The impact of allergic contact dermatitis on the inflammatory response and repair in wound healing process DOI Creative Commons
Wei Zhang, Jiabao Xu,

S Q Qu

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 19, 2025

Skin trauma and the subsequent wound healing process present significant challenges for healthcare systems patients globally. Allergic contact dermatitis (ACD) was a delayed-type hypersensitivity reaction that can disrupt normal repair due to prolonged inflammation immune dysregulation. However, specific impact of ACD on inflammatory response in remains incompletely understood. This study aimed investigate influence during process. retrospective cohort study. A total 120 with skin treated at Henan Provincial People's Hospital from January 2023 December were included. There 69 cases control 51 ACD. Inclusion exclusion criteria defined, various indicators, including patient data, factors, cell detection, assessment, measured analyzed using appropriate statistical methods. The revealed differences between groups. associated higher levels TNF-α, IL-6, IL-1β, C-reactive protein, IL-8 compared (p < 0.05). Additionally, group exhibited increased counts macrophages, neutrophils, T lymphocytes, B mast cells Moreover, linked delayed closure time distribution degrees Correlation analysis indicated associations among ACD, markers, cellular responses, time, degree demonstrates exerts substantial response, components, parameters context trauma. heightened altered observed underscore need targeted interventions tailored optimize this population.

Language: Английский

The impact of allergic contact dermatitis on the inflammatory response and repair in wound healing process DOI Creative Commons
Wei Zhang, Jiabao Xu,

S Q Qu

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 19, 2025

Skin trauma and the subsequent wound healing process present significant challenges for healthcare systems patients globally. Allergic contact dermatitis (ACD) was a delayed-type hypersensitivity reaction that can disrupt normal repair due to prolonged inflammation immune dysregulation. However, specific impact of ACD on inflammatory response in remains incompletely understood. This study aimed investigate influence during process. retrospective cohort study. A total 120 with skin treated at Henan Provincial People's Hospital from January 2023 December were included. There 69 cases control 51 ACD. Inclusion exclusion criteria defined, various indicators, including patient data, factors, cell detection, assessment, measured analyzed using appropriate statistical methods. The revealed differences between groups. associated higher levels TNF-α, IL-6, IL-1β, C-reactive protein, IL-8 compared (p < 0.05). Additionally, group exhibited increased counts macrophages, neutrophils, T lymphocytes, B mast cells Moreover, linked delayed closure time distribution degrees Correlation analysis indicated associations among ACD, markers, cellular responses, time, degree demonstrates exerts substantial response, components, parameters context trauma. heightened altered observed underscore need targeted interventions tailored optimize this population.

Language: Английский

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