Neodymium doped graphene quantum dots/PANI composite for supercapacitor application

Journal of Alloys and Compounds, Journal Year: 2025, Volume and Issue: 1012, P. 178516 - 178516

Published: Jan. 1, 2025

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Current Research in Drug-Free Cancer Therapies

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 341 - 341

Published: March 26, 2025

Cancer treatment has historically depended on conventional methods like chemotherapy, radiation, and surgery; however, these strategies frequently present considerable limitations, including toxicity, resistance, negative impacts healthy tissues. In addressing challenges, drug-free cancer therapies have developed as viable alternatives, utilizing advanced physical biological to specifically target tumor cells while reducing damage normal This review examines several strategies, such high-intensity focused energy beams, nanosecond pulsed electric fields, photothermal therapy well the use of inorganic nanoparticles promote selective apoptosis. We also investigate significance targeting microenvironment, precision medicine, immunotherapy in progression personalized therapies. Although approaches demonstrate significant promise, challenges scalability, safety, regulatory obstacles must be resolved for clinical application. paper presents an overview current research therapies, emphasizing recent advancements, underlying scientific principles, steps required implementation.

Language: Английский

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Graphene Quantum Dot‐Based SEPSIS Immunosensor Using Procalcitonin as a Biomarker

Electroanalysis, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 1, 2025

This study presents a targeted impedimetric immunosensor for the detection of procalcitonin (PCT), biomarker associated with SEPSIS. The was operated based on interaction between PCT antibody (anti‐PCT) and antigen, utilizing graphene quantum dot (GQD)‐modified carbon screen‐printed electrode (SPCE). Herein, GQDs, known their large surface area excellent electrical conductivity, served as matrix immobilizing anti‐PCT, thereby enhancing electrochemical signal. Following immobilization anti‐PCT onto GQD@SPCE, antigen monitored by using impedance spectroscopy. Experimental parameters were optimized, analytical characteristics extensively evaluated. developed demonstrated linear range 0.1–10 ng/mL PCT, limit 0.01 quantification 0.03 ng/mL. Finally, GQD‐based applied to low‐ high‐level original control serum samples selected kit very promising recovery values obtained.

Language: Английский

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Peptide conjugated nintedanib loaded graphene quantum dots: characterization and cell based studies

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136298 - 136298

Published: Jan. 1, 2025

Language: Английский

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Carbon dots derived from Zingiber officinale Rosc (ginger) with hemostatic effects

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: March 4, 2025

Introduction Ginger, as a traditional Chinese medicine (TCM), can be used in clinical practice to treat various diseases. The product of ginger processed at high temperatures is called carbonized (CG), which has hemostatic effect that originally did not have. purpose this study investigate the CG and substances exert effects. Methods was prepared successfully obtained carbon dots (CG-CDs) from its aqueous solution. After fully characterizing structural information, evaluated using mouse tail bleeding liver injury models, clotting time capillary coagulation experiments. In addition, mechanism CG-CDs explored. Results average particle size observed 4.07 nm lattice spacing 0.216 nm. It mainly composed graphite structured carbon, with main constituent elements being C, N, O, containing functional groups such C=N, C=O, C-OH. FL spectrum showed maximum excitation wavelength 360 nm, emission 470 QY calculated 0.45%. shortened time, reduced volume, also for blood clotting. With increase CG-CDs, values FIB gradually increased, PT decreased. increased PLT count, activating factor TXB2, decreased 6-keto-PGF 1 α , PAI-1, t-PA. Conclusion activity, by exogenous co-coagulation pathways, increasing reducing t-PA, thereby affecting fibrinolytic system other pathways

Language: Английский

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The Role of Inorganic Nanomaterials in Overcoming Challenges in Colorectal Cancer Diagnosis and Therapy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 409 - 409

Published: March 25, 2025

Colorectal cancer poses a significant threat to human health due its high aggressiveness and poor prognosis. Key factors impacting patient outcomes include post-surgical recurrence, chemotherapeutic drug resistance, insensitivity immunotherapy. Consequently, early diagnosis the development of effective targeted therapies are essential for improving prevention treatment strategies. Inorganic nanomaterials have gained prominence in colorectal owing their unique size, advantageous properties, modifiability. Various types inorganic nanomaterials—such as metal-based, metal oxide, quantum dots, magnetic nanoparticles, carbon-based, rare-earth nanomaterials—have demonstrated potential enhancing multimodal imaging, delivery, synergistic therapies. These advancements underscore critical role therapeutic outcomes. This review highlights properties nanomaterials, summarizes recent applications progress treatment, discusses challenges translating these materials into clinical use. It aims provide valuable insights future research application management.

Language: Английский

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Advancing gut microbiome insights: Graphene quantum dot nanobiosensors for microbial metabolite detection

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162954 - 162954

Published: April 1, 2025

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Carbon Dot-Based Nanoparticles: A Promising Therapeutic Approach for Glioblastoma

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 7061 - 7092

Published: May 1, 2025

Glioblastoma (GBM) is a malignant tumor that currently still faces challenges for complete cure. Although GBM treatment has made great progress, the prognosis of patients poor due to interference various factors in such as blood-brain barrier (BBB), grade malignancy, intra- and intertumor heterogeneity, drug resistance, targeting anti-tumor drugs. In recent years, with marked advances nanotechnology, different types nanodrug delivery systems have been developed considered promising therapeutic measure gradually overcome chemotherapy resistance improve targeting. Carbon dots (CDs), new type NP, become research hotspot concern many researchers years. NPs based on CDs high modifiability functionalization, allowing covalent binding drugs, genes, immune cells photosensitizers, effectively reducing peripheral cytotoxicity. However, at present, are basic stage or preclinical exploratory stage, not yet entered clinical trial implementation application stage. Here, we review fundamental principles broader field their development history, classification, synthesis, potential treatment. Especially cancer, can only participate photodynamic therapy, photothermal sonodynamic chemodynamic chemotherapy, but also multi-modal combination therapy. hope provide some insights further research.

Language: Английский

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The Cooper-Pair Distribution Function of Untwisted-Misaligned Bilayer Graphene

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12549 - 12549

Published: Nov. 22, 2024

The Cooper-pair distribution function Dcp(ω,Tc) of Untwisted-Misaligned Bilayer Graphene (UMBLG) in the presence an external electric field is calculated and analysed within framework first-principle calculations. A bilayer graphene structure proposed using a structural geometric approximation, enabling simulation rotated at small angle, avoiding supercell calculation. UMBLG indicates superconducting state for specific configurations, which consistent with superconductivity Twisted (TBLG) reported literature. suggests that Cooper-pairs are possible low-frequency vibration region. Furthermore, approximation allowed evaluation effect on its critical temperature through Ncp parameter.

Language: Английский

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