Understanding the Link Between Neural Activity and Immune Function DOI
Aparna Prashanth, K. Jayasankara Reddy

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 249 - 270

Published: Dec. 13, 2024

This chapter investigates the intricate connections between neural activity and immune function, drawing on insights from both neuropsychology psychoneuroimmunology. A better understanding of role brain mental health in regulating immunological responses general wellbeing is overarching goal. In order to determine neuronal circuits neurotransmitter systems controlling emotional reactions stress, we begin by going over basic ideas neuropsychology. delves into ways which these influence incorporating It examines mediating functions neurotransmitters hormones system's response among other topics. The consequences issues including persistent anxiety, depression, are highlighted particular. We highlight two way nature discussing how changes function might impact health.

Language: Английский

Chaihu Shugan San Exerts Antidepressant Effects by Regulating Glucocorticoid Metabolism in CUMS Rats and Network Pharmacology Provides Complementary Mechanistic Insights DOI Creative Commons

Yusen Xu,

Xuemei Han, Ying Zhu

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 6780 - 6793

Published: Feb. 16, 2025

Traditional Chinese medicine Chaihu Shugan San (CSGS) is a classic herb prescription for improving depression, but its specific molecular mechanism has not been fully clarified. This study integrates network pharmacology and experimental validation to investigate CSGS's antidepressant effects, focusing on impact GC metabolism related pathways. In this research, the of CSGS in relation depression model induced by chronic unpredictable mild stress will be discussed. High-performance liquid tandem mass spectrometry was applied verification grown metabolites' economic vitality rat plasma prefrontal cortex. The revelation behavioral test results showed that administration improved symptoms significantly at end period, which 8 weeks. Network used assist verifying active ingredients affect glucocorticoid metabolic pathway exert effects. (GC) reducing corticosterone (CORT) levels increasing dehydrocorticosterone (11-DHCORT) 11-DHCORT/CORT ratio PFC. It regulated liver PFC downregulating synthase (11β-HSD1) upregulating enzymes (11β-HSD2). Additionally, restored signaling GR HSP-90α, FKBP51 HSP-70, alleviating inflammation inhibiting NF-κB P65 HAT expression. These particularly PFC, were stronger than those with fluoxetine. revealed targets multiple pathways including PI3K-Akt, FoxO, HIF-1, mTOR. indicate can improve depressive state rats regulating other as well downstream proteins.

Language: Английский

Citations

1
Changes in the Expression Profile of Growth-Associated Protein 43 in Degenerative Lumbosacral Stenosis DOI Open Access

Dawid Sobański,

Małgorzata Sobańska,

Rafał Staszkiewicz

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1223 - 1223

Published: Feb. 13, 2025

Background: Degenerative spinal stenosis is a common condition associated with structural degeneration and pain, yet its molecular underpinnings remain incompletely understood. Growth-associated protein 43 (GAP-43), key player in neuronal plasticity regeneration, may serve as biomarker for disease progression pain severity. This study investigates the expression of GAP-43 at mRNA levels ligamentum flavum affected patients. Methods: Samples were collected from 96 patients degenerative 85 controls. was analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), while quantified via enzyme-linked immunosorbent assay (ELISA) Western blot. Pain severity assessed visual analog scale (VAS), associations lifestyle factors analyzed. Results:GAP-43 significantly downregulated group compared to controls (fold change = 0.58 ± 0.12, p < 0.05), an inverse correlation VAS 0.76 4 vs. 0.36 10). Conversely, markedly elevated (5.57 0.21 ng/mL) when (0.54 0.87 ng/mL, 0.0001). Protein also correlated factors, including smoking alcohol consumption (p 0.05). Conclusions: shows potential stenosis, manner influenced by factors. Further research needed explore diagnostic therapeutic applications.

Language: Английский

Citations

0
Enteric nervous system dysfunction as a driver of central nervous system disorders: The Forgotten brain in neurological disease DOI

Orabi Hajjeh,

Islam Rajab, Mohammad Bdair

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 572, P. 232 - 247

Published: March 13, 2025

Language: Английский

Citations

0
Remission of OCD and ulcerative colitis with a ketogenic diet: Case Report DOI Creative Commons
Lori Calabrese

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

There is little research describing the clinical use of a ketogenic diet in obsessive-compulsive disorder (OCD) or inflammatory bowel disease. We describe first application adult OCD with ulcerative colitis (UC) resulting complete remission OCD, UC, and improved metabolic health. A 37-year-old obese woman longstanding was treated for 12 weeks personalized whole-food (KMT 1:5:1 ratio) specialized psychiatry clinic. Adherence assessed by capillary beta-hydroxybutyrate (BHB) photojournaling food intake. Remission Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Florida Inventory scale (FOCI), Clinical Global Impression-Improvement/Severity (CGI-S/I). Patient Health Questionnaire-9 (PHQ-9) Yale Food Addictions 2.0 (YFAS 2.0) depression addiction. UC Partial Mayo Score (PMS) Ulcerative Colitis Patient-Reported Outcome (UC-PRO). Metabolic health laboratories bioimpedance. Quality life using validated scales flourishing, resilience, self-compassion, subjective narrative. occurred within 3 (PMS 0, UC-PRO 0). Progressive improvement inversely related to oscillating BHB, FOCI 0 at 9 weeks, (Y-BOCS CGI-S 1). Body weight decreased 12.2%, significant decreases percentage body fat visceral fat. Flourishing, self-compassion 2- 20-fold. Complete marked well-formulated ratio 1:5:1) meaningful positive impact on quality improvements self-compassion.

Language: Английский

Citations

0
Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective DOI
Falguni Goel,

Daksh Kumar,

Anushka Sharma

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Revolutionizing Neuroimmunology: Unraveling Immune Dynamics and Therapeutic Innovations in CNS Disorders DOI Open Access
Corneliu Toader,

Călin Petru Tătaru,

Octavian Munteanu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13614 - 13614

Published: Dec. 19, 2024

Neuroimmunology is reshaping the understanding of central nervous system (CNS), revealing it as an active immune organ rather than isolated structure. This review delves into unprecedented discoveries transforming field, including emerging roles microglia, astrocytes, and blood–brain barrier (BBB) in orchestrating neuroimmune dynamics. Highlighting their dual both repair disease progression, we uncover how these elements contribute to intricate pathophysiology neurodegenerative diseases, cerebrovascular conditions, CNS tumors. Novel insights microglial priming, astrocytic cytokine networks, meningeal lymphatics challenge conventional paradigms privilege, offering fresh perspectives on mechanisms. work introduces groundbreaking therapeutic innovations, from precision immunotherapies controlled modulation BBB using nanotechnology focused ultrasound. Moreover, explore fusion with neuromodulatory technologies, underscoring new frontiers for personalized medicine previously intractable diseases. By synthesizing advancements, propose a transformative framework that integrates cutting-edge research clinical translation, charting bold path toward redefining management era neuroimmunology.

Language: Английский

Citations

1
Understanding the Link Between Neural Activity and Immune Function DOI
Aparna Prashanth, K. Jayasankara Reddy

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 249 - 270

Published: Dec. 13, 2024

This chapter investigates the intricate connections between neural activity and immune function, drawing on insights from both neuropsychology psychoneuroimmunology. A better understanding of role brain mental health in regulating immunological responses general wellbeing is overarching goal. In order to determine neuronal circuits neurotransmitter systems controlling emotional reactions stress, we begin by going over basic ideas neuropsychology. delves into ways which these influence incorporating It examines mediating functions neurotransmitters hormones system's response among other topics. The consequences issues including persistent anxiety, depression, are highlighted particular. We highlight two way nature discussing how changes function might impact health.

Language: Английский

Citations

0