Electrospun miRNA-21@doxycycline core-sheath nanofibers for a synergistic treatment of diabetic wounds DOI
Minghui Xu, Xudong Yao, Yichen Wang

et al.

Composites Communications, Journal Year: 2024, Volume and Issue: unknown, P. 102239 - 102239

Published: Dec. 1, 2024

Language: Английский

Topical Biocomposites Based on Collagen, Hyaluronic Acid and Metronidazole as Periodontitis Treatment DOI Creative Commons
Mădălina Georgiana Albu Kaya,

Alice Geanina Simonca,

Ileana Rău

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1336 - 1336

Published: Oct. 7, 2024

It is well known that periodontitis affects the gums and surrounding connective tissue. The chronic inflammatory response induced by bacteria in gingival tissue leads to loss of collagen connection between tooth bone ultimately loss.

Language: Английский

Citations

1
Insights into electrospun polymeric nanofiber mats: an innovative dressing for wound healing applications DOI
Bimal Rajchal, Yub Narayan Thapa, Dipesh Karki

et al.

Polymer International, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Wound management is a complex clinical challenge that needs advanced materials and techniques for satisfactory results. Electrospun nanofiber mats have emerged as an innovative alternative wound healing purposes due to their porous architecture, greater surface area, ease of water absorption, mimicry the extracellular matrix natural tissues tunable mechanical properties. This paper sheds light on recent advances in fabrication techniques, properties, structural features application electrospun polymeric emphasizing importance polymer selection processing parameters tailoring physicochemical Furthermore, review explores underlying principles process various approaches incorporating bioactive agents into enhance biological performance potential. The possibility embedding stimuli‐responsive sensors develop smart also briefly explored. © 2024 Society Chemical Industry.

Language: Английский

Citations

0
Electrospun 11β-HSD1 Inhibitor-Loaded Scaffolds for Accelerating Diabetic Ulcer Healing DOI
Xiaofeng Ding, Heyan Huang, Y. Chen

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Diabetic ulcers (DUs) are a common and severe complication of diabetes, characterized by impaired wound healing due to complex pathophysiological mechanism. Elevated levels 11β-hydroxysteroid dehydrogenase type I (11β-HSD1) in wounds have been demonstrated modulate glucocorticoid activity, leading delayed skin cell proliferation restricted angiogenesis, ultimately hindering healing. In this study, we propose an electrospun poly(ε-caprolactone) (PCL) nanofiber scaffold doped with the 11β-HSD1 inhibitor BVT2733 (BPs) prevent activity during diabetic process. The loaded is designed achieve localized inhibition DUs. This exhibited porous morphology desirable drug-loading capacity, meeting requirements for coverage effective delivery BPs. vitro studies that sustained release from promoted migration while stimulating angiogenesis upregulating HIF1-α/VEGF expression. therapeutic effect was further confirmed full-thickness model using mice. mice treated scaffolds accelerated rate, increased neovascularization, enhanced collagen deposition, regeneration appendages within 2 weeks postinjury. findings here provide evidence use inhibitor-integrated biomaterials treating DUs represent novel biological platform modulating dysregulated mechanisms

Language: Английский

Citations

0
Electrospun miRNA-21@doxycycline core-sheath nanofibers for a synergistic treatment of diabetic wounds DOI
Minghui Xu, Xudong Yao, Yichen Wang

et al.

Composites Communications, Journal Year: 2024, Volume and Issue: unknown, P. 102239 - 102239

Published: Dec. 1, 2024

Language: Английский

Citations

0