Editorial: New techniques in microbiome research - volume II: Host-microbiome interactions using ‘meta-omics’ techniques

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 5, 2025

influence human metabolic pathways, offering potential avenues for early diagnosis and targeted therapy.Therapeutic Interventions. Understanding microbiome-disease associations has led to the exploration of microbiome-based therapies. Probiotic prebiotic interventions, as well fecal microbiota transplantation (FMT), are being investigated their restore healthy microbiome composition mitigate disease progression. FMT gained traction a treatment recurrent Clostridioides difficile (C. difficile) infections been explored its role in other conditions such IBD (5).The impact on cancer one most intriguing areas research. Studies suggest that can progression, immune response, even efficacy For example, research shown microbial species residing tumor microenvironment modulate checkpoints affect response immunotherapy. have certain species, Fusobacterium nucleatum, exacerbate colorectal by promoting inflammation genomic instability (6).Microbiome neurological disorders. The gut-brain axis become focal point into neurodegenerative diseases. Meta-omics approaches gut dysbiosis health altering metabolite production, which turn affects neuroinflammation brain function (7). This emerging evidence suggests may play crucial development diseases Parkinson's Alzheimer's, new opportunities therapies.The profoundly impacts susceptibility defense. Dysbiosis body gut, vaginal, skin microbiomes is associated with an increased risk (8). Similarly, compromises function, leading greater gastrointestinal infections, including C. infection (9). Research also highlights gut-lung axis, showing imbalances respiratory suggesting systemic maintaining homeostasis Moreover, sputum severe critically ill influenza patients (10), In addition, indicates alter SARS-CoV-2 virus load COVID-19 severity (11).Microbiome women health. plays critical women's health, particularly context vaginal microbiomes. microbiome, typically dominated Lactobacillus essential environment producing lactic acid acidic pH. Disruptions this balance result bacterial vaginosis, yeast sexually transmitted (STIs) (12). cases vaginosis dysbiosis, increase pathogens like Gardnerella vaginalis Prevotella linked adverse reproductive outcomes, infertility miscarriage (12)(13).In oral changes menstrual cycle. Different profiles were observed during follicular phase, late luteal phases. Alpha diversity beta analyses revealed distinct across four phases (14). lactobacilli used (15). urinary signatures different types diversion (16).Furthermore, significant implications hormonal regulation responses, polycystic ovary syndrome (PCOS) pregnancy outcomes. alterations insulin resistance, imbalances, PCOS, contributing symptoms disturbances (12) (13).The aim Topic offer platform articles expand our understanding host-microbiome interactions using 'meta-omics' techniques. collection includes 5 reviews 14 original articles, highlighting between various These contributions made strides advancing knowledge complex interplay states, cancers (Lin et al. Microbial influences mechanism, prognosis, diagnosis, therapy. A comprehensive review examines intratumoral mechanisms, treatment. It delves roles microbiota, emphasizing responses. Additionally, provides overview recent microbiome-cancer research, summarizing key findings from literature, past current advancements, discussing novel techniques, identifying gaps, outlining future goals. explores cancer, detailed analysis rapidly evolving field (Lin, al., 2025). tract lung investigates communities inhabiting regions system (Cheng, 2024). could mediating oncogenesis through potentially opening therapeutic interventions (Li, 2023). Colorectal (CRC)-associated Porphyromonas endodontalis, Ruminococcus torques, Odoribacter splanchnicus. stage-specific taxa identified, aid diagnosing polyps (BP) CRC stages (Cai Furthermore, specific pathways occurrence series immune-related events (irAEs) gastric, esophageal, colon cancers. Notably, callidus Bacteroides xylanisolvens enriched without irAEs. Several citrulline arginine biosynthesis, irAE (Zhang 2023).The authors reviewed innovative single cell sequencing broad applications addressing questions regarding spatial heterogeneity. advancements deeper insights functional individual cells within (Madhu, etal., microbiota-gut-brain pivotal regulating neuroprotective functions host. Patients (PD) often exhibit (Jia, he appear long-term depression (Li identification classes Negativicutes Selenomonadales direction strategies manage sleep disorders via modulation (Wang, another study, ten (GM) found causal insomnia 2023).Oral During relative abundance Streptococcus genus was significantly higher compared phases, while 7 6 genera exhibited lower phase than notably (Yamazaki 2023).Use probiotic infections. Lactobacilli microenvironment. treating female contribute restoring preserving competing pathogenic bacteria, enhancing local antimicrobial substances (Liu, diversion. studied. Urinary landscapes radical cystectomy (UD) analyzed 2024).Sputum characteristics patients. Bacteroidetes showed depletion cohort. group marked overrepresentation Neisseria, Porphyromonas, Actinobacillus, Alloprevotella, Nanosynbacter lyticus TM7x, Clostridia UCG-014. Alloprevotella inverse correlation cycle threshold (Ct) values. C-reactive protein (CRP) levels demonstrated positive presence Haemophilus (Gu, infection. Distinct patterns identified among individuals, colonized patients, those (CDI), (R-CDI), non-Clostridioides (NOCDI) diarrhea. Potential biomarkers discovered be valuable distinguishing true CDI conditions, improving diagnostic accuracy guiding (Vázquez-Cuesta, 2023).Gut children split-dose bowel preparations. pediatric undergoing PEG preparation colonoscopy, at genus, pathway levels. However, no phylum level (Zou, 2023).Correlations fungal clinical parameters Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) (Niu, One study reveals differences cholesterol pigment gallstone 2024).A combination NaClO H₂O₂ more effective disinfectant, against pathogens, alternative solution efficient control 2022).In conclusion, integration meta-omics techniques revolutionized ability explore microbiome's diseases, providing As these continue evolve, they hold immense promise targets wide range

Language: Английский

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Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer's disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut-brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood-brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

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The Role of Gut Microbiota Dysbiosis in Erectile Dysfunction: From Pathophysiology to Treatment Strategies

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 250 - 250

Published: Jan. 23, 2025

Erectile dysfunction (ED) is a prevalent male sexual disorder characterized by the persistent inability to achieve or maintain an erection sufficient for satisfactory performance. While its etiology multifactorial, encompassing vascular, neurological, hormonal, and psychological components, emerging evidence suggests significant role gut microbiota dysbiosis in development. The influences various metabolic, inflammatory, neuropsychological processes critical erectile function. Dysbiosis can lead systemic inflammation, endothelial dysfunction, hormonal imbalances, altered neurotransmitter production, all of which are key factors ED pathogenesis. This narrative review synthesizes current research on association between alterations ED, highlighting specific bacterial taxa implicated through mechanisms involving metabolic disturbances, regulation. explores potential linking including pro-inflammatory cytokines, barrier integrity disruption, disorders, via gut–brain axis, Furthermore, offers promising avenues developing non-invasive biomarkers therapeutic interventions such as probiotics, prebiotics, dietary modifications, fecal transplantation. Future should focus longitudinal studies, mechanistic explorations, clinical trials validate these findings translate them into practice. Understanding interplay function could unveil novel diagnostic pave way innovative treatments targeting microbiota, ultimately improving men’s overall health.

Language: Английский

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The dynamics impact of phlorizin on gut microbiota and metabolites in an in vitro fermentation model

Food Research International, Journal Year: 2025, Volume and Issue: 205, P. 115930 - 115930

Published: Feb. 7, 2025

Language: Английский

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Intestinal Microbiota Dysbiosis Role and Bacterial Translocation as a Factor for Septic Risk

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2028 - 2028

Published: Feb. 26, 2025

The human immune system is closely linked to microbiota such as a complex symbiotic relationship during the coevolution of vertebrates and microorganisms. transfer microorganisms from mother's newborn begins before birth gestation considered initial phase intestinal (IM). gut an important site where can establish colonies. IM contains polymicrobial communities, which show interactions with diet host immunity. tendency towards dysbiosis influenced by local but also extra-intestinal factors inflammatory processes, infections, or septic state that aggravate it. Pathogens could trigger response, proinflammatory responses. In addition, changes in influence community structure additional translocation pathogenic non-pathogenic bacteria. Finally, inflammation has been found be factor growth microorganisms, particularly its role sepsis. aim this article able detect current knowledge mechanisms lead cause bacterial risk infection vice versa.

Language: Английский

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Factors Affecting Gut Microbiota and Its Relationship with Cardiovascular Diseases: A Narrative Review

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 16, 2025

Context: The estimated population of microorganisms inhabiting the gastrointestinal tract is thought to exceed 1014, with a total weight approximately 2 kg. This accumulation microbiota indicates that number bacterial cells ten times greater than human cells, and gene content exceeds genome by more hundredfold. These are essential for maintaining health, having evolved over millions years. They influence vital processes in life, such as digestion regulation immune system. gut (GM) can be viewed dynamic environmental factor, its composition shaped host genetics, dietary patterns, hygiene practices, lifestyle choices. variability positions it potential therapeutic target cardiovascular disease (CVD) myocardial infarction (MI). Evidence Acquisition: present study review factors affecting intestinal relationship heart diseases. To ensure identification most relevant studies, common databases, including PubMed, Scopus, Web Science, were searched using terms "Gut dysbiosis", "Cardiovascular disease", "Probiotics", "prebiotics". articles abstracts obtained from search then reviewed. Results: Dysbiosis plays significant role onset progression atherosclerosis CVD. Microbiota-derived short-chain fatty acids (SCFAs) crucial development blood pressure. Alterations have been linked dysfunctions lipid metabolism, reduced levels high-density lipoprotein (HDL) plasma patients GM affect efficiency energy extraction sources, thereby impacting likelihood developing obesity through inflammation metabolism. Conclusions:

Language: Английский

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Cross-talks between osteoporosis and gut microbiome

World Journal of Orthopedics, Journal Year: 2025, Volume and Issue: 16(3)

Published: March 12, 2025

Language: Английский

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UPFs and Shortened Lifespans: Ultra-Processed Foods Linked to Accelerated Biological Aging; Consequences Across Human Body Systems and Implications for Associated Medical Specialties

Scientia. Technology, science and society., Journal Year: 2025, Volume and Issue: 2(3), P. 13 - 36

Published: March 1, 2025

Ultra-processed foods (UPFs) are defined by their high levels of refined carbohydrates, unhealthy fats, artificial additives, and preservatives. These contribute to biological aging through mechanisms such as chronic inflammation, oxidative stress, metabolic dysfunction. Inflammation, disruptions in insulin signaling key factors the development aging-related diseases, including cardiovascular disease, diabetes, neurodegenerative disorders. Specifically, advanced glycation end-products (AGEs) epigenetic modifications significantly acceleration disrupting cellular function, promoting tissue damage, driving disease development. UPF consumption is linked cancer, gastrointestinal disorders, obstetric gynecological conditions, a range adverse effects on various body systems. Reducing intake encouraging healthier dietary patterns crucial for mitigating impact UPFs related health conditions. For individuals unable transition whole food-based diets, pharmaceutical medical interventions offer alternatives reduce UPF-related aging. A combined approach pharmacologic therapies adjustments may optimize outcomes, with ongoing research into novel treatments further enhancing strategies counteract effects. This review examines accelerating aging, which they associated potential mitigate

Language: Английский

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Association between relative fat mass and risk of gallstones in adults

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 17, 2025

Gallstones (GS) are closely associated with obesity. The body mass index (BMI) is the most commonly used for evaluating However, BMI does not consider distribution of adipose tissue and differentiate between differences in fat by sex; therefore, only provides a rough indication overweight status. Relative (RFM) an emerging, simple, low-cost anthropometric that reflects obesity (particularly abdominal obesity), various obesity-related diseases. relationship RFM GS has yet been explored. Therefore, this study aimed to evaluate risk developing GS, age patients at time their first surgery, predictive value GS. Data from National Health Nutrition Examination Survey (2017–2020) were used. Logistic regression dose-response curves analyze levels prevalence Multiple linear patient surgery. Subgroup analyses further explored age, sex, race, hypertension, diabetes mellitus. Receiver operating characteristic (ROC) ability development. Overall, 7978 adults aged ≥ 20 years included study, whom 828 had history After adjusting potential confounders, each 1-unit increase was 9% (odds ratio: 1.09, 95% confidence interval : 1.07, 1.11), confirming positive, nonlinear correlation. And threshold effect on 40.99. revealed positive correlation remained stable all populations despite subtle differences. results ROC suggested superior BMI. In addition, surgery 30.99. general, higher better predictor than Due nature cross-sectional we unable determine causal two.

Language: Английский

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Infections, Genetics, and Alzheimer's Disease: Exploring the Pathogenic Factors for Innovative Therapies

Virology, Journal Year: 2025, Volume and Issue: unknown, P. 110523 - 110523

Published: March 1, 2025

Language: Английский

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