Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 383 - 383
Published: Jan. 17, 2025
Trifolirhizin is an important flavonoid glycoside reported from the roots of medicinal plants such as Astragalus membranaceus, Sophora tonkinensis, Ononis vaginalis, Euchresta formosana, Subprostrate, spinose, and flavescens. It considered one constituents responsible for various properties these plants. Studies have revealed multiple pharmacological trifolirhizin: anti-inflammatory, antioxidant, antibacterial, anti-ulcerative colitis, antiasthma, hepatoprotective, osteogenic, skin-whitening, wound-healing, anticancer (against types cancers). Mechanistic studies trifolirhizin showed that it could act on target genes pathways NF-κB-MAPK, EGFR-MAPK, AMPK/mTOR, PI3K/Akt signaling pathways. These are also implicated in other diseases, suggesting potential therapeutic applications. Initial pharmacokinetic support candidature provide initial track may be pursued its development. Still, a compilation activities missing literature. This review uniquely compiles mechanistic insights trifolirhizin, addressing critical gaps development proposing strategies future research.
Language: Английский