Exploring the gut microbiome’s influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies DOI
Ayrton Bangolo, Behzad Amoozgar,

Maryam Habibi

et al.

World Journal of Gastrointestinal Pharmacology and Therapeutics, Journal Year: 2025, Volume and Issue: 16(2)

Published: June 3, 2025

BACKGROUND Anemia is a prevalent and challenging complication in patients with hematologic solid malignancies, which stems from the direct effects of malignancy, treatment-induced toxicities, systemic inflammation. It affects patients’ survival, functional status, quality life profoundly. Recent literature has highlighted emerging role gut microbiome pathogenesis cancer-associated anemia. The microbiota, through its intricate interplay iron metabolism, inflammatory pathways, immune modulation, may either exacerbate or ameliorate anemia depending on composition, integrity. Dysbiosis, characterized by disruption microbial ecosystem, very common cancer patients. This imbalance implicated causation diminished absorption, persistent low-grade inflammation, suppression erythropoiesis. AIM To consolidate current evidence regarding between setting malignancies. aims to provide detailed exploration mechanistic links dysbiosis anemia, identifies unique challenges associated various types, evaluates efficacy microbiome-focused therapies. Through this integrative approach, review seeks establish foundation for innovative clinical strategies aimed at mitigating improving patient outcomes oncology. METHODS A search was performed using multiple databases, including Google Scholar, PubMed, Scopus, Web Science, combination keywords Boolean operators refine results. Keywords included “cancer-associated anemia”, “gut microbiome”, “intestinal microbiota”, “iron metabolism”, dysbiosis”, “short-chain fatty acids”, “hematopoiesis”, “probiotics”, “prebiotics”, “fecal microbiota transplantation”. Articles published English 2000 December 2024 were included, focus contemporary relevant findings. RESULTS Therapeutic restoration homeostasis, such as probiotics, prebiotics, dietary interventions, fecal transplantation (FMT), can inhibit anemia-causing pathways enhancing diversity, suppressing detrimental flora, reducing inflammation optimizing nutrient absorption. CONCLUSION Gut causes impairs response chemotherapy Microbiome-centered modifications, FMT, have shown restoring balance, bioavailability. Emerging approaches, engineered probiotics bacteriophage therapies, are promising precision-based, customizable solutions compositions imbalances. Future research should integrating microbiome-targeted established

Language: Английский

Emerging insights into the gut microbiota as a key regulator of immunity and response to immunotherapy in hepatocellular carcinoma DOI Creative Commons
Siqi Ren, Yinping Zhang,

Xingyue Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 25, 2025

The gut microbiota, a complex microbial ecosystem closely connected to the liver via portal vein, has emerged as critical regulator of health and disease. Numerous studies have underscored its role in onset progression disorders, including alcoholic disease, metabolic dysfunction-associated steatotic disease (MASLD), steatohepatitis (MASH), fibrosis, cirrhosis, hepatocellular carcinoma (HCC). This review provides comprehensive overview current insights into influence microbiota on HCC progression, particularly effects immune cells within tumor microenvironment (TME). Furthermore, we explore potential microbiota-targeted interventions, such antibiotics, probiotics, prebiotics, fecal transplantation (FMT), modulate response improve outcomes immunotherapy HCC. By synthesizing from recent studies, this aims highlight microbiota-based strategies that may enhance outcomes, advancing personalized approaches treatment.

Language: Английский

Citations

1
Targeting breast cancer: the promise of phage-based nanomedicines DOI

Sarah Gholami,

Hossein Saffarfar,

Mohammad Reza Mehraban

et al.

Breast Cancer Research and Treatment, Journal Year: 2025, Volume and Issue: 211(3), P. 561 - 580

Published: April 17, 2025

Language: Английский

Citations

0
Advances in the Functionalization of Vaccine Delivery Systems: Innovative Strategies and Translational Perspectives DOI Creative Commons
Ingrid Andrêssa de Moura, Anna Jéssica Duarte Silva, Larissa Silva de Macêdo

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 640 - 640

Published: May 12, 2025

The development of effective vaccines requires a rational design that considers the interaction between antigens, their vectors, and immune system in addition to activation pathways induce safe specific response. efficacy vaccine formulation depends on nature antigen, protection offered by delivery system, ability potentiate response, precise release immunogen. Carrier systems such as lipid nanoparticles, polymers, exosomes, microorganisms can be functionalized chemical, physical, or biological methods generate selective improved biodistribution profiles. These enhance with target cells, thereby improving immunological efficacy. conjugation ligands modification parameters shape, charge, size vectors specificity, stability, efficiency antigen transport cellular compartments, facilitating robust This study examines modifications systems, focusing biomolecules physicochemical changes presentation. Additionally, we examine innovative methods, including microneedles, electroporation, needle-free show potential for enhancing

Language: Английский

Citations

0
Exploring the gut microbiome’s influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies DOI
Ayrton Bangolo, Behzad Amoozgar,

Maryam Habibi

et al.

World Journal of Gastrointestinal Pharmacology and Therapeutics, Journal Year: 2025, Volume and Issue: 16(2)

Published: June 3, 2025

BACKGROUND Anemia is a prevalent and challenging complication in patients with hematologic solid malignancies, which stems from the direct effects of malignancy, treatment-induced toxicities, systemic inflammation. It affects patients’ survival, functional status, quality life profoundly. Recent literature has highlighted emerging role gut microbiome pathogenesis cancer-associated anemia. The microbiota, through its intricate interplay iron metabolism, inflammatory pathways, immune modulation, may either exacerbate or ameliorate anemia depending on composition, integrity. Dysbiosis, characterized by disruption microbial ecosystem, very common cancer patients. This imbalance implicated causation diminished absorption, persistent low-grade inflammation, suppression erythropoiesis. AIM To consolidate current evidence regarding between setting malignancies. aims to provide detailed exploration mechanistic links dysbiosis anemia, identifies unique challenges associated various types, evaluates efficacy microbiome-focused therapies. Through this integrative approach, review seeks establish foundation for innovative clinical strategies aimed at mitigating improving patient outcomes oncology. METHODS A search was performed using multiple databases, including Google Scholar, PubMed, Scopus, Web Science, combination keywords Boolean operators refine results. Keywords included “cancer-associated anemia”, “gut microbiome”, “intestinal microbiota”, “iron metabolism”, dysbiosis”, “short-chain fatty acids”, “hematopoiesis”, “probiotics”, “prebiotics”, “fecal microbiota transplantation”. Articles published English 2000 December 2024 were included, focus contemporary relevant findings. RESULTS Therapeutic restoration homeostasis, such as probiotics, prebiotics, dietary interventions, fecal transplantation (FMT), can inhibit anemia-causing pathways enhancing diversity, suppressing detrimental flora, reducing inflammation optimizing nutrient absorption. CONCLUSION Gut causes impairs response chemotherapy Microbiome-centered modifications, FMT, have shown restoring balance, bioavailability. Emerging approaches, engineered probiotics bacteriophage therapies, are promising precision-based, customizable solutions compositions imbalances. Future research should integrating microbiome-targeted established

Language: Английский

Citations

0