Extraction, purification, structural characterization, and anti-inflammatory activity of a polysaccharide from Lespedeza formosa

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140154 - 140154

Published: Jan. 1, 2025

Language: Английский

---

The modification effect of concentration on the correlation between ambient ozone and psoriasis: a hospital-based time-series study

International Journal of Biometeorology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

---

Evaluation of the expression of FLG, AHR and ARNT genes in the skin of patients with atopic dermatitis after phototherapy

Vestnik dermatologii i venerologii, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Background: Ultraviolet irradiation of the skin can activate cytoplasmic aryl hydrocarbon receptor AhR, which, in combination with its nuclear translocator ARNT binds to promoter FLG gene encoding filaggrin, a protective barrier protein. This suggests that therapeutic effect phototherapy may be due not only immunosuppressive effect, but also stimulation filaggrin production. Aims: evaluate ultraviolet used for various methods on expression levels FLG, AHR and genes patients atopic dermatitis. Materials methods: The were determined using real-time PCR. To define severity disease, SCORAD index was calculated. Results: 76 dermatitis included study. 37 underwent narrow-band phototherapy; 39 – UFA1 therapy. Both effective. After phototherapy, level significantly increased. therapy, increased, no changes observed. Conclusions: Data have been obtained indicating skin. revealed indicate possible involvement their protein products AhR pathogenesis disease.

Language: Английский

---

Polyphenol Microneedles for Dermatological Therapy

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Dermatological diseases represent one of the most prevalent health concerns globally, with associated care and treatment costs having consistently increased over past decade. Current therapeutic modalities, including topical medications, oral pharmaceuticals, physical therapies, frequently face challenges such as inadequate drug absorption substantial adverse effects. Microneedles, recognized minimally invasive delivery systems, effectively penetrate cutaneous barrier to enhance permeability efficacy. Polyphenols—abundant in botanical marine sources—demonstrate diverse pharmacological properties encompassing anti‐inflammatory antioxidant activities. The integration polyphenols microneedle technology has emerged a promising strategy for dermatological conditions, demonstrating significant clinical potential. This review examines multifunctional capabilities polyphenol‐incorporated microneedles elucidates their mechanisms action managing disorders. Furthermore, it synthesizes recent progress polyphenol‐based applications various pathologies, acne vulgaris, psoriasis, atopic dermatitis. Finally, current is discussed proposed future research directions optimizing polyphenol systems therapeutics.

Language: Английский

---

Advances in the Study of Exosomal MicroRNA in Psoriasis

Journal of Clinical Personalized Medicine, Journal Year: 2025, Volume and Issue: 04(02), P. 583 - 593

Published: Jan. 1, 2025

Language: Английский

---