PLATELET-RICH PLASMA ENHANCES THE ANTI-INFLAMMATORY EFFECT OF ELLAGIC ACID IN CARRAGEENAN-INDUCED EXUDATIVE INFLAMMATION DOI Creative Commons
R. S. Vastyanov, O. M. Stoyanov, Nataliya A. Zolotarova

et al.

Medical Science of Ukraine (MSU), Journal Year: 2024, Volume and Issue: 20(4), P. 56 - 66

Published: Dec. 30, 2024

Background. Inflammation is an evolutionary developed general biological protective and adaptive reaction of the body in response to alterative agents allergic, toxic genesis influence. Modern treatment inflammation requires prolonged administration anti-inflammatory both steroid non-steroidal pharmacological which increase risk expressive adverse reactions complications development. We were interested effects plant polyphenols, especially ellagic acid, autologous platelet-rich plasma investigation. Aim. To determine expression effect conditions its complex use a model carrageenan-induced exudative rats paw. Materials methods. In work, paw edema was induced acute experiment. Platelet-rich acids separate combined used with therapeutic purposes animals. Diclofenac sodium chosen as reference drug. The aseptic exidative - volume thickness inflammatory edema, well severity somatosensory (pain) sensitivity tail-flick “hot plate” tests determined 30 min, 1, 2, 4 6 hrs after carrageenan Results. data obtained indicate achieved possibility efficacy increasing by adding regimen. This characterized rats’ reduction, index decreases restoration animals acid administration. investigated compounds maximal at delayed stages reaction, namely, starting from hour continued till end trial. Conclusion. carrageenan-initiated suppressed result due this scheme impact on main chains revealed together pathogenetic background rat prove reasonability clinical testing.

Language: Английский

Kynurenine Pathway in Epilepsy: Unraveling Its Role in Glutamate Excitotoxicity, GABAergic Dysregulation, Neuroinflammation, and Mitochondrial Dysfunction DOI
Manpreet Kaur,

Pratyush Porel,

Ronak Y. Patel

et al.

Neurotoxicity Research, Journal Year: 2025, Volume and Issue: 43(2)

Published: March 28, 2025

Language: Английский

Citations

0
Pharmacological potential of calorie restriction mimetics in mitigating brain aging DOI

Varsha Pai,

Ishika Singh,

Abhishek Kumar Singh

et al.

Advances in pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Pathological and Inflammatory Consequences of Aging DOI Creative Commons
Mario García‐Domínguez

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 404 - 404

Published: March 12, 2025

Aging is a complex, progressive, and irreversible biological process that entails numerous structural functional changes in the organism. These affect all bodily systems, reducing their ability to respond adapt environment. Chronic inflammation one of key factors driving development age-related diseases, ultimately causing substantial decline abilities older individuals. This persistent inflammatory state (commonly known as “inflammaging”) characterized by elevated levels pro-inflammatory cytokines, an increase oxidative stress, perturbation immune homeostasis. Several factors, including cellular senescence, contribute this milieu, thereby amplifying conditions such cardiovascular disease, neurodegeneration, metabolic disorders. Exploring mechanisms chronic aging essential for developing targeted interventions aimed at promoting healthy aging. review explains strong connection between inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, lifestyle changes.

Language: Английский

Citations

0
Editorial: Similarities and differences between cellular and molecular mechanisms of normal brain aging and neurodegeneration DOI Creative Commons
Anamaria Jurcău

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 16, 2025

Language: Английский

Citations

0
Role of IL-16 in age-related skeletal muscle atrophy: an integrated study DOI Creative Commons
Wenliang Fan,

Zhibang Zhao,

Liqiang Wang

et al.

BMC Musculoskeletal Disorders, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 17, 2025

In this study, we aim to explore the roles of IL-16 in sarcopenia based on older orthopedic patients and animal research. This clinical research study was an observational investigation included all with trauma admitted our department between January 2021 2022. Patients were identified if they have both low hand grip strength (HGS) appendicular skeletal muscle mass (ASM). Propensity score matching (PSM) performed reduce bias caused by co-factors levels normal compared. research, mice treated identify effects function mass. Then models established anti-IL-16 potential therapeutical effect targeting IL-16. 421 individuals 77 as sarcopenia. matched populations, serum HGS, ASM, significantly higher than (all p < 0.001). The showed impaired physical performance loss Using antibodies may rescue traits botulinum toxin type A. Individuals high a risk impairs leads atrophy mice, these could be reduced

Language: Английский

Citations

0
The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies DOI Creative Commons
Vharoon Sharma Nunkoo,

Alexander Cristian,

Anamaria Jurcău

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2540 - 2540

Published: Nov. 7, 2024

The impressive achievements made in the last century extending lifespan have led to a significant growth rate of elderly individuals populations across world and an exponential increase incidence age-related conditions such as cardiovascular diseases, diabetes mellitus type 2, neurodegenerative diseases. To date, geroscientists identified 12 hallmarks aging (genomic instability, telomere attrition, epigenetic alterations, loss proteostasis, impaired macroautophagy, mitochondrial dysfunction, nutrient sensing, cellular senescence, stem cell exhaustion, defective intercellular communication, chronic inflammation, gut dysbiosis), intricately linked among each other, which can be targeted with senolytic or senomorphic drugs, well more aggressive approaches cell-based therapies. side effects seriously limit use these drugs. However, since rejuvenation is dream mankind, future research expected improve tolerability available drugs highlight novel strategies. In meantime, medical community, healthcare providers, society should decide when start treatments how tailor them individually.

Language: Английский

Citations

3
Oxidative Stress in the Pathogenesis of Neurodegenerative Diseases DOI Creative Commons
Maria Carolina Jurcău, Anamaria Jurcău,

Radu Diaconu

et al.

Stresses, Journal Year: 2024, Volume and Issue: 4(4), P. 827 - 849

Published: Dec. 2, 2024

Neurodegenerative diseases are devastating conditions with a rising incidence and prevalence due to the aging of population for which we currently do not have efficient therapies. Despite compelling evidence provided by basic research on involvement oxidative stress in their pathogenesis, most trials antioxidants failed. The reasons may relate low bioavailability used compounds or starting therapy late, when pathogenic cascades already induced irreversible damage. current review discusses sources central nervous system, reactive oxygen species pathogenesis Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, importance further improved delivery methods as well search biomarkers that could help early diagnosis hope finding more therapies these diseases.

Language: Английский

Citations

1
PLATELET-RICH PLASMA ENHANCES THE ANTI-INFLAMMATORY EFFECT OF ELLAGIC ACID IN CARRAGEENAN-INDUCED EXUDATIVE INFLAMMATION DOI Creative Commons
R. S. Vastyanov, O. M. Stoyanov, Nataliya A. Zolotarova

et al.

Medical Science of Ukraine (MSU), Journal Year: 2024, Volume and Issue: 20(4), P. 56 - 66

Published: Dec. 30, 2024

Background. Inflammation is an evolutionary developed general biological protective and adaptive reaction of the body in response to alterative agents allergic, toxic genesis influence. Modern treatment inflammation requires prolonged administration anti-inflammatory both steroid non-steroidal pharmacological which increase risk expressive adverse reactions complications development. We were interested effects plant polyphenols, especially ellagic acid, autologous platelet-rich plasma investigation. Aim. To determine expression effect conditions its complex use a model carrageenan-induced exudative rats paw. Materials methods. In work, paw edema was induced acute experiment. Platelet-rich acids separate combined used with therapeutic purposes animals. Diclofenac sodium chosen as reference drug. The aseptic exidative - volume thickness inflammatory edema, well severity somatosensory (pain) sensitivity tail-flick “hot plate” tests determined 30 min, 1, 2, 4 6 hrs after carrageenan Results. data obtained indicate achieved possibility efficacy increasing by adding regimen. This characterized rats’ reduction, index decreases restoration animals acid administration. investigated compounds maximal at delayed stages reaction, namely, starting from hour continued till end trial. Conclusion. carrageenan-initiated suppressed result due this scheme impact on main chains revealed together pathogenetic background rat prove reasonability clinical testing.

Language: Английский

Citations

0