The Role of Aryl Hydrocarbon Receptor in Skin Homeostasis: Implications for Therapeutic Strategies in Skin Disorders

Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(2)

Published: Jan. 27, 2025

ABSTRACT The aryl hydrocarbon receptor (AhR), a ligand‐activated transcription factor, is extensively expressed in diverse human organs and plays pivotal role mediating the onset, progression, severity of numerous diseases. Recent research has explored substantial impact AhR on skin homeostasis related pathologies. As multi‐layered organ, comprises multiple cell populations that express AhR. In this review, we introduce various cells its barrier function. Furthermore, explore involvement development diseases, highlighting potential as therapeutic target for disorders. By targeting AhR, may open new avenues novel efficient disease treatments.

Language: Английский

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Time-Series Data-Driven PM2.5 Forecasting: From Theoretical Framework to Empirical Analysis

Atmosphere, Journal Year: 2025, Volume and Issue: 16(3), P. 292 - 292

Published: Feb. 28, 2025

PM2.5 in air pollution poses a significant threat to public health and the ecological environment. There is an urgent need develop accurate prediction models support decision-making reduce risks. This review comprehensively explores progress of concentration prediction, covering bibliometric trends, time series data characteristics, deep learning applications, future development directions. article obtained on 2327 journal articles published from 2014 2024 WOS database. Bibliometric analysis shows that research output growing rapidly, with China United States playing leading role, recent increasingly focusing data-driven methods such as learning. Key sources include ground monitoring, meteorological observations, remote sensing, socioeconomic activity data. Deep (including CNN, RNN, LSTM, Transformer) perform well capturing complex temporal dependencies. With its self-attention mechanism parallel processing capabilities, Transformer particularly outstanding addressing challenges long sequence modeling. Despite these advances, integration, model interpretability, computational cost remain. Emerging technologies meta-learning, graph neural networks, multi-scale modeling offer promising solutions while integrating into real-world applications smart city systems can enhance practical impact. provides informative guide for researchers novices, providing understanding cutting-edge methods, systematic paths. It aims promote robust efficient contribute global management protection efforts.

Language: Английский

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Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102837 - 102837

Published: March 6, 2025

Language: Английский

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Amelioration of Particulate Matter-Induced Oxidative Stress by a Bioactive Hizikia fusiformis Extract: A Functional Biomaterial for Cosmeceutical Applications

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(3), P. 135 - 135

Published: March 20, 2025

Air pollution-related skin damage has heightened the demand for natural protective agents. Hizikia fusiformis, a brown seaweed rich in fucoidan and bioactive fatty acids (α-linolenic acid, eicosatetraenoic palmitic acid), possesses antioxidant anti-inflammatory properties. This study investigated effects of H. fusiformis ethanol extract (HFE) against particulate matter (PM)-induced oxidative stress, inflammation, apoptosis human keratinocytes. Antioxidant activity was assessed using DPPH hydroxyl radical scavenging assays, while PM-induced cytotoxicity, ROS generation, inflammatory markers, apoptotic pathways were evaluated WST-8 assay, DCFH2-DA, qPCR, western blotting, Hoechst staining. HFE significantly reduced levels, enhanced enzyme activity, mitigated cytotoxicity. These mediated by acids, which modulated (NF-κB MAPK), stabilized membranes, inhibited (Bcl-2, Bax, caspase-3). Collectively, these findings highlight HFE’s potential as anti-pollution skincare ingredient, supporting further vivo studies formulation development.

Language: Английский

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Particulate matter pollution alters the bacterial community structure on the human skin with enriching the Acinetobacter and Pseudomonas

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118061 - 118061

Published: March 22, 2025

Language: Английский

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Effects of Culture Medium-Based and Topical Anti-Pollution Treatments on PM-Induced Skin Damage Using a Human Ex Vivo Model

Cosmetics, Journal Year: 2025, Volume and Issue: 12(2), P. 64 - 64

Published: March 31, 2025

Particulate matter (PM) is a significant pollutant that induces oxidative stress, inflammation, and structural skin damage, contributing to premature aging reduced integrity. In this study, PM was applied topically human ex vivo tissues simulate real-world exposure, while test compounds were delivered using the culture medium mimic systemic absorption or for direct surface treatment. Culture medium-based treatments included indomethacin, L-ascorbic acid, rapamycin, whereas topical treatment involved retinol epigallocatechin gallate (EGCG). exposure increased hydrogen peroxide (H2O2), interleukin 6 (IL-6), matrix metalloproteinase 1 (MMP-1), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE-2), decreasing collagen type I hyaluronic acid (HYA). improved MMP-1 COX-2 expression, with rapamycin lowering PGE-2, indomethacin restoring HYA. uniquely IL-6. Topical treatments, including EGCG, effectively H2O2 restored I. While both agents exhibited antioxidant activity, further IL-6, emphasizing its anti-inflammatory role. These results highlight complementary protective effects of systemic-like in mitigating PM-induced damage. Future research should optimize protocols validate efficacy under conditions enhance protection polluted environments.

Language: Английский

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Natural products as promising therapeutics for fine particulate matter–induced skin damage: a review of pre-clinical studies on skin inflammation and barrier dysfunction

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19316 - e19316

Published: April 28, 2025

Particulate matter less than 2.5 µm (PM2.5) is a significant air pollutant and linked to an increased risk of health conditions, including skin diseases. The skin, as the first barrier largest organ, primarily damaged by PM2.5 through different pathways. Several studies have shown that upregulates inflammatory responses excessive production reactive oxygen species (ROS) several cytokines, leading PM2.5-induced damage. ROS/mitogen-activated protein kinase (MAPK) Cyclooxygenase-2-Prostaglandin E2 (COX2/PGE2) pathways are activated free radical scavenging phase II detoxification. Natural products been suggested therapeutic agents for mitigating We elaborate on mechanisms action natural their functions protectants against environmental This review highlights optimal doses clinical study, which may benefit dermatologists, molecular biologists, clinicians, healthcare professionals in preventive alternative medicine. available scientific literature published between 1999 2024 was searched using PubMed Google Scholar. Multiple keywords related topic were used. Only 41 screened articles chosen this review, they most relevant publications advantages specific targeting injury. All meeting criteria being original full written English included. summarized products, phenolic/polyphenolic compounds flavonoids, can act anti-inflammatory antioxidant protecting oxidative stress, inhibiting enzymes promote formation, enhancing enzyme activity, reducing overall ROS formation. demonstrated efficacy alleviating intracellular ROS, mitochondrial dysfunction, autophagy, apoptosis caused PM2.5. In addition, phytochemical support restoration wound healing process muscle contraction impaired pollutants, such UV rays. promising protect environment-mediated problems focusing action. Particular emphasis placed compounds, sulforaphane, hesperidin, quercetin, catechin, diphloroethohydroxycarmalol, resveratrol, ginsenoside, become interesting candidates nutraceuticals due potential reduce reliance conventional medicines. However, low stability bioavailability remain challenges use; therefore, further research development warranted.

Language: Английский

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Exploring the toxicological impact of bisphenol a exposure on psoriasis through network toxicology, machine learning, and multi-dimensional bioinformatics analysis

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 385, P. 125708 - 125708

Published: May 10, 2025

Language: Английский

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Current Situation and Prospect of Geospatial AI in Air Pollution Prediction

Atmosphere, Journal Year: 2024, Volume and Issue: 15(12), P. 1411 - 1411

Published: Nov. 24, 2024

Faced with increasingly serious environmental problems, scientists have conducted extensive research, among which the importance of air quality prediction is becoming prominent. This article briefly reviews utilization geographic artificial intelligence (AI) in pollution. Firstly, this paper conducts a literature metrology analysis on research geographical AI used That is, 607 documents are retrieved from Web Science (WOS) using appropriate keywords, and Citespace to summarize hotspots frontier countries field. Among them, China plays constructive role fields research. The data characteristics Earth science direction field were proposed. It then quickly expanded investigate In addition, based summarizing current status Artificial Neural Network (ANN), Recurrent (RNN), hybrid neural network models predicting (mainly PM2.5), also proposes areas for improvement. Finally, prospects future study aims development trends quality, as well methods, provide

Language: Английский

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Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 23 - 23

Published: Dec. 27, 2024

Particulate matter (PM), particularly fine (PM2.5) and ultrafine (PM0.1) particles, originates from both natural anthropogenic sources, such as biomass burning vehicle emissions. These particles contain harmful compounds that pose significant health risks. Upon inhalation, ingestion, or dermal contact, PM can penetrate biological systems, inducing oxidative stress, inflammation, DNA damage, which contribute to a range of complications. This review comprehensively examines the protective potential products against PM-induced issues across various physiological including respiratory, cardiovascular, skin, neurological, gastrointestinal, ocular systems. It provides valuable insights into risks associated with exposure highlights therapeutic promise herbal medicines by focusing on have demonstrated properties in vitro vivo PM2.5-induced models. Numerous phytochemicals shown efficacy mitigating cellular damage through their ability counteract suppress pro-inflammatory responses, enhance defense mechanisms. combined actions collectively protect tissues PM-related dysfunction. establishes foundation for future research development effective interventions combat issues. However, further studies, clinical trials, are essential evaluate safety, optimal dosages, long-term effectiveness treatments patients under chronic exposure.

Language: Английский

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