Synergistic Antimicrobial Activity of Essential Oils and Vitamin C: Mechanisms, Molecular Targets and Therapeutic Potential DOI Creative Commons
Sylvia Stamova, Neli Ermenlieva, Gabriela Tsankova

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4294 - 4294

Published: April 13, 2025

Antimicrobial resistance (AMR) poses an increasing challenge to modern medicine, necessitating the search for novel therapeutic strategies. This study evaluates synergistic antimicrobial activity of oregano essential oil (OEO) and thyme (TEO) in combination with vitamin C against clinically relevant pathogens. The was assessed using MIC, MBC MFC assays, alongside silico analyses utilizing Swiss Target Prediction, STRING Reactome identify potential molecular targets underlying biological mechanisms. results demonstrate that significantly reduces MIC values E. coli C. albicans, indicating a effect, while antagonistic interaction observed S. aureus. Protein analysis revealed thymol carvacrol inhibit NF-κB activate Nrf2, leading modulation inflammatory antioxidant responses. Additionally, suppresses biofilm formation, enhances phagocytosis production reactive oxygen species (ROS). These findings suggest combining oils may serve as effective adjuvant approach therapy, particularly infections associated oxidative stress chronic inflammation.

Language: Английский

Special Issue “Antifungal Drug Discovery: Progresses, Challenges, Opportunities” DOI Open Access
Bernhard Biersack

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2065 - 2065

Published: Feb. 27, 2025

The considerable health risks associated with fungal infections are continuously rising, thereby requiring proper and efficient antifungal treatment options [...].

Language: Английский

Citations

0
New biological strategies for preventing and controlling food contaminants in the supply chain: Smart use of common plant-derived substances DOI
Changwei Liu, Lu Liu, Haiyan Lin

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 479, P. 143757 - 143757

Published: March 8, 2025

Language: Английский

Citations

0
Synergistic Antimicrobial Activity of Essential Oils and Vitamin C: Mechanisms, Molecular Targets and Therapeutic Potential DOI Creative Commons
Sylvia Stamova, Neli Ermenlieva, Gabriela Tsankova

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4294 - 4294

Published: April 13, 2025

Antimicrobial resistance (AMR) poses an increasing challenge to modern medicine, necessitating the search for novel therapeutic strategies. This study evaluates synergistic antimicrobial activity of oregano essential oil (OEO) and thyme (TEO) in combination with vitamin C against clinically relevant pathogens. The was assessed using MIC, MBC MFC assays, alongside silico analyses utilizing Swiss Target Prediction, STRING Reactome identify potential molecular targets underlying biological mechanisms. results demonstrate that significantly reduces MIC values E. coli C. albicans, indicating a effect, while antagonistic interaction observed S. aureus. Protein analysis revealed thymol carvacrol inhibit NF-κB activate Nrf2, leading modulation inflammatory antioxidant responses. Additionally, suppresses biofilm formation, enhances phagocytosis production reactive oxygen species (ROS). These findings suggest combining oils may serve as effective adjuvant approach therapy, particularly infections associated oxidative stress chronic inflammation.

Language: Английский

Citations

0