Decoding metabolic connections: the role of salivary amylase activity in modulating visceral fat and triglyceride glucose index DOI Creative Commons
Gita Erta, Gita Gersone,

Antra Jurka

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 18, 2025

Salivary amylase activity (SAA) is recognized as a potential biomarker for metabolic health. Previous studies suggest an association between SAA and insulin sensitivity, but the mechanisms remain unclear. This study investigates relationship SAA, visceral fat (VF), triglyceride-glucose (TyG) index to clarify pathways linking risk factors. cross-sectional analysed data from women of reproductive age who were classified overweight. Linear regression models used assess associations salivary (SAA), (VF) index, while adjusting confounding variables such age, body mass (BMI), physical dietary patterns. Mediation analysis was conducted determine whether VF mediates TyG index. Higher inversely associated with (β = -0.45, 95% CI: -0.65 -0.25, p < 0.001). No direct observed -0.10, -0.25 0.05, 0.18) after adjustment covariates. revealed that significantly mediated The indirect effect on through (A × B) statistically significant -0.16, -0.26 -0.08), accounting 45% total effect. These findings higher may confer benefits by reducing VF, thereby indirectly influencing highlights critical role in mediating protective effects health provides insights into intervention.

Language: Английский

Decoding metabolic connections: the role of salivary amylase activity in modulating visceral fat and triglyceride glucose index DOI Creative Commons
Gita Erta, Gita Gersone,

Antra Jurka

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 18, 2025

Salivary amylase activity (SAA) is recognized as a potential biomarker for metabolic health. Previous studies suggest an association between SAA and insulin sensitivity, but the mechanisms remain unclear. This study investigates relationship SAA, visceral fat (VF), triglyceride-glucose (TyG) index to clarify pathways linking risk factors. cross-sectional analysed data from women of reproductive age who were classified overweight. Linear regression models used assess associations salivary (SAA), (VF) index, while adjusting confounding variables such age, body mass (BMI), physical dietary patterns. Mediation analysis was conducted determine whether VF mediates TyG index. Higher inversely associated with (β = -0.45, 95% CI: -0.65 -0.25, p < 0.001). No direct observed -0.10, -0.25 0.05, 0.18) after adjustment covariates. revealed that significantly mediated The indirect effect on through (A × B) statistically significant -0.16, -0.26 -0.08), accounting 45% total effect. These findings higher may confer benefits by reducing VF, thereby indirectly influencing highlights critical role in mediating protective effects health provides insights into intervention.

Language: Английский

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