The role of transcytosis in the blood-retina barrier: from pathophysiological functions to drug delivery DOI Creative Commons
Chunlin Zhang,

Jing-Jie Ma,

Xiang Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

The blood-retina barrier (BRB) serves as a critical interface that separates the retina from circulatory system, playing an essential role in preserving homeostasis of microenvironment within retina. Specialized tight junctions and limited vesicle trafficking restrict paracellular transcellular transport, respectively, thereby maintaining BRB properties. Additionally, transcytosis macromolecules through retinal vascular endothelial cells constitutes primary mechanism for transporting substances compartment into surrounding tissue. This review summarizes fundamental aspects including its function healthy retina, biochemical properties transcytosis, methodologies used to study this process. Furthermore, we discuss current understanding context pathological breakdown present recent findings highlight significant advances drug delivery based on transcytosis.

Language: Английский

The role of transcytosis in the blood-retina barrier: from pathophysiological functions to drug delivery DOI Creative Commons
Chunlin Zhang,

Jing-Jie Ma,

Xiang Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

The blood-retina barrier (BRB) serves as a critical interface that separates the retina from circulatory system, playing an essential role in preserving homeostasis of microenvironment within retina. Specialized tight junctions and limited vesicle trafficking restrict paracellular transcellular transport, respectively, thereby maintaining BRB properties. Additionally, transcytosis macromolecules through retinal vascular endothelial cells constitutes primary mechanism for transporting substances compartment into surrounding tissue. This review summarizes fundamental aspects including its function healthy retina, biochemical properties transcytosis, methodologies used to study this process. Furthermore, we discuss current understanding context pathological breakdown present recent findings highlight significant advances drug delivery based on transcytosis.

Language: Английский

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