obstetric complications, yet its pathogenesis remains unclear. Decidual natural killer (dNK) cells, abundant immune cells at maternal-fetal interface, are closely associated with preeclampsia due to abnormalities in their quantity, phenotype, and function. This review summarizes molecular mechanisms by which dNK regulate extravillous trophoblast (EVT) invasion, promote uterine spiral artery remodeling, maintain tolerance. Furthermore, it explores how disruptions these changes decidual microenvironment alter cell properties, driving progression preeclampsia. Understanding identifying potential therapeutic targets may provide new insights for clinical intervention.

Language: Английский

Recent Advances in Multimodal Approaches for Investigating Placental Development and Related Diseases DOI
Hao Wang, Tao Zhang, Jing Ruan

et al.

Placenta, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Integrated multi-omics analysis reveals immunovascular mechanisms of the placenta-maternal brain axis and lifespan neurobehavior changes in a mouse model of preeclampsia DOI
Serena B. Gumusoglu,

Brianna Blaine,

Aimee X Bertolli

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Role of Decidual Natural Killer Cells in the Pathogenesis of Preeclampsia DOI Open Access

Shuang Yue,

Jinlai Meng

American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 93(1)

Published: Dec. 30, 2024

Preeclampsia is one of the most severe obstetric complications, yet its pathogenesis remains unclear. Decidual natural killer (dNK) cells, abundant immune cells at maternal-fetal interface, are closely associated with preeclampsia due to abnormalities in their quantity, phenotype, and function. This review summarizes molecular mechanisms by which dNK regulate extravillous trophoblast (EVT) invasion, promote uterine spiral artery remodeling, maintain tolerance. Furthermore, it explores how disruptions these changes decidual microenvironment alter cell properties, driving progression preeclampsia. Understanding identifying potential therapeutic targets may provide new insights for clinical intervention.

Language: Английский

Citations

0