Life Sciences in Space Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0315285 - e0315285
Published: March 13, 2025
With technological advancements, human’s desire to explore space is growing and more people are staying longer at the international station (ISS). The impact of microgravity on stem cells (SC) not fully understood. We explored gene expression profile cultured mesenchymal stem/stromal (MSCs) ISS. also evaluated how new knowledge gained sheds light our understanding human physiology Earth. Primary cultures MSCs were expanded ISS for 1 or 2 weeks mRNA was isolated from samples cells. Gene profiles determined compared with real-time ground control cultures. Differential expression, set enrichment analysis determination key genes performed that revealed first time existence potential “master regulators” coordinating a systemic response microgravity. Cyclin D1 (CCND1), protein-coding regulates cell cycle progression CDK kinases, identified as most connected regulator week 1. Further showed impacted significantly correlated known pathways associated division, chromosomal segregation nuclear extracellular matrix structure organization, muscle apoptosis differentiation. This study exemplifies utility research advance both Earth in space.
Language: Английский
Citations
0
Stem Cells Translational Medicine, Journal Year: 2025, Volume and Issue: 14(3)
Published: March 1, 2025
Abstract The still young and developing space age, characterized by lunar Martian exploration the vision of extraterrestrial settlements, presents a unique environment to study impact microgravity (µg) on human physiology disease development. Cancer research is currently key focus international science, as µg fundamentally impacts cellular processes like differentiation, adhesion, migration, proliferation, survival, cell death, or growth cancer cells well cytoskeleton extracellular matrix (ECM). By creating three-dimensional (3D) tumor models in µg-environment, multicellular spheroids (MCS), researchers can expedite drug discovery development, reducing need for animal testing. This concise review analyses latest knowledge influence MCS formation. We will from brain tumors, lung, breast, thyroid, prostate, gastrointestinal, skin exposed real (r-) simulated (s-) µg-conditions.
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 26, 2025
Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.
Language: Английский
Citations
0
Biotechnology Advances, Journal Year: 2025, Volume and Issue: unknown, P. 108574 - 108574
Published: April 1, 2025
Language: Английский
Citations
0
Life Sciences in Space Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0