Development and Characterization of Niaprazine-Loaded Xanthan Gum-Based Gel for Oral Administration
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 101 - 101
Published: Feb. 1, 2025
Niaprazine
is
a
sedative-hypnotic
drug
initially
developed
as
an
antihistamine
and
used
for
its
notable
sedative
effects,
particularly
in
children.
Following
withdrawal
from
the
market
by
producer,
has
been
administered
magistral
formulations
available
syrup
form,
but
there
are
several
important
disadvantages
to
this,
including
instability,
taste
issues,
lack
of
controlled
release,
potential
unreliable
dosing
due
incomplete
swallowing.
There
also
increased
risk
dental
caries,
well
fact
that
these
not
suitable
children
who
suffer
diabetes.
The
purpose
current
investigation
prepare
characterize
xanthan
gum-based
gels
oral
administration
niaprazine.
appear
transparent-whiteish,
non-sticky
substances,
with
uniformly
dispersed
throughout
systems.
They
stable
over
time.
Dynamic
rheology
revealed
their
advantageous
shear-thinning
properties,
which
enable
formulation
be
flexibly
dosed
orally
through
via
syringe.
During
experimentation,
evaluation
mucoadhesion
features
vitro
release
profile
were
performed.
results
demonstrate
may
represent
alternative
niaprazine
syrup,
allowing
easy
preparation,
administration,
compliance
various
categories
patients,
pediatric.
Language: Английский
Polysaccharides as therapeutic vehicles in pancreatic cancer
Seema Kumari,
No information about this author
Sujatha Peela,
No information about this author
Ganji Purnachandra Nagaraju
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et al.
Drug Discovery Today,
Journal Year:
2025,
Volume and Issue:
unknown, P. 104320 - 104320
Published: Feb. 1, 2025
Language: Английский
Rheological aspects of xanthan gum: Governing factors and applications in water-based drilling fluids and enhanced oil recovery
Fuchang You,
No information about this author
Yu Wu,
No information about this author
Yingying Guo
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et al.
Carbohydrate Polymers,
Journal Year:
2025,
Volume and Issue:
unknown, P. 123579 - 123579
Published: April 1, 2025
Language: Английский
Evaluation of Different Types of Paracetamol Active Pharmaceutical Ingredients' Effect on the Release System
Journal of the Turkish Chemical Society Section A Chemistry,
Journal Year:
2025,
Volume and Issue:
12(2), P. 85 - 98
Published: March 24, 2025
The
primary
purpose
of
this
study
was
to
investigate
the
effect
active
pharmaceutical
ingredients
(APIs)
with
varying
particle
sizes
and
properties
on
drug
release
develop
matrix-type
tablets
based
poly(acrylic
acid
sodium
salt)
(PAANa)
different
gelatin
ratios
for
enhanced
paracetamol
release.
Micronized,
superfine,
purified
APIs
were
selected
as
model
drugs
assess
impact
these
Paracetamol
is
a
frequently
used
medication
in
healthcare,
so
it
crucial
select
API
optimal
rate
an
economical,
environmentally
friendly
production
method.
direct
compression
method
employed
preparation
due
its
simplicity
ease
integration
industrial
scale.
studies,
kinetics,
scanning
electron
microscope
(SEM),
Fourier
transform
infrared
spectroscopy
(FT-IR),
physical
properties,
microbial
analyses
(Escherichia
coli,
total
mold,
yeast)
investigated.
studies
at
pH
1.2
7.4
revealed
that
type
ingredient,
especially
micronized
superfine
API,
affects
ratio.
Microbial
showed
produced
convenient
health.
In
addition,
prepared
added
gelatine
can
be
deliver
desired
profile.
Language: Английский
Gamma Radiation as an Approach for the Synthesis of Silane-Crosslinked Xanthan Gum Films for Drug Delivery Applications
Materials Today Communications,
Journal Year:
2025,
Volume and Issue:
unknown, P. 112627 - 112627
Published: April 1, 2025
Language: Английский
Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents
Macromolecular Materials and Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 23, 2024
Abstract
Pluronic
F127
copolymer
is
used
as
the
main
component
to
design
injectable
gels
for
therapeutic
applications.
Xanthan
gum
added
an
excipient
improve
gel
properties
under
physiological
conditions.
A
polyphenol
bioactive
compound,
curcumin,
selected
agent
with
beneficial
effects
on
metabolism
and
many
diseases.
The
encapsulation
efficiency
stability
of
formulations
are
investigated
in
aqueous
environment
acetic
acid
solutions.
interactions
between
hydrophobic
polymer
matrix
through
rheology,
DLS,
FTIR
spectroscopy.
viscoelasticity
gels,
correlated
network
structure,
influenced
by
xanthan
or
addition.
analysis
curcumin
incorporated
into
provides
evidence
interaction
phenyl
rings
both
keto‐enol
di‐keto
tautomers
polymeric
matrix.
spherical
curcumin‐encapsulated
micelles
provided
antioxidant
properties.
kinetics
release
from
F127‐based
suggests
anomalous
transport
phenomena
controlled
diffusion
hydrodynamic
effects.
Both
lyophilized
form
micellar
encapsulated
composites
exhibited
good
long‐term
storage
ambient
Language: Английский