Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer Risk

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 135 - 135

Published: Jan. 21, 2025

Background: Cervical cancer (CC) is the fourth most common diagnosis in women worldwide. Infection with high-risk human papillomavirus (HPV) a critical but not determinative condition for CC development, as several co-factors modulate progression of HPV-associated cervical lesions. Interleukin-8 (IL-8) and Interleukin-16 (IL-16) are chemokine-like interleukins involved pathogenesis various cancers. Singular studies Asian populations have suggested potential role IL-8 rs4073 (−251 A>T) IL-16 rs1131445 (3′UTR T>C) carcinogenesis. Methods: A case-control study was conducted European cohort 339 women, including 126 patients 213 controls. Four SNPs, A>T), rs2227306 (+781 C>T), rs1126647 (+2767 rs2227543 (+1633 four polymorphism, rs4778889 (−295 T>C), rs11556218 (3441 T>G), rs4072111 (1300 were assessed using RFLP-PCR analyzed under seven inheritance models. Subgroup analyses stratified by menopausal status (age threshold 51 years), disease stage, histological subtype. Results: significantly associated an increased risk premenopausal co-dominant (p = 0.038), dominant 0.022), heterozygote 0.045) models, identifying T allele (OR 2.31, CI95% 1.17–4.56; p 0.017). In aged over 51, 0.048) overdominant 0.042) models model 0.092). None SNPs entire cohort. Specifically, neither nor rs4073, previously reported factors populations, this Conclusions: These findings highlight age stage immunity susceptibility, suggest that may function differently carcinogenesis compared other cancers, emphasize importance ethnic background risk, warranting further research.

Language: Английский

Prof. Dr. Giovanni De Toni—Editorial for the Commemoration of a Pediatric Luminary

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3198 - 3198

Published: March 30, 2025

Living in Liguria, acknowledging that the sea may be a metaphor for human condition is not difficult [...]

Language: Английский