Depletion of Cell Adhesion Molecule L1 from Microglia and Macrophages Reduces Recovery After Spinal Cord Injury DOI Open Access
Thomas Theis, Suneel Kumar,

Pratiksha Shah

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3285 - 3285

Published: April 1, 2025

The young mammalian central nervous system regenerates after spinal cord injury and recovers locomotion, whereas adult mice only show limited recovery that depends on the severity, genetic background, physical therapy. At molecular level, key regulators contribute to are cell adhesion molecules, such as L1CAM (L1). surface, L1 functions a homotypic receptor signal-transduces crucial in neuronal migration survival, neurite outgrowth, myelination, formation of synapses, synaptic plasticity. In system, is expressed by neurons. We now unexpectedly also 26% microglia, freshly isolated from 7-day-old mouse brain. postnatal day 21, 3% microglia L1-positive. Using mutant which deleted specifically monocytes 10- 14-week-old mice, functional was reduced up 4 weeks at lower thoracic levels. Also, NF200-immunoreactive 5-HT-immunoreactive fibers were found decreased below site compared wild-type mice. conclusion, microglial cells express stimulate outgrowth vitro, improve increase fiber densities caudal lesion site.

Language: Английский

Depletion of Cell Adhesion Molecule L1 from Microglia and Macrophages Reduces Recovery After Spinal Cord Injury DOI Open Access
Thomas Theis, Suneel Kumar,

Pratiksha Shah

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3285 - 3285

Published: April 1, 2025

The young mammalian central nervous system regenerates after spinal cord injury and recovers locomotion, whereas adult mice only show limited recovery that depends on the severity, genetic background, physical therapy. At molecular level, key regulators contribute to are cell adhesion molecules, such as L1CAM (L1). surface, L1 functions a homotypic receptor signal-transduces crucial in neuronal migration survival, neurite outgrowth, myelination, formation of synapses, synaptic plasticity. In system, is expressed by neurons. We now unexpectedly also 26% microglia, freshly isolated from 7-day-old mouse brain. postnatal day 21, 3% microglia L1-positive. Using mutant which deleted specifically monocytes 10- 14-week-old mice, functional was reduced up 4 weeks at lower thoracic levels. Also, NF200-immunoreactive 5-HT-immunoreactive fibers were found decreased below site compared wild-type mice. conclusion, microglial cells express stimulate outgrowth vitro, improve increase fiber densities caudal lesion site.

Language: Английский

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