Genes, Journal Year: 2024, Volume and Issue: 15(12), P. 1509 - 1509
Published: Nov. 25, 2024
Cardiovascular disease (CVD) and Alzheimer's (AD) are two diseases highly prevalent in the aging population often co-occur. The exact relationship between is uncertain, though epidemiological studies have demonstrated that CVDs appear to increase risk of AD vice versa. This scoping review aims examine current identified overlapping genetics at individual gene level shared pathway level. Following PRISMA-ScR guidelines for a review, we searched PubMed Scopus databases from 1990 October 2024 articles involved (1) CVDs, (2) AD, (3) used statistical methods parse genetic relationships. Our search yielded 2918 articles, which 274 passed screening were organized into main sections: evidence risk; mechanisms. genes Highly penetrant familial simultaneously AD. However, most cases, sets dysregulated within larger-scale mechanisms, like changes lipid metabolism, blood pressure regulation, BBB breakdown, both contribute progression.
Language: Английский