Amlodipine with letrozole as maintenance post chemotherapy –targeting calcium calcinuerin calmodulin pathway and aromatase inhibitor indisseminated Endometrioid adenocarcinoma of the endometrium a – A case report
Abstract
Background:
World
is
now
clinging
to
immune
checkpoint
inhibitor
in
almost
every
type
of
cancer.
PD-1
and
PD-L1
are
taking
over
the
treatment
algorithm.
But
cost
an
issue;
we
have
a
perspective
target
energy
mechanism
cytotoxic
T
cells
modulate
representation
receptor
so
as
increase
immunogenicity
cells.
Cellular
largely
dependent
on
calcium
channels
pharmacological
modulation
it
may
help
modulating
response
cytotoxicT
cell.
Clinical
case;
We
hereby
present
case
endometroid
adenocarcinoma
endometrium
successfully
treated
with
CCB
hormonal
after
short
course
chemotherapy.
(paclitaxel
80
mg/m2
weekly
carboplatin
AUC-2)
given
basis,
she
still
remission,
begin
was
stage
IV
ca
due
peritoneal
seeding
disease(
TNM&
FIGO)
,
but
gradually
her
reversed
back
1
(
TNM)
hysterectomy
disease
free
since
last
3
years.
Conclusion:
This
study
hints
at
possible
role
Calcium
channel
blockers
(CCB)
modulation,
which
plays
pivotal
cells.1Modulation
influx
can
modify
cell
activation
proliferation
1.Estrogen
critical
upregulation
related
proteins.
blockers(CCB)
likeamlodipine,
hence
be
considered
for
repurposingin
thetreatment
endometrial
cancer.2
Amlodipine
used
along
letrozole
especially
female
reproductive
tract
malignancies
like
concerned.
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: April 17, 2025
Language: Английский