Gangliosides and Cholesterol: Dual Regulators of Neuronal Membrane Framework in Autism Spectrum Disorder DOI Open Access
Borna Puljko,

Marija Štracak,

Svjetlana Kalanj Bognar

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1322 - 1322

Published: Feb. 4, 2025

Autism spectrum disorder (ASD) is a neurodevelopmental with heterogeneous clinical presentation. Diagnosing ASD complex, and the criteria for diagnosis, as well term ASD, have changed during last decades. Diagnosis made based on observation accomplishment of specific diagnostic criteria, while particular biomarker does not yet exist. However, studies universally report disequilibrium in membrane lipid content, pointing to unique neurolipid signature ASD. This review sheds light possible role cholesterol gangliosides, complex glycosphingolipids, development In addition maintaining integrity, neuronal signaling, synaptic plasticity, these lipids play neurotransmitter release calcium signaling. Evidence linking lipidome changes includes low levels, unusual ganglioside metabolic profiles. symptoms may be mitigated therapeutic interventions targeting composition membranes. restoring equilibrium central nervous system remains challenge. underscores need comprehensive research into metabolism uncover practical insights etiology treatment lipidomics emerges major area research.

Language: Английский

Gangliosides and Cholesterol: Dual Regulators of Neuronal Membrane Framework in Autism Spectrum Disorder DOI Open Access
Borna Puljko,

Marija Štracak,

Svjetlana Kalanj Bognar

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1322 - 1322

Published: Feb. 4, 2025

Autism spectrum disorder (ASD) is a neurodevelopmental with heterogeneous clinical presentation. Diagnosing ASD complex, and the criteria for diagnosis, as well term ASD, have changed during last decades. Diagnosis made based on observation accomplishment of specific diagnostic criteria, while particular biomarker does not yet exist. However, studies universally report disequilibrium in membrane lipid content, pointing to unique neurolipid signature ASD. This review sheds light possible role cholesterol gangliosides, complex glycosphingolipids, development In addition maintaining integrity, neuronal signaling, synaptic plasticity, these lipids play neurotransmitter release calcium signaling. Evidence linking lipidome changes includes low levels, unusual ganglioside metabolic profiles. symptoms may be mitigated therapeutic interventions targeting composition membranes. restoring equilibrium central nervous system remains challenge. underscores need comprehensive research into metabolism uncover practical insights etiology treatment lipidomics emerges major area research.

Language: Английский

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