Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents DOI Creative Commons
Alexandra Lupu, Maria Bercea, Mihaela Avădanei

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract Pluronic F127 copolymer is used as the main component to design injectable gels for therapeutic applications. Xanthan gum added an excipient improve gel properties under physiological conditions. A polyphenol bioactive compound, curcumin, selected agent with beneficial effects on metabolism and many diseases. The encapsulation efficiency stability of formulations are investigated in aqueous environment acetic acid solutions. interactions between hydrophobic polymer matrix through rheology, DLS, FTIR spectroscopy. viscoelasticity gels, correlated network structure, influenced by xanthan or addition. analysis curcumin incorporated into provides evidence interaction phenyl rings both keto‐enol di‐keto tautomers polymeric matrix. spherical curcumin‐encapsulated micelles provided antioxidant properties. kinetics release from F127‐based suggests anomalous transport phenomena controlled diffusion hydrodynamic effects. Both lyophilized form micellar encapsulated composites exhibited good long‐term storage ambient

Language: Английский

Development and Characterization of Niaprazine-Loaded Xanthan Gum-Based Gel for Oral Administration DOI Creative Commons
Elena Giuliano, E. Longo, Agnese Gagliardi

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 101 - 101

Published: Feb. 1, 2025

Niaprazine is a sedative-hypnotic drug initially developed as an antihistamine and used for its notable sedative effects, particularly in children. Following withdrawal from the market by producer, has been administered magistral formulations available syrup form, but there are several important disadvantages to this, including instability, taste issues, lack of controlled release, potential unreliable dosing due incomplete swallowing. There also increased risk dental caries, well fact that these not suitable children who suffer diabetes. The purpose current investigation prepare characterize xanthan gum-based gels oral administration niaprazine. appear transparent-whiteish, non-sticky substances, with uniformly dispersed throughout systems. They stable over time. Dynamic rheology revealed their advantageous shear-thinning properties, which enable formulation be flexibly dosed orally through via syringe. During experimentation, evaluation mucoadhesion features vitro release profile were performed. results demonstrate may represent alternative niaprazine syrup, allowing easy preparation, administration, compliance various categories patients, pediatric.

Language: Английский

Citations

0

Polysaccharides as therapeutic vehicles in pancreatic cancer DOI
Seema Kumari, Sujatha Peela,

Ganji Purnachandra Nagaraju

et al.

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104320 - 104320

Published: Feb. 1, 2025

Language: Английский

Citations

0

Rheological aspects of xanthan gum: Governing factors and applications in water-based drilling fluids and enhanced oil recovery DOI

Fuchang You,

Yu Wu, Yingying Guo

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123579 - 123579

Published: April 1, 2025

Language: Английский

Citations

0

Evaluation of Different Types of Paracetamol Active Pharmaceutical Ingredients' Effect on the Release System DOI Open Access
Şebnem Şenol

Journal of the Turkish Chemical Society Section A Chemistry, Journal Year: 2025, Volume and Issue: 12(2), P. 85 - 98

Published: March 24, 2025

The primary purpose of this study was to investigate the effect active pharmaceutical ingredients (APIs) with varying particle sizes and properties on drug release develop matrix-type tablets based poly(acrylic acid sodium salt) (PAANa) different gelatin ratios for enhanced paracetamol release. Micronized, superfine, purified APIs were selected as model drugs assess impact these Paracetamol is a frequently used medication in healthcare, so it crucial select API optimal rate an economical, environmentally friendly production method. direct compression method employed preparation due its simplicity ease integration industrial scale. studies, kinetics, scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), physical properties, microbial analyses (Escherichia coli, total mold, yeast) investigated. studies at pH 1.2 7.4 revealed that type ingredient, especially micronized superfine API, affects ratio. Microbial showed produced convenient health. In addition, prepared added gelatine can be deliver desired profile.

Language: Английский

Citations

0

Gamma Radiation as an Approach for the Synthesis of Silane-Crosslinked Xanthan Gum Films for Drug Delivery Applications DOI
Alejandra Ortega,

Eduardo Toral,

Guillermina Burillo

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112627 - 112627

Published: April 1, 2025

Language: Английский

Citations

0

Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents DOI Creative Commons
Alexandra Lupu, Maria Bercea, Mihaela Avădanei

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract Pluronic F127 copolymer is used as the main component to design injectable gels for therapeutic applications. Xanthan gum added an excipient improve gel properties under physiological conditions. A polyphenol bioactive compound, curcumin, selected agent with beneficial effects on metabolism and many diseases. The encapsulation efficiency stability of formulations are investigated in aqueous environment acetic acid solutions. interactions between hydrophobic polymer matrix through rheology, DLS, FTIR spectroscopy. viscoelasticity gels, correlated network structure, influenced by xanthan or addition. analysis curcumin incorporated into provides evidence interaction phenyl rings both keto‐enol di‐keto tautomers polymeric matrix. spherical curcumin‐encapsulated micelles provided antioxidant properties. kinetics release from F127‐based suggests anomalous transport phenomena controlled diffusion hydrodynamic effects. Both lyophilized form micellar encapsulated composites exhibited good long‐term storage ambient

Language: Английский

Citations

2