Global burden of Type 2 Diabetes Mellitus attributable to dietary risks in elderly adults: insights from the Global Burden of Disease study 2021 DOI Creative Commons
Yiting Tang, Yupeng Chen, Yang Zhou

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 24, 2025

Background Type 2 Diabetes Mellitus (T2DM) poses a significant global health challenge, particularly among elderly adults. Dietary risk factors, such as high consumption of processed meats and sugar-sweetened beverages low intake whole grains fruits, play critical role in the burden T2DM. This study aims to comprehensively quantify T2DM attributable dietary risks adults, identify factors driving disease burden, evaluate temporal, regional, demographic variations inform targeted public strategies interventions for reducing impact Methods utilized data from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021 assess adults aged 65 years older across 204 countries territories. Metrics included age-standardized mortality rates (ASMR) disability-adjusted life-year (ASDR). analyzed grains, vegetables, fiber, well meat, red beverages. Joinpoint regression decomposition analyses were performed examine temporal trends drivers changes by region, SDI level, sex, age. Results In 2021, accounted 23.61% T2DM-related deaths 24.85% DALYs ASMR showed slight decline globally (AAPC: −0.08), while ASDR exhibited upward trend +0.7) 1990 2021. High regions demonstrated decreasing but persistent due prolonged survival with complications. Conversely, middle rapid increases ASDR, driven transitions limited healthcare resources. Males consistently bore higher than females, pronounced disparities regions. Aging population growth primary increasing globally. Conclusion underscores substantial highlights regional disparities. Targeted interventions, personalized nutritional strategies, improved access are essential mitigate this burden. Future research should explore emerging precision nutrition on prevention management.

Language: Английский

Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications DOI Creative Commons
Alfredo Caturano,

Maria Rocco,

Giuseppina Tagliaferri

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 72 - 72

Published: Jan. 9, 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which leading cause morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to complications oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production body’s antioxidant defenses. Hyperglycemia in promotes stress through various pathways, including formation advanced glycation end products, activation protein kinase C, mitochondrial dysfunction, polyol pathway. These processes enhance ROS generation, endothelial vascular inflammation, exacerbation damage. Additionally, disrupts nitric oxide signaling, impairing vasodilation promoting vasoconstriction, contributes complications. This review explores molecular mechanisms by pathogenesis disease T2DM. It also examines potential lifestyle modifications, such dietary changes physical activity, reducing mitigating risks this high-risk population. Understanding these critical for developing targeted therapeutic strategies improve outcomes

Language: Английский

Citations

7
Insulin resistance and cancer: molecular links and clinical perspectives DOI
Alfredo Caturano, Enes Erul,

Roberto Nilo

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Language: Английский

Citations

0
Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway DOI Creative Commons

Weipin Niu,

Xin Liu, Bo Deng

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 20, 2025

Increasing evidence highlights the critical role of Piezo1 in cardiovascular diseases, with its expression upregulated diabetic heart. However, involvement pathogenesis cardiomyopathy (DCM) remains unclear. This study aims to elucidate regulatory mitochondrial dynamics within context DCM and investigate underlying mechanisms. We constructed cardiac-specific knockout (Piezo1∆Myh6) mice. Type 1 diabetes was induced using streptozotocin (STZ) injection while type 2 established through a high-fat diet combined STZ. Echocardiography assessed left ventricular function, histological evaluations used HE Masson staining examine cardiac pathology Piezo1fl/fl controls, Piezo1∆Myh6 Mitochondrial function including oxygen species level, morphology, respiration rate were also assessed. Our findings revealed that myocardium mice high-glucose-treated cells. Cardiac-specific improved dysfunction ameliorated fibrosis Moreover, deficiency attenuated impairment. exhibited increased calpain activity excessive fission mediated by Drp1 obvious reduced fusion; however, restored levels dysfunction. These observations corroborated H9C2 cells neonatal mouse cardiomyocytes. phosphorylation ERK1/2 vivo vitro. or treatment inhibitor function. provides first is elevated modulation dynamics, which reversed deficiency. Thus, inhibition may provide promising therapeutic strategy for DCM. In cardiomyocytes mice, Ca2+ entry upregulates activity, phosphorylated level Drp1. Therefore, shown hearts. Whereas, cardiomyocyte-specific alleviates

Language: Английский

Citations

0
Global burden of Type 2 Diabetes Mellitus attributable to dietary risks in elderly adults: insights from the Global Burden of Disease study 2021 DOI Creative Commons
Yiting Tang, Yupeng Chen, Yang Zhou

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 24, 2025

Background Type 2 Diabetes Mellitus (T2DM) poses a significant global health challenge, particularly among elderly adults. Dietary risk factors, such as high consumption of processed meats and sugar-sweetened beverages low intake whole grains fruits, play critical role in the burden T2DM. This study aims to comprehensively quantify T2DM attributable dietary risks adults, identify factors driving disease burden, evaluate temporal, regional, demographic variations inform targeted public strategies interventions for reducing impact Methods utilized data from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021 assess adults aged 65 years older across 204 countries territories. Metrics included age-standardized mortality rates (ASMR) disability-adjusted life-year (ASDR). analyzed grains, vegetables, fiber, well meat, red beverages. Joinpoint regression decomposition analyses were performed examine temporal trends drivers changes by region, SDI level, sex, age. Results In 2021, accounted 23.61% T2DM-related deaths 24.85% DALYs ASMR showed slight decline globally (AAPC: −0.08), while ASDR exhibited upward trend +0.7) 1990 2021. High regions demonstrated decreasing but persistent due prolonged survival with complications. Conversely, middle rapid increases ASDR, driven transitions limited healthcare resources. Males consistently bore higher than females, pronounced disparities regions. Aging population growth primary increasing globally. Conclusion underscores substantial highlights regional disparities. Targeted interventions, personalized nutritional strategies, improved access are essential mitigate this burden. Future research should explore emerging precision nutrition on prevention management.

Language: Английский

Citations

0