Biomarkers in Hereditary Spastic Paraplegias
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1950 - 1950
Published: Feb. 24, 2025
Hereditary
spastic
paraplegias
(HSPs)
represent
a
group
of
neurodegenerative
disorders
characterized
by
progressive
spasticity
and
weakness
in
the
lower
limbs,
with
no
specific
treatment
available
for
patients.
At
same
time,
molecular
diagnosis
is
complicated
high
genetic
heterogeneity
this
diseases,
it
can
be
challenging
due
to
overlapping
clinical
features
other
conditions.
Reliable
biomarkers
could
play
fundamental
role
diagnosis,
prognosis,
therapeutic
interventions
HSPs.
For
reason,
necessary
increase
search
that
used
rapidly
classify
HSPs,
follow
natural
history
conditions,
monitor
disease
correction
therapies.
This
article
provides
an
overview
current
understanding
including
genetic,
biochemical,
new
cell
imaging-based
approaches.
In
manuscript,
we
aim
provide
situation
HSP
biomarkers,
emphasizing
limitations
necessity
conducting
more
studies
field.
Language: Английский
The rise of 3D bioprinting advancements in modeling neurodegenerative diseases
Ibrain,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
Abstract
Neurodegenerative
diseases
(NDs)
are
disorders
that
drastically
alter
the
physiological
functioning
of
neurons
in
brain.
These
processes
often
accompanied
by
abnormal
protein
aggregates
physical
and
chemical
properties
brain
tissue
peripheral
nerves.
The
causes
NDs
complex,
involving
genetic
factors,
neuroinflammation,
oxidative
stress,
environmental
influences,
lifestyle,
while
symptoms
progression
vary
significantly
based
on
mechanisms
cell
death.
Currently,
no
definitive
treatment
exists
for
NDs,
as
underlying
degenerative
remain
poorly
understood.
Existing
therapies
focus
symptom
alleviation
but
insufficient
to
halt
or
prevent
disease
progression.
This
highlights
urgent
need
strategies
mimic
pathophysiology
facilitating
deeper
insights
development
effective
treatments.
Conventional
vitro
vivo
models
attempt
replicate
fail
capture
complexity
nervous
its
interactions.
In
this
context,
3D
microfluidic
bioprinting
emerges
a
transformative
technology.
By
enabling
precise
deposition
cells
biomaterials,
it
allows
creation
with
high
degree
structural
functional
complexity.
advancements
provide
valuable
platform
faithfully
modeling
bridging
critical
gaps
our
understanding,
paving
way
toward
innovative
therapeutic
approaches.
Language: Английский
Skin and Induced Pluripotent Stem Cells as Biomarkers for Neurodegenerative Diseases
Genes,
Journal Year:
2024,
Volume and Issue:
15(12), P. 1507 - 1507
Published: Nov. 25, 2024
As
the
global
population
ages,
rising
prevalence
of
neurodegenerative
diseases,
characterized
by
abnormal
protein
aggregates,
presents
significant
challenges
for
early
diagnosis
and
disease
monitoring.
Identifying
accessible
tissue
biomarkers
is
crucial
advancing
our
ability
to
detect
track
progression
these
diseases.
Among
most
promising
skin,
which
shares
a
common
embryological
origin
with
brain
central
nervous
system
(CNS).
This
biological
connection
positions
skin
as
potential
reflection
CNS
pathology.
Over
past
decades,
gene
expression
studies
have
demonstrated
that
key
genes
involved
in
diseases
are
also
expressed
tissues.
Genes
such
Language: Английский